Results 11 to 20 of about 86,531 (200)

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

JCI Insight, 2021
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial.
C. Cero, H. Lea, K. Zhu, F. Shamsi, Y. Tseng, A. Cypess   +5 more
semanticscholar   +1 more source

Lipolysis regulates major transcriptional programs in brown adipocytes

Nature Communications, 2022
β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for oxidative metabolism.
Lasse K. Markussen, E. Rondini, O. S. Johansen, J. G. S. Madsen, E. Sustarsic, Ann-Britt Marcher, J. Hansen, Zachary Gerhart-Hines, J. Granneman, S. Mandrup   +9 more
semanticscholar   +1 more source

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis

Nature Metabolism, 2021
To liberate fatty acids (FAs) from intracellular stores, lipolysis is regulated by the activity of the lipases adipose triglyceride lipase (ATGL), hormone-sensitive lipase and monoacylglycerol lipase.
L. Ding, Wenfei Sun, Miroslav Balaz, Anyuan He, Manuel Klug, S. Wieland, R. Caiazzo, V. Raverdy, F. Pattou, P. Lefebvre, I. Lodhi, B. Staels, M. Heim, C. Wolfrum   +13 more
semanticscholar   +1 more source

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics.

Biochemical Journal, 2020
Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes.
Alexander Yang, E. Mottillo
semanticscholar   +1 more source

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nature Communications, 2015
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty ...
N. Patsoukis, Kankana Bardhan, Pranam Chatterjee, Duygu Sari, Bianling Liu, L. N. Bell, Edward D. Karoly, G. Freeman, V. Petkova, P. Seth, Lequn Li, V. Boussiotis   +11 more
semanticscholar   +1 more source

Growth and Differentiation Factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans.

JCI Insight, 2020
We hypothesized that skeletal muscle contraction produces a cellular stress signal triggering adipose tissue lipolysis to sustain fuel availability during exercise.
C. Laurens, A. Parmar, Enda E. Murphy, D. Carper, Benjamin Lair, P. Maes, Julie Vion, N. Boulet, C. Fontaine, M. Marques, D. Larrouy, I. Harant, C. Thalamas, E. Montastier, S. Caspar-Bauguil, V. Bourlier, G. Tavernier, J. Grolleau, A. Bouloumié, D. Langin, N. Viguerie, F. Bertile, S. Blanc, I. de Glisezinski, D. O'Gorman, C. Moro   +25 more
semanticscholar   +1 more source

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Nature Communications, 2020
Lipid droplets (LDs) are key subcellular organelles for regulating lipid metabolism. Although several subcellular organelles participate in lipid metabolism, it remains elusive whether physical contacts between subcellular organelles and LDs might be ...
Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, K. H. Han, J. H. Lee, Gung Lee, H. Jang, S. S. Choe, M. Baes, J. B. Kim   +10 more
semanticscholar   +1 more source

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

Journal of Cell Biology, 2019
Lipolysis and lipophagy are thought to be distinct mechanisms for lipid droplet catabolism. In hepatocytes, Schott et al. report that these pathways may operate synergistically: the lipolysis enzyme ATGL targets large LDs upstream of lipophagy, which is ...
Micah B. Schott, S. Weller, Ryan J. Schulze, E. Krueger, Kristina Drizyte-Miller, C. Casey, M. McNiven   +6 more
semanticscholar   +1 more source

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

Scientific Reports, 2019
Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota and whole-body insulin sensitivity (IS).
Mattea Müller, M. A. G. Hernández, G. Goossens, D. Reijnders, J. Holst, J. Jocken, H. van Eijk, E. E. Canfora, E. Blaak   +8 more
semanticscholar   +1 more source

Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis. [PDF]

PLoS ONE, 2016
OBJECTIVES:Numerous genetic loci have been associated with measures of central fat accumulation, such as waist-to-hip ratio adjusted for body mass index (WHRadjBMI).
Rona J Strawbridge, Helmut Laumen, Anders Hamsten, Michaela Breier, Harald Grallert, Hans Hauner, Peter Arner, Ingrid Dahlman   +7 more
doaj   +1 more source