Results 11 to 20 of about 23,262 (271)

Using Liver Organoids as Models to Study the Pathobiology of Rare Liver Diseases [PDF]

Biomedicines
Liver organoids take advantage of several important features of pluripotent stem cells that self-assemble in a three-dimensional culture matrix and reproduce many aspects of the complex organization found within their native tissue or organ counterparts.
Dalia A. Obeid, Tanveer Ahmad Mir, Alaa Alzhrani, Abdullah Altuhami, Talal Shamma, Sana Ahmed, Shadab Kazmi, Iriya Fujitsuka, Mohd Ikhlaq, Mohammad Shabab, Abdullah M. Assiri, Dieter C. Broering   +11 more
doaj   +3 more sources

Liver Organoids: Updates on Disease Modeling and Biomedical Applications [PDF]

Biology, 2021
Liver organoids are stem cell-derived 3D structures that are generated by liver differentiation signals in the presence of a supporting extracellular matrix. Liver organoids overcome low complexity grade of bidimensional culture and high costs of in vivo
Carmen Caiazza, Silvia Parisi, Massimiliano Caiazzo   +2 more
doaj   +5 more sources

Liver organoids: established tools for disease modeling and drug development

Hepatology Communications, 2023
In the past decade, liver organoids have evolved rapidly as valuable research tools, providing novel insights into almost all types of liver diseases, including monogenic liver diseases, alcohol-associated liver disease, metabolic-associated fatty liver disease, various types of (viral) hepatitis, and liver cancers.
Xi-Cheng Sun, De-fu Kong, Jie Zhao, Klaas Nico Faber, Qiang Xia, Kang He   +5 more
openaire   +3 more sources

Liver organoids: From fabrication to application in liver diseases

Frontiers in Physiology, 2022
As the largest internal organ, the liver is the key hub for many physiological processes. Previous research on the liver has been mainly conducted on animal models and cell lines, in which not only there are deficiencies in species variability and ...
Qianglin Liu, Anqi Zeng, Zibo Liu, Chunjie Wu, Linjiang Song   +4 more
doaj   +3 more sources

Fast formation and maturation enhancement of human liver organoids using a liver-organoid-on-a-chip. [PDF]

Front Cell Dev Biol
Background: Spatial and functional hepatic zonation, established by the heterogeneous tissue along the portal–central axis of the liver, is important for ensuring optimal liver function. Researchers have attempted to develop reliable hepatic models to mimic the liver microenvironment and analyze liver function using hepatocytes cultured in the ...
Byeon JH, Jung DJ, Han HJ, Son WC, Jeong GS.   +4 more
europepmc   +5 more sources

Efficient and reproducible generation of human induced pluripotent stem cell-derived expandable liver organoids for disease modeling

Scientific Reports, 2023
Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems.
Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Jaeseo Lee, Hyun-Soo Cho, Dae-Soo Kim, Kyung-Sook Chung, Myung Jin Son   +7 more
doaj   +2 more sources

Human liver organoids: From generation to applications. [PDF]

Hepatology, 2023
In the last decade, research into human hepatology has been revolutionized by the development of mini human livers in a dish. These liver organoids are formed by self-organizing stem cells and resemble their native counterparts in cellular content, multicellular architecture, and functional features. Liver organoids can be derived from the liver tissue
Afonso MB, Marques V, van Mil SWC, Rodrigues CMP.   +3 more
europepmc   +5 more sources

Next-Generation Liver Medicine Using Organoid Models [PDF]

Frontiers in Cell and Developmental Biology, 2019
“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions that cause liver failure directly or indirectly. Despite significant advances in the field of liver medicine in recent years, improved tools are needed to ...
Soheil Akbari, Nur Arslan, Nur Arslan, Serif Senturk, Serif Senturk, Esra Erdal, Esra Erdal   +6 more
doaj   +5 more sources

Organoids to model liver disease [PDF]

JHEP Reports, 2021
The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods.
Nuciforo, Sandro, Heim, Markus H.
openaire   +2 more sources

Emerging liver organoid platforms and technologies [PDF]

Cell Regeneration, 2021
AbstractBuilding human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug metabolism.
Do Thuy Uyen Ha Lam, Yock Young Dan, Yun-Shen Chan, Huck-Hui Ng   +3 more
openaire   +3 more sources