Results 211 to 220 of about 35,405 (287)

Advances, challenges and future applications of liver organoids in experimental regenerative medicine. [PDF]

Front Med (Lausanne)
Gong D, Mo J, Zhai M, Zhou F, Wang G, Ma S, Dai X, Deng X.   +7 more
europepmc   +1 more source

Integrative multi-omics of matched primary and liver metastatic colorectal cancer organoids identifies putative molecular targets

Chae-Young Kim, Soon‐Chan Kim, Rumi Shin, Min Jung Kim, Seung‐Yong Jeong, Ji Won Park, Ja‐Lok Ku   +6 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

From gut to liver: organoids as platforms for next-generation toxicology assessment vehicles for xenobiotics. [PDF]

Stem Cell Res Ther
Alnasser SM.
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Engineering a dynamic extracellular matrix using thrombospondin-1 to propel hepatocyte organoids reprogramming and improve mouse liver regeneration post-transplantation

Ziyan Xu, Min Wang, Jingyan Shi, Ye Liu, Chao Yu, Xinyi Zhang, Chenwei Zhang, Qifeng He, Chao Pan, Jin Zhou, Hua Xiao, Hongyong Cao, Yong Ma   +12 more
openalex   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Misidentification of neural cell identity in liver-derived organoid systems [PDF]

Imre F. Schene, Arif Ibrahim Ardisasmita, Sabine A. Fuchs   +2 more
openalex   +1 more source

NASH patient liver derived organoids exhibit patient specific NASH phenotypes and drug responses [PDF]

, 2019
Sarah L. McCarron, Brooke Bathon, Deepti Abbey, Donna Conlon, Daniel J. Rader, Kim M. Olthoff, Abraham Shaked, Tobias Raabe   +7 more
openalex   +1 more source

Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro [PDF]

, 2019
KIKUCHI Tetsutaro, SEKIYA Sachiko, SHIMIZU Tatsuya   +2 more
core   +2 more sources