Results 31 to 40 of about 23,262 (271)

Developing Biliary Atresia-like Model by Treating Human Liver Organoids with Polyinosinic:Polycytidylic Acid (Poly (I:C))

Current Issues in Molecular Biology, 2022
Background: We explored the feasibility of creating BA-like organoids by treating human liver organoids with Polyinosinic:Polycytidylic acid (Poly I:C).
Patrick Ho-Yu Chung, Rosana Ottakandathil Babu, Zhongluan Wu, Kenneth Kak-Yuen Wong, Paul Kwong-Hang Tam, Vincent Chi-Hang Lui   +5 more
doaj   +1 more source

Generation of Fibrotic Liver Organoids Using Hepatocytes, Primary Liver Sinusoidal Endothelial Cells, Hepatic Stellate Cells, and Macrophages

Cells, 2023
Liver organoids generated with single or multiple cell types have been used to investigate liver fibrosis development, toxicity, pathogenesis, and drug screening.
Yongdae Yoon, Seong Chan Gong, Moon Young Kim, Soon Koo Baik, Ju-Eun Hong, Ki-Jong Rhee, Hoon Ryu, Young Woo Eom   +7 more
doaj   +1 more source

Integrative analysis of single-cell RNA-seq and ATAC-seq reveals heterogeneity of induced pluripotent stem cell-derived hepatic organoids

iScience, 2023
Summary: To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states (expandable and more differentiated) were subjected to single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) analyses ...
Jong-Hwan Kim, Seon Ju Mun, Jeong-Hwan Kim, Myung Jin Son, Seon-Young Kim   +4 more
doaj   +1 more source

Organoid transplant approaches for the liver

Transplant International, 2021
Organoid technology is a state-of-the-art cell culture tool that has revolutionized study of development, regeneration, and diseases. Human liver organoids (HLOs) are now derived from either adult stem/progenitors or pluripotent stem cells (PSCs), emulating cellular diversity and structural symphony akin to the human liver.
Hasan Al, Reza, Ryo, Okabe, Takanori, Takebe   +2 more
openaire   +2 more sources

Animal and Organoid Models of Liver Fibrosis [PDF]

Frontiers in Physiology, 2021
Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver.
Yu-long Bao, Li Wang, Hai-ting Pan, Tai-ran Zhang, Ya-hong Chen, Shan-jing Xu, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-wei Li, Shao-wei Li   +10 more
openaire   +3 more sources

Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

Biomolecules, 2021
The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and ...
Xv Zhang, Liling Tang, Qian Yi
doaj   +1 more source

Liver organoids: Current advances and future applications for hepatology. [PDF]

Clin Mol Hepatol
The creation of self-organizing liver organoids represents a significant, although modest, step toward addressing the ongoing organ shortage crisis in allogeneic liver transplantation.
Kim Y, Kang M, Mamo MG, Adisasmita M, Huch M, Choi D.   +5 more
europepmc   +2 more sources

Hepatitis C virus infects and perturbs liver stem cells

mBio, 2023
Hepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk remains unclear.
Nathan L. Meyers, Tal Ashuach, Danielle E. Lyons, Mir M. Khalid, Camille R. Simoneau, Ann L. Erickson, Mehdi Bouhaddou, Thong T. Nguyen, G. Renuka Kumar, Taha Y. Taha, Vaishaali Natarajan, Jody L. Baron, Norma Neff, Fabio Zanini, Tokameh Mahmoudi, Stephen R. Quake, Nevan J. Krogan, Stewart Cooper, Todd C. McDevitt, Nir Yosef, Melanie Ott   +20 more
doaj   +1 more source

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

eLife, 2021
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system.
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi   +22 more
doaj   +1 more source

Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism. [PDF]

Toxicol Res
Kim H, Park HJ.
europepmc   +2 more sources