Results 21 to 30 of about 23,262 (271)

Progress in human liver organoids [PDF]

Journal of Molecular Cell Biology, 2020
AbstractUnderstanding the development, regeneration, and disorders of the liver is the major goal in liver biology. Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines, which fall short in recapitulating the features of human liver cells or the structures and functions of human livers. Organoids as an
Sun, Lulu, Hui, Lijian
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Recent advances in liver organoids and their use in modeling of non-alcoholic fatty liver disease [PDF]

Organoid, 2022
The liver is involved in physiological activities critical for survival. Chronic liver disease (CLD) frequently progresses to life-threatening liver failure, as evidenced by CLD patients’ high morbidity and mortality rates.
Kyun Yoo Chi, Jong-Hoon Kim
doaj   +1 more source

Liver Organoids: Recent Developments, Limitations and Potential [PDF]

Frontiers in Medicine, 2021
Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas.
Sean Philip Harrison, Sean Philip Harrison, Saphira Felicitas Baumgarten, Saphira Felicitas Baumgarten, Rajneesh Verma, Rajneesh Verma, Oleg Lunov, Alexandr Dejneka, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan, Gareth John Sullivan   +11 more
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Liver organoid culture methods

Cell & Bioscience, 2023
AbstractOrganoids, three-dimensional structures cultured in vitro, can recapitulate the microenvironment, complex architecture, and cellular functions of in vivo organs or tissues. In recent decades, liver organoids have been developed rapidly, and their applications in biomedicine, such as drug screening, disease modeling, and regenerative medicine ...
Yiqing Hu, Xiaoyi Hu, Jia Luo, Jiacheng Huang, Yaohan Sun, Haoyu Li, Yinbiao Qiao, Hao Wu, Jianhui Li, Lin Zhou, Shusen Zheng   +10 more
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High-throughput bioengineering of homogenous and functional human-induced pluripotent stem cells-derived liver organoids via micropatterning technique

Frontiers in Bioengineering and Biotechnology, 2022
Human pluripotent stem cell-derived liver organoids are emerging as more human-relevant in vitro models for studying liver diseases and hepatotoxicity than traditional hepatocyte cultures and animal models.
Xiaodong Xu, Xiaodong Xu, Shanqing Jiang, Longjun Gu, Bin Li, Fang Xu, Changyong Li, Pu Chen, Pu Chen, Pu Chen   +9 more
doaj   +1 more source

From gut to liver: organoids as platforms for next-generation toxicology assessment vehicles for xenobiotics. [PDF]

Stem Cell Res Ther
Traditional toxicological assessment relied heavily on 2D cell cultures and animal models of study, which were inadequate for the precise prediction of human response to chemicals.
Alnasser SM.
europepmc   +2 more sources

Multi-zonal liver organoids from human pluripotent stem cells. [PDF]

Nature
Reza HA, Santangelo C, Iwasawa K, Reza AA, Sekiya S, Glaser K, Bondoc A, Merola J, Takebe T.   +8 more
europepmc   +2 more sources

9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids. [PDF]

Cells
Liver fibrosis majorly impacts global health, necessitating the development of in vitro models to study disease mechanisms and develop drug therapies. Relevant models should at least include hepatocytes and hepatic stellate cells (HSCs) and ideally use ...
Kazemzadeh Dastjerd M, Merens V, Smout A, De Wolf R, Chesné C, Verfaillie C, Verhulst S, van Grunsven LA.   +7 more
europepmc   +2 more sources

Advances, challenges and future applications of liver organoids in experimental regenerative medicine. [PDF]

Front Med (Lausanne)
The liver is a vital organ responsible for numerous metabolic processes in the human body, including the metabolism of drugs and nutrients. After liver damage, the organ can rapidly return to its original size if the causative factor is promptly ...
Gong D, Mo J, Zhai M, Zhou F, Wang G, Ma S, Dai X, Deng X.   +7 more
europepmc   +2 more sources

Human liver organoid: modeling liver steatosis and beyond

Cell Regeneration, 2023
AbstractSteatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure without intervention. Despite the development of animal models, there is still a lack of the human-relevant platform for steatosis modeling and drug & target discovery.
Jinsong Wei, Wen Zhang, Bing Zhao
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