Targeting lipophagy and nuclear receptors in metabolic-associated fatty liver disease: insights from traditional Chinese medicine [PDF]
Frontiers in PharmacologyBackground: Metabolic associated fatty liver disease (MAFLD) represents a globally prevalent chronic hepatic disorder hallmarked by excessive lipid accumulation within hepatocytes.
Ting Yue +13 more
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PLIN3-triggered lipophagic flux releases FFAs to facilitate CSFV propagation [PDF]
VirulenceViruses hijack host metabolic resources for replication. Previous studies have shown that classical swine fever virus (CSFV) infection induces host lipid metabolic reprogramming.However, research into the exact regulatory mechanisms between CSFV and ...
Bingke Li +14 more
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The role of lipophagy in liver cancer: mechanisms and targeted therapeutic interventions [PDF]
Frontiers in Cell and Developmental BiologyLiver cancer, the advanced stage of various chronic liver diseases, has garnered attention due to its high incidence and insidious progression. Lipid droplets (LDs), unique lipid storage organelles in hepatocytes, play a pivotal role in lipid metabolism.
Peiyu Han +7 more
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Targeting Lipophagy in Liver Diseases: Impact on Oxidative Stress and Steatohepatitis [PDF]
AntioxidantsMetabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of liver conditions, from simple hepatic steatosis to its more severe inflammatory form known as metabolic dysfunction-associated steatohepatitis (MASH).
Jin Seok Hwang +2 more
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Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function [PDF]
Cell Death and DiseaseLipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD).
Yuanyuan Qin +12 more
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TM9SF1 drives the lipophagic flux via AMPK-ULK1 signaling to sustain metabolic fitness in HER2-positive breast cancer [PDF]
Cell Death and DiseaseTherapeutic resistance and recurrence in human epidermal growth factor receptor 2-positive breast cancer (HER2 + BC) remain critical challenges that portend poor patient outcomes.
Xiaofen Li +6 more
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Therapeutic potential of natural medicines in diabetic kidney disease: restoring lipid homeostasis via lipophagy modulation [PDF]
Frontiers in PharmacologyDiabetic kidney disease (DKD), one of the most prevalent microvascular complications of diabetes mellitus, is characterized by a complex pathogenesis in which lipid metabolism dysregulation plays a central role.
Junwei Gao +4 more
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The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
Frontiers in Pharmacology, 2023 Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Lipophagy is a type of programmed cell death that plays an essential role in maintaining the body’s balance of fatty acid metabolism.
Xiangyun Tan +7 more
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Cells, 2022 Recently, we developed Komagataella phaffii (formerly Pichia pastoris) as a model for lipophagy, the selective autophagy of lipid droplets (LDs). We found that lipophagy pathways induced by acute nitrogen (N) starvation and in stationary (S) phase have ...
Ravinder Kumar +2 more
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Cell Death and Disease, 2022 Autophagy is a conserved method of quality control in which cytoplasmic contents are degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid metabolism, has recently received much attention.
Sheng Zhang +11 more
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