Results 11 to 20 of about 35,405 (287)

Generation of in vivo-like multicellular liver organoids by mimicking developmental processes: A review [PDF]

Regenerative Therapy
Liver is involved in metabolic reactions, ammonia detoxification, and immunity. Multicellular liver tissue cultures are more desirable for drug screening, disease modeling, and researching transplantation therapy, than hepatocytes monocultures ...
Ayumu Okumura, Kenji Aoshima, Naoki Tanimizu   +2 more
doaj   +2 more sources

Scalable production of tissue-like vascularized liver organoids from human PSCs. [PDF]

Exp Mol Med, 2023
Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS, Boger IC, Bogen IL, Nyman TA, Wu JJ, Bezrouk A, Cizkova D, Corral J, Mokry J, Zweigerdt R, Park IH, Sullivan GJ.   +35 more
europepmc   +3 more sources

Human liver organoids are susceptible to Plasmodium vivax infection [PDF]

Malaria Journal
Background The eradication of Plasmodium vivax malaria is complicated due to the presence of hypnozoites, the hidden dormant form of the parasite that is present in the liver.
Norapat Nitaramorn, Porntida Kobpornchai, Nongnat Tongkrajang, Urai Chaisri, Mallika Imwong, Kasem Kulkeaw   +5 more
doaj   +2 more sources

Using Liver Organoids as Models to Study the Pathobiology of Rare Liver Diseases [PDF]

Biomedicines
Liver organoids take advantage of several important features of pluripotent stem cells that self-assemble in a three-dimensional culture matrix and reproduce many aspects of the complex organization found within their native tissue or organ counterparts.
Dalia A. Obeid, Tanveer Ahmad Mir, Alaa Alzhrani, Abdullah Altuhami, Talal Shamma, Sana Ahmed, Shadab Kazmi, Iriya Fujitsuka, Mohd Ikhlaq, Mohammad Shabab, Abdullah M. Assiri, Dieter C. Broering   +11 more
doaj   +2 more sources

Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids. [PDF]

Cell Rep Med
Kawamura S, Yoneyama Y, Saiki N, Wu Y, Moriya C, Ohmura R, Maezawa M, Shimada Y, Wang Y, Mori K, Okada N, Onishi Y, Sanada Y, Hirata Y, Sakuma Y, Takebe T.   +15 more
europepmc   +2 more sources

Modeling metabolic-associated steatohepatitis with human pluripotent stem cell-derived liver organoids. [PDF]

Hepatol Commun
Wu X, Jiang D, Wang Y, Li X, Liu C, Chen Y, Sun W, He R, Yang Y, Gu X, Jiang C, Ding Q.   +11 more
europepmc   +2 more sources

Chronotoxici-Plate Containing Droplet-Engineered Rhythmic Liver Organoids for Drug Toxicity Evaluation. [PDF]

Adv Sci (Weinh)
Zhou J, Huang YC, Wang W, Li J, Hou Y, Yi Z, Yang H, Hu K, Zhu Y, Wang Z, Ma S.   +10 more
europepmc   +3 more sources

Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids. [PDF]

Front Pharmacol, 2023
Elbadawy M, Tanabe K, Yamamoto H, Ishihara Y, Mochizuki M, Abugomaa A, Yamawaki H, Kaneda M, Usui T, Sasaki K.   +9 more
europepmc   +3 more sources

A simplified method for immunostaining single endometrial and liver organoids. [PDF]

J Genet Eng Biotechnol
Saadeldin IM, Alshehri E, AlThubyani M, Almohanna F, Matic G, Ahmed HA, Mir TA, Assiri AM.   +7 more
europepmc   +2 more sources

Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids [PDF]

Toxins
Biliary atresia (BA) is a poorly understood and devastating obstructive bile duct disease of newborns. Biliatresone, a plant toxin, causes BA-like syndrome in some animals, but its relevance in humans is unknown.
Yue Hai-Bing, Menon Sudheer Sivasankaran, Babu Rosana Ottakandathil, Wu Zhong-Luan, So Man-Ting, Chung (Patrick) Ho-Yu, Wong (Kenneth) Kak-Yuen, Tam (Paul) Kwong-Hang, Lui (Vincent) Chi-Hang   +8 more
doaj   +2 more sources