Results 11 to 20 of about 152,191 (283)

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

JCI Insight, 2021
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial.
C. Cero, H. Lea, K. Zhu, F. Shamsi, Y. Tseng, A. Cypess   +5 more
semanticscholar   +1 more source

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

bioRxiv, 2022
To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL, Pnpla2).
Ziru Li, E. Bowers, Junxiong Zhu, Hui Yu, Julie Hardij, Devika P. Bagchi, H. Mori, Kenneth T. Lewis, Katrina Granger, Rebecca L. Schill, Steven M. Romanelli, Simin H. Abrishami, K. Hankenson, K. Singer, C. Rosen, O. MacDougald   +15 more
semanticscholar   +1 more source

Brain insulin signaling suppresses lipolysis in the absence of peripheral insulin receptors and requires the MAPK pathway

Molecular Metabolism, 2023
Objectives: Insulin's ability to counterbalance catecholamine-induced lipolysis defines insulin action in adipose tissue. Insulin suppresses lipolysis directly at the level of the adipocyte and indirectly through signaling in the brain.
Matthäus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer   +5 more
doaj   +1 more source

Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis

Nature Metabolism, 2021
To liberate fatty acids (FAs) from intracellular stores, lipolysis is regulated by the activity of the lipases adipose triglyceride lipase (ATGL), hormone-sensitive lipase and monoacylglycerol lipase.
L. Ding, Wenfei Sun, Miroslav Baláž, Anyuan He, Manuel Klug, S. Wieland, R. Caiazzo, V. Raverdy, F. Pattou, P. Lefebvre, I. Lodhi, B. Staels, M. Heim, C. Wolfrum   +13 more
semanticscholar   +1 more source

Lipolysis in adipocytes [PDF]

The International Journal of Biochemistry & Cell Biology, 2010
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs, is a unique function of white adipose tissue. Lipolysis in adipocytes occurs at the surface of cytosolic lipid droplets, which have recently gained much attention as dynamic organelles integral to lipid metabolism ...
Maryam, Ahmadian, Yuhui, Wang, Hei Sook, Sul   +2 more
openaire   +2 more sources

Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase

Science, 2006
Guenter Haemmerle, Achim Lass, Robert Zimmermann, Gregor Gorkiewicz, Carola W. Meyer, Jan Rozman, Gerhard Heldmaier, Robert Maier, Christian Theussl, Sandra Eder, Dagmar Kratky, Erwin F. Wagner, Martin Klingenspor, Gerald Höefler, Rudolf Zechner   +14 more
openalex   +3 more sources

Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort

Molecular Metabolism, 2020
Objectives: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes.
Agné Kulyté, Veroniqa Lundbäck, Cecilia M. Lindgren, Jian'an Luan, Luca A. Lotta, Claudia Langenberg, Peter Arner, Rona J. Strawbridge, Ingrid Dahlman   +8 more
doaj   +1 more source

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes [PDF]

PeerJ, 2014
We determined the effect of butyrate and other short-chain fatty acids (SCFA) on rates of lipolysis in 3T3-L1 adipocytes. Prolonged treatment with butyrate (5 mM) increased the rate of lipolysis approximately 2–3-fold.
John M. Rumberger, Jonathan R.S. Arch, Allan Green   +2 more
doaj   +2 more sources

Growth hormone stimulates lipolysis in mice but not in adipose tissue or adipocyte culture

Frontiers in Endocrinology, 2023
The inhibitory effect of growth hormone (GH) on adipose tissue growth and the stimulatory effect of GH on lipolysis are well known, but the mechanisms underlying these effects are not completely understood.
Lidan Zhao, Honglin Jiang
doaj   +1 more source

Lipolysis regulates major transcriptional programs in brown adipocytes

Nature Communications, 2022
β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for oxidative metabolism.
Lasse K. Markussen, E. Rondini, O. S. Johansen, J. G. S. Madsen, E. Sustarsic, Ann-Britt Marcher, J. Hansen, Zachary Gerhart-Hines, J. Granneman, S. Mandrup   +9 more
semanticscholar   +1 more source