Results 11 to 20 of about 6,907 (199)

Lipophagy and Alcohol-Induced Fatty Liver [PDF]

Frontiers in Pharmacology, 2019
This review describes the influence of ethanol consumption on hepatic lipophagy, a selective form of autophagy during which fat-storing organelles known as lipid droplets (LDs) are degraded in lysosomes.
Li Yang, Changqing Yang, Paul G. Thomes, Paul G. Thomes, Kusum K. Kharbanda, Kusum K. Kharbanda, Carol A. Casey, Carol A. Casey, Mark A. McNiven, Terrence M. Donohue, Terrence M. Donohue   +10 more
doaj   +4 more sources

Lipophagy: Molecular Mechanisms and Implications in Hepatic Lipid Metabolism

Frontiers in Bioscience-Landmark, 2023
The liver is the most significant metabolic organ in the body and plays an important role in lipid metabolism. Liver lipid metabolism disorders cause hepatic diseases such as hepatitis, hepatic cirrhosis, and hepatoma.
Sai Feng, Zeao Sun, Xiao Jia, Lingyun Li, Yijian Wu, Chengyu Wu, Ligen Lin, Jingxin Liu, Bin Zeng   +8 more
doaj   +3 more sources

Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion

Nature Communications, 2023
Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid accumulation and subsequent inflammatory and profibrotic response.
Yoshito Minami, Atsushi Hoshino, Yusuke Higuchi, Masahide Hamaguchi, Yusaku Kaneko, Yuhei Kirita, Shunta Taminishi, Toshiyuki Nishiji, Akiyuki Taruno, Michiaki Fukui, Zoltan Arany, Satoaki Matoba   +11 more
doaj   +3 more sources

Emerging Roles of Lipophagy in Health and Disease [PDF]

Frontiers in Cell and Developmental Biology, 2019
The term lipophagy is used to describe the autophagic degradation of lipid droplets, the main lipid storage organelles of eukaryotic cells. Ever since its discovery in 2009, lipophagy has emerged as a significant component of lipid metabolism with ...
Konstantinos Kounakis, Konstantinos Kounakis, Manos Chaniotakis, Manos Chaniotakis, Maria Markaki, Nektarios Tavernarakis, Nektarios Tavernarakis   +6 more
doaj   +3 more sources

Bibliometric analysis of lipophagy:2013 to 2023

Heliyon
Lipophagy is defined as the autophagic degradation of lipid droplets. It is a selective autophagy process that can continuously circulate and redistribute metabolites to maintain the body's energy balance.
Lu Zhao, Mengmeng Pang, Zhenyue Fu, Huaqin Wu, Qingqiao Song   +4 more
doaj   +3 more sources

Lipophagy: Connecting Autophagy and Lipid Metabolism [PDF]

International Journal of Cell Biology, 2012
Lipid droplets (LDs), initially considered “inert” lipid deposits, have gained during the last decade the classification of cytosolic organelles due to their defined composition and the multiplicity of specific cellular functions in which they are ...
Rajat Singh, Ana Maria Cuervo
doaj   +4 more sources

ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy

Journal of Advanced Research
Introduction: Atherosclerosis, a major contributor to cardiovascular disease, remains a significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise ...
Yuan-Mei Wang, Huang Tang, Ya-Jie Tang, Juan Liu, Yu-Fang Yin, Ya-Ling Tang, Yao-Guang Feng, Hong-Feng Gu   +7 more
doaj   +3 more sources

Inhibited Lipophagy Suppresses Lipid Metabolism in Zebrafish Liver Cells [PDF]

Frontiers in Physiology, 2019
Lipophagy degrades lipid droplets (LDs) through the lysosomal degradative pathway, thus plays important roles in regulating lipid metabolism in mammals.
Jing Wang, Si-Lan Han, Dong-Liang Lu, Ling-Yu Li, Samwel Mchele Limbu, Samwel Mchele Limbu, Dong-Liang Li, Mei-Ling Zhang, Zhen-Yu Du   +8 more
doaj   +3 more sources

FABP4-mediated lipid droplet accumulation drives epithelial-mesenchymal transition and aggravates alveolar epithelial barrier disruption. [PDF]

Clin Transl Med
LIRI induces FABP4 secretion, driving lipid droplets accumulation in alveolar epithelial cells. FABP4 activates p38 MAPK/ULK1 signalling to inhibit lipophagy and promote lipid storage. Lipid droplets trigger epithelial–mesenchymal transition and disrupt alveolar barrier. Elevated FABP4 predicts ARDS in cardiopulmonary bypass patients.
Shen Z, Qi Y, Chu M, Wu M, Feng C, Li X, Liu Z, Si L, Wang Y, Zhang J, Lu X, Lu P.   +11 more
europepmc   +2 more sources

A role for lipophagy in atherosclerosis

Nature Reviews Cardiology, 2023
Lipophagy is a type of selective autophagy that targets lipid droplets for degradation. Since the discovery of lipophagy in 2009, research has uncovered a central role for this process in cellular lipid metabolism, including in atherogenic foam cells.
Thomas Laval, Mireille Ouimet
openaire   +2 more sources