Results 51 to 60 of about 7,072 (199)
VirusesBackground: Lipids, as a fundamental cell component, play an regulating role in controlling the different cellular biological processes involved in viral infections.
Yujia Wu +4 more
doaj +1 more source
Advanced Science, EarlyView.Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen +14 more
wiley +1 more source
Hypothalamic lipophagy and energetic balance
Aging, 2011 Autophagy is a conserved cellular turnover process that degrades unwanted cytoplasmic material within lysosomes. Through "in bulk" degradation of cytoplasmic proteins and organelles, including lipid droplets, autophagy helps provide an alternative fuel source, in particular, when nutrients are scarce.
openaire +2 more sources
Alterations of Lipid Profile in Livers with Impaired Lipophagy
International Journal of Molecular Sciences, 2022 Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. Various mechanisms such as an increased uptake in fatty acids or de novo synthesis contribute to the development of steatosis and progression to more severe stages. Furthermore, it has been shown that impaired lipophagy, the degradation of lipids by
Wenke Jonas +5 more
openaire +3 more sources
External and internal triggers of cell death in yeast [PDF]
, 2016 In recent years, yeast was confirmed as a useful eukaryotic model system to decipher the complex mechanisms and networks occurring in higher eukaryotes, particularly in mammalian cells, in physiological as well in pathological conditions.
FALCONE, Claudio, MAZZONI, Cristina
core +2 more sources
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Computer‐Aided Functional Oligosaccharide Screening and the Regulatory Role in Lipid Metabolism
Food Bioengineering, EarlyView.ABSTRACT This study investigated the lipid‐lowering effects and intervention mechanisms of structurally diverse functional oligosaccharides on non‐alcoholic fatty liver disease (NAFLD). By integrating computational tools such as molecular docking and molecular dynamics simulations (MDS), a comprehensive “in silico‐in vitro‐in vivo” tri‐dimensional ...
Rui Jing +3 more
wiley +1 more source
Telemetric control of peripheral lipophagy by hypothalamic autophagy [PDF]
Autophagy, 2016 Autophagy maintains cellular quality control by degrading organelles, and cytosolic proteins and their aggregates in lysosomes. Autophagy also degrades lipid droplets (LD) through a process termed lipophagy. During lipophagy, LD are sequestered within autophagosomes and degraded by lysosomal acid lipases to generate free fatty acids that are β-oxidized
Nuria, Martinez-Lopez, Rajat, Singh
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Feeding and lipophagy: it takes guts to deliver
The EMBO Journal, 2022 Refeeding after a period of starvation is known to suppress autophagy in the liver. Surprising new work by Seok et al (2022) shows that refeeding activates lipophagy in the intestine, which may help fats in our diet to be efficiently processed after a meal.
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Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]
, 2017 Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl +19 more
core +2 more sources