Results 11 to 20 of about 26,671 (292)

Emerging biotechnologies for engineering liver organoids

Bioactive Materials
The engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao, Yue Zhi, Haozhen Ren, Jinglin Wang, Yuanjin Zhao   +4 more
doaj   +3 more sources

Liver organoids: From fabrication to application in liver diseases

Frontiers in Physiology, 2022
As the largest internal organ, the liver is the key hub for many physiological processes. Previous research on the liver has been mainly conducted on animal models and cell lines, in which not only there are deficiencies in species variability and ...
Qianglin Liu, Anqi Zeng, Zibo Liu, Chunjie Wu, Linjiang Song   +4 more
doaj   +3 more sources

Liver organoids: an in vitro 3D model for liver cancer study

Cell & Bioscience, 2022
Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally ...
Renshun Dong, Bixiang Zhang, Xuewu Zhang
doaj   +3 more sources

Next-Generation Liver Medicine Using Organoid Models [PDF]

Frontiers in Cell and Developmental Biology, 2019
“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions that cause liver failure directly or indirectly. Despite significant advances in the field of liver medicine in recent years, improved tools are needed to ...
Soheil Akbari, Nur Arslan, Nur Arslan, Serif Senturk, Serif Senturk, Esra Erdal, Esra Erdal   +6 more
doaj   +5 more sources

Progress in human liver organoids [PDF]

Journal of Molecular Cell Biology, 2020
AbstractUnderstanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an
Sun, Lulu, Hui, Lijian
openaire   +2 more sources

Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]

Biology, 2021
Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo models thus representing a turning point for studying liver disease modeling.
Caiazza C., Parisi S., Caiazzo M.
openaire   +5 more sources

Liver Organoids: Recent Developments, Limitations and Potential [PDF]

Frontiers in Medicine, 2021
Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas.
Sean Philip Harrison, Sean Philip Harrison, Saphira Felicitas Baumgarten, Saphira Felicitas Baumgarten, Rajneesh Verma, Rajneesh Verma, Oleg Lunov, Alexandr Dejneka, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan   +11 more
openaire   +5 more sources

Mechano-modulatory synthetic niches for liver organoid derivation. [PDF]

Nat Commun, 2020
AbstractThe recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modeling1–5. The use of three-dimensional (3D) cultures based on ill-defined and potentially immunogenic matrices, however, hampers the translation of liver organoid technology into real ...
Sorrentino G, Rezakhani S, Yildiz E, Nuciforo S, Heim MH, Lutolf MP, Schoonjans K.   +6 more
europepmc   +6 more sources

A Chemically Defined Hydrogel for Human Liver Organoid Culture. [PDF]

Adv Funct Mater, 2020
Ye S, Boeter JWB, Mihajlovic M, van Steenbeek FG, van Wolferen ME, Oosterhoff LA, Marsee A, Caiazzo M, Caiazzo M, van der Laan LJW, Penning LC, Vermonden T, Spee B, Schneeberger K.   +13 more
europepmc   +2 more sources

Organoid transplant approaches for the liver

Transplant International, 2021
Organoid technology is a state-of-the-art cell culture tool that has revolutionized study of development, regeneration, and diseases. Human liver organoids (HLOs) are now derived from either adult stem/progenitors or pluripotent stem cells (PSCs), emulating cellular diversity and structural symphony akin to the human liver.
Hasan Al, Reza, Ryo, Okabe, Takanori, Takebe   +2 more
openaire   +2 more sources