Results 11 to 20 of about 144,905 (388)
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort [PDF]
Molecular Metabolism, 2020 Objectives: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes.
Agné Kulyté +8 more
doaj +7 more sources
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis
Nature Metabolism, 2021 To liberate fatty acids (FAs) from intracellular stores, lipolysis is regulated by the activity of the lipases adipose triglyceride lipase (ATGL), hormone-sensitive lipase and monoacylglycerol lipase.
L. Ding +13 more
semanticscholar +1 more source
The International Journal of Biochemistry & Cell Biology, 2010 Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs, is a unique function of white adipose tissue. Lipolysis in adipocytes occurs at the surface of cytosolic lipid droplets, which have recently gained much attention as dynamic organelles integral to lipid metabolism ...
Maryam Ahmadian +2 more
openaire +3 more sources
Lipolysis regulates major transcriptional programs in brown adipocytes
Nature Communications, 2022 β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for oxidative metabolism.
Lasse K. Markussen +9 more
semanticscholar +1 more source
Growth hormone stimulates lipolysis in mice but not in adipose tissue or adipocyte culture
Frontiers in Endocrinology, 2023 The inhibitory effect of growth hormone (GH) on adipose tissue growth and the stimulatory effect of GH on lipolysis are well known, but the mechanisms underlying these effects are not completely understood.
Lidan Zhao, Honglin Jiang
doaj +1 more source
Regulation of adipocyte lipolysis [PDF]
Nutrition Research Reviews, 2014 In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting conditions or times of elevated energy demands is tightly regulated by neuroendocrine signals, resulting in the activation of lipolytic enzymes. Among the classic regulators of lipolysis, adrenergic stimulation and the insulin-mediated control of lipid mobilisation ...
José-Antonio Fernández-Formoso +4 more
openaire +2 more sources
Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes [PDF]
PeerJ, 2014 We determined the effect of butyrate and other short-chain fatty acids (SCFA) on rates of lipolysis in 3T3-L1 adipocytes. Prolonged treatment with butyrate (5 mM) increased the rate of lipolysis approximately 2–3-fold.
John M. Rumberger +2 more
doaj +2 more sources
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
bioRxiv, 2021 Objective In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) acts as a lipid sensor that regulates hepatic lipid catabolism during fasting and orchestrates a genomic response required for whole-body homeostasis.
A. Fougerat +27 more
semanticscholar +1 more source
Measurement of Lipolysis [PDF]
, 2014 Lipolysis is defined as the hydrolytic cleavage of ester bonds in triglycerides (TGs), resulting in the generation of fatty acids (FAs) and glycerol. The two major TG pools in the body of vertebrates comprise intracellular TGs and plasma/nutritional TGs.
Ulrike Taschler +5 more
openaire +3 more sources