Results 41 to 50 of about 23,262 (271)

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells [PDF]

Organoid, 2022
Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease.
Min Jung Kim, Jaeseo Lee, Seon Ju Mun, Myung Jin Son, Jung-Hyun Kim   +4 more
doaj   +1 more source

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

Stem Cell Reports, 2017
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +20 more
doaj   +1 more source

Liver organoids: updates on generation strategies and biomedical applications. [PDF]

Stem Cell Res Ther
The liver is the most important metabolic organ in the body. While mouse models and cell lines have further deepened our understanding of liver biology and related diseases, they are flawed in replicating key aspects of human liver tissue, particularly ...
Liu S, Cheng C, Zhu L, Zhao T, Wang Z, Yi X, Yan F, Wang X, Li C, Cui T, Yang B.   +10 more
europepmc   +2 more sources

Scalable production of tissue-like vascularized liver organoids from human PSCs. [PDF]

Exp Mol Med, 2023
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver.
Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS, Boger IC, Bogen IL, Nyman TA, Wu JJ, Bezrouk A, Cizkova D, Corral J, Mokry J, Zweigerdt R, Park IH, Sullivan GJ.   +35 more
europepmc   +2 more sources

Organoids for the Study of Liver Cancer

Seminars in Liver Disease, 2021
AbstractLiver cancer is the second most lethal malignancy worldwide. Cell lines and murine models are the most common tools for modeling human liver carcinogenesis. Most recently, organoids with a three-dimensional structure derived from primary tissues or cells have been applied to liver cancer research.
Wang, Haichuan, Calvisi, Diego, Chen, Xin   +2 more
openaire   +5 more sources

Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model

Cell Transplantation, 2020
Transplantation of liver organoids has been investigated as a treatment alternative to liver transplantation for chronic liver disease. Transportal approach can be considered as a method of delivering organoids to the liver.
Tomonori Tsuchida, Soichiro Murata, Shunsuke Hasegawa, Satoshi Mikami, Shin Enosawa, Huai-Che Hsu, Akinari Fukuda, Satoshi Okamoto, Akihiro Mori, Megumi Matsuo, Yumi Kawakatsu, Hitomi Matsunari, Kazuaki Nakano, Hiroshi Nagashima, Hideki Taniguchi   +14 more
doaj   +1 more source

Liver Decellularization as Liver Organoid Reconstruction Scaffold

Buletin Farmatera, 2021
Abstrak Pendekatan terbaru dalam teknik rekayasa jaringan adalah penggunaan organ asal yang telah dideselularisasi sebagai scaffold (rangka) untuk rekonstruksi organ. Scaffold yang terbuat dari matriks alami ataupun sintetis memiliki banyak keterbatasan dalam memberikan mikrostruktur matriks ekstraseluler yang ideal untuk proliferasi dan ...
openaire   +2 more sources

Microengineered Multi‐Organoid System from hiPSCs to Recapitulate Human Liver‐Islet Axis in Normal and Type 2 Diabetes

Advanced Science, 2022
Type 2 diabetes mellitus (T2DM) is a systematic multi‐organ metabolic disease, which is characterized by the dynamic interplay among different organs. The increasing incidence of T2DM reflects an urgent need for the development of in vitro human‐relevant
Tingting Tao, Pengwei Deng, Yaqing Wang, Xu Zhang, Yaqiong Guo, Wenwen Chen, Jianhua Qin   +6 more
doaj   +1 more source

Innovations in liver organoids: the role of 3D bioprinting in creating functional organoids. [PDF]

Hepatobiliary Surg Nutr
Zhang K, Yang H.
europepmc   +3 more sources

Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting. [PDF]

Lab Chip
Human liver organoids (HLOs) hold significant potential for recapitulating the architecture and function of liver tissues in vivo. However, conventional culture methods of HLOs, forming Matrigel domes in 6-/24-well plates, have technical limitations such
Shrestha S, Lekkala VKR, Acharya P, Kang SY, Vanga MG, Lee MY.   +5 more
europepmc   +2 more sources