Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling [PDF]
Stem Cell Research & TherapyThe lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applications.
Weidong Shao +5 more
doaj +4 more sources
Liver organoids and their application in liver cancer research [PDF]
Regenerative Therapy, 2023 Liver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods.
Xinyu Song +5 more
doaj +3 more sources
Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis [PDF]
Stem Cell Reports, 2017 Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen +20 more
doaj +3 more sources
Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]
Biology, 2021 Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo
Carmen Caiazza +2 more
doaj +2 more sources
Emerging biotechnologies for engineering liver organoids [PDF]
Bioactive MaterialsThe engineering construction of the liver has attracted enormous attention. Organoids, as emerging miniature three-dimensional cultivation units, hold significant potential in the biomimetic simulation of liver structure and function.
Junqi Zhao +4 more
doaj +2 more sources
A decade of liver organoids: Advances in disease modeling [PDF]
Clinical and Molecular Hepatology, 2023 Liver organoids are three-dimensional cellular tissue models in which cells interact to form unique structures in culture. During the past 10 years, liver organoids with various cellular compositions, structural features, and functional properties have ...
Yue Liu +4 more
doaj +2 more sources
Efficient and reproducible generation of human induced pluripotent stem cell-derived expandable liver organoids for disease modeling [PDF]
Scientific Reports, 2023 Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems.
Seon Ju Mun +7 more
doaj +2 more sources
Prediction for oxaliplatin‐induced liver injury using patient‐derived liver organoids [PDF]
Cancer MedicineBackground Liver injury associated with oxaliplatin (L‐OHP)‐based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery.
Kumiko Tatsumi +12 more
doaj +2 more sources
Bioengineering Liver Organoids for Diseases Modelling and Transplantation [PDF]
Bioengineering, 2022 Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications.
Junzhi Li +5 more
doaj +2 more sources
Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation [PDF]
BMC BiologyBackground Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic metabolism transformation.
Shaoyu Zhong +7 more
doaj +2 more sources