Results 21 to 30 of about 26,671 (292)

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip. [PDF]

Front Cell Dev Biol
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function. Researchers have attempted to develop reliable hepatic models to mimic the liver microenvironment and analyze liver function using hepatocytes cultured in the ...
Byeon JH, Jung DJ, Han HJ, Son WC, Jeong GS.   +4 more
europepmc   +4 more sources

Animal and Organoid Models of Liver Fibrosis [PDF]

Frontiers in Physiology, 2021
Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver.
Yu-long Bao, Li Wang, Hai-ting Pan, Tai-ran Zhang, Ya-hong Chen, Shan-jing Xu, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-wei Li, Shao-wei Li   +10 more
openaire   +3 more sources

Generation of human liver organoids from pluripotent stem cell-derived hepatic endoderms [PDF]

PeerJ, 2020
Background The use of a personalized liver organoid derived from human-induced pluripotent stem cells (HuiPSCs) is advancing the use of in vitro disease models for the design of specific, effective therapies for individuals. Collecting patient peripheral
Kasem Kulkeaw, Alisa Tubsuwan, Nongnat Tongkrajang, Narisara Whangviboonkij   +3 more
doaj   +2 more sources

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

Cells, 2020
The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Monique E. van Wolferen, Chen Chen, Sathidpak Nantasanti Assawarachan, Kerstin Schneeberger, Anne Kummeling, Giora van Straten, Ies C. Akkerdaas, Christel R. Vinke, Frank G. van Steenbeek, Leonie W.L. van Bruggen, Jeannette Wolfswinkel, Guy C.M. Grinwis, Sabine A. Fuchs, Helmuth Gehart, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +22 more
doaj   +1 more source

Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]

, 2013
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa, Compte, Marta, Cuesta, Ángel M., Fernández-Periáñez, Rodrigo, Guijarro-Muñoz, Irene, Molina-Privado, Irene, Rojo, Federico, Sanz, Laura, Sánchez-Martín, David, Zazo, Sandra, Álvarez-Cienfuegos, Ana, Álvarez-Méndez, Ana M., Álvarez-Vallina, Luis   +12 more
core   +10 more sources

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
openaire   +2 more sources

Human Organoids for Predictive Toxicology Research and Drug Development

Frontiers in Genetics, 2021
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
doaj   +1 more source

3D Co-Culture of Hepatocyte, a Hepatic Stellate Cell Line, and Stem Cells for Developing a Bioartificial Liver Prototype

International Journal of Technology, 2020
A liver organoid is an in vitro reconstruction of the liver that mimics the in vivo liver microstructure and performs liver functions. Liver organoids can be used for drug testing, as a model of liver disease pathogenesis, and as a bioartificial ...
Christine Verawaty Sibuea, Jeanne Pawitan, Radiana Antarianto, Cynthia O.M. Jasirwan, Imelda Rosalyn Sianipar, Evah Luviah, Retno Wahyu Nurhayati, Wildan Mubarok, Nuzli Fahdia Mazfufah   +8 more
doaj   +1 more source

Isolation and primary cultures of human intrahepatic bile ductular epithelium [PDF]

, 1988
A technique for the isolation of human intrahepatic bile ductular epithelium, and the establishment of primary cultures using a serum- and growth-factor-supplemented medium combined with a connective tissue substrata is described.
A. E. Sirica, A. G. Grant, A. J. Demetris, A. J. Demetris, A. J. Demetris, B. H. Markus, C. Petropoulos, D. C. Snover, H. O. Jauregni, H. Yoshimura, J. J. Fung, J. W. Grisham, J. W. Grisham, J. W. Grisham, L. M. Ried, L. Makowka, N. Fausto, N. T. Hayner, R. Duquesnoy, R. N. M. MacSween, S. Graner, S. L. Hammond, S. Saidman, T. E. Starzl, T. Ming-Sound   +24 more
core   +1 more source

Applied Hepatic Bioengineering: Modeling the Human Liver Using Organoid and Liver-on-a-Chip Technologies

Frontiers in Bioengineering and Biotechnology, 2022
The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may produce inconclusive results for predicting clinical outcomes in humans, moreover ...
Kayque Alves Telles-Silva, Lara Pacheco, Sabrina Komatsu, Fernanda Chianca, Luiz Carlos Caires-Júnior, Bruno Henrique Silva Araujo, Ernesto Goulart, Mayana Zatz   +7 more
doaj   +1 more source