Results 211 to 220 of about 122,182 (249)
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Lipid Metabolism and Tumor Antigen Presentation
2021Tumors always evade immune surveillance and block T cell activation in a poorly immunogenic and immunosuppressive environment. Cancer cells and immune cells exhibit metabolic reprogramming in the tumor microenvironment (TME), which intimately links immune cell function and edits tumor immunology.
Hong, Qin, Yaxi, Chen
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Presentation of lipid antigens to T cells
Immunology Letters, 2008T cells specific for lipid antigens participate in regulation of the immune response during infections, tumor immunosurveillance, allergy and autoimmune diseases. T cells recognize lipid antigens as complexes formed with CD1 antigen-presenting molecules, thus resembling recognition of MHC-peptide complexes.
Lucia Mori, Gennaro De Libero
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The Journal of Immunology, 1979
Abstract Dodecanoic acid side chains were coupled to the antigen 2,4-dinitrophenyl-bovine serum albumin (DNP-BSA) to make DNP-BSA-lipid. T cells from guinea pigs primed with DNP-BSA-lipid proliferate in vitro when stimulated by most, but not all, DNP-carrier conjugates.
C A Janeway +4 more
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Abstract Dodecanoic acid side chains were coupled to the antigen 2,4-dinitrophenyl-bovine serum albumin (DNP-BSA) to make DNP-BSA-lipid. T cells from guinea pigs primed with DNP-BSA-lipid proliferate in vitro when stimulated by most, but not all, DNP-carrier conjugates.
C A Janeway +4 more
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The CD1 family of lipid antigen-presenting molecules
Trends in Immunology, 1998Abstract The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting
Masahiko Sugita +2 more
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Novel insights into lipid antigen presentation
Trends in Immunology, 2012T cells recognizing lipid antigens are present in large numbers in circulating blood. They exert multiple functions including immunoregulation, tumour surveillance and protection during infection. Here, we review the latest information on the mechanisms of lipid antigen presentation by CD1 molecules.
De Libero, G., Mori, L.
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How T lymphocytes recognize lipid antigens
FEBS Letters, 2006 Recognition of lipid antigens by T lymphocytes is well established. Lipids are recognized by T cells when presented in association with CD1 antigen‐presenting molecules. Both microbial and self lipids stimulate specific T lymphocytes, thus participating in immune reactions during infections and autoimmune diseases.
Lucia Mori, Gennaro De Libero
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Recognition of lipid antigens by T cells
Nature Reviews Immunology, 2005Recent studies have shown that the recognition of lipid antigens by the immune system is important for defence against infection and other diseases, and that lipid-specific responses occur at higher frequencies than previously suspected. Thanks to several recent advances in this field, we now have a better appreciation of the molecular and cellular ...
De Libero G, Mori L
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Anatomy of CD1–lipid antigen complexes
Nature Reviews Immunology, 2005CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A', C', F' and T') and two antigen portals (C' and F').
D Branch, Moody +2 more
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Structure and Biology of Self Lipid Antigens
2007Self lipid antigens induce selection and expansion of autoreactive T cells which have a role in immunoregulation and disease pathogenesis. Here we review the important biological rules which determine lipid immunogenicity. The impact of lipid structure, synthesis, traffic, membrane distribution and CD1 loading are discussed.
De Libero G, Mori L
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Presentation of bacterial lipid antigens by CD1 molecules
Trends in Microbiology, 1998Human CD1 molecules bind and display or present lipid and glycolipid antigens from mycobacteria for recognition by T cells. Presentation requires uptake of antigen into endosomes, where it binds to CD1. T-cell recognition of CD1-presented nonpeptide antigens is a newly defined immune response that could be important for host defense against a variety ...
T I, Prigozy, M, Kronenberg
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