Results 51 to 60 of about 23,262 (271)

Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts [PDF]

Biomaterials, 2021
AbstractThree-dimensional scaffolds decellularized from native organs are a promising technique to establish engineered liver grafts and overcome the current shortage of donor organs. However, limited sources of bile duct cells and inappropriate cell distribution in bioengineered liver grafts have hindered their practical application.
Katsuhiro Tomofuji, Ken Fukumitsu, Jumpei Kondo, Hiroshi Horie, Kenta Makino, Satoshi Wakama, Takashi Ito, Yu Oshima, Satoshi Ogiso, Takamichi Ishii, Masahiro Inoue, Etsuro Hatano   +11 more
openaire   +2 more sources

Updates on Organoid Model for the Study of Liver Cancer

Technology in Cancer Research & Treatment, 2023
Liver cancer remains one of the most common cancers worldwide with limited therapy options. The main risk factors for hepatocellular carcinoma (HCC), the most common form of liver cancer, include chronic infection with hepatitis B or hepatitis C viruses,
Korri E. El-Khobar PhD, Caecilia H. C. Sukowati PhD   +1 more
doaj   +1 more source

Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

Stem Cell Research, 2018
Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture ...
Jon N. Buzzelli, Djamila Ouaret, Graham Brown, Philip D. Allen, Ruth J. Muschel   +4 more
doaj   +1 more source

Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation

Technology in Cancer Research & Treatment, 2023
Background To assess the radiosensitivity of liver tumors harboring different genetic mutations, mouse liver tumors were generated in vivo through the hydrodynamic injection of clustered regularly interspaced short palindromic repeat/caspase 9 (CRISPR ...
Wan Jeon MD, Se Yeon Jung PhD, Chae Young Lee PhD, Won-Tae Kim PhD, Hyun Kim PhD, Kyoung Won Jang PhD, Heuijin Lim PhD, Manwoo Lee PhD, Dong Hyeok Jeong PhD, Sung Dae Kim PhD, In Ah Kim PhD, MD, Si Ho Choi PhD, Tae Gen Son PhD, Kyung Su Kim PhD, MD   +13 more
doaj   +1 more source

Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease [PDF]

Hepatology International, 2019
Abstract Background and aims Alpha-1 antitrypsin (AAT) is a product of SERPINA1 gene mainly expressed by hepatocytes. Clinically relevant mutations in the SERPINA1 gene, such as Z (Glu342Lys), results in an expression of misfolded AAT protein having high propensity to polymerize, accumulate in hepatocytes and thus to ...
Gómez-Mariano, Gema, Matamala, Nerea, Martínez, Selene, Justo, Iago, Marcacuzco, Alberto, Jimenez, Carlos, Monzón, Sara, Cuesta, Isabel, Garfia, Cristina, Martínez, María Teresa, Huch, Meritxell, Pérez De Castro, Ignacio, Posada, Manuel, Janciauskiene, Sabina, Martínez-Delgado, Beatriz   +14 more
openaire   +4 more sources

The application of liver cancer organoids in tumour precision medicine: A comprehensive review

iLIVER
Liver cancer is a leading cause of cancer-related death worldwide, and its complexity and heterogeneity pose considerable challenges to conventional treatment.
Jiaye Mo, Da Gong, Mei Zhai, Jintao Yang, Zhike Li, Meilong Wu, Xuesong Deng, Xiaoyong Dai   +7 more
doaj   +1 more source

Human liver organoids are susceptible to Plasmodium vivax infection. [PDF]

Malar J
The eradication of Plasmodium vivax malaria is complicated due to the presence of hypnozoites, the hidden dormant form of the parasite that is present in the liver.
Nitaramorn N, Kobpornchai P, Tongkrajang N, Chaisri U, Imwong M, Kulkeaw K.   +5 more
europepmc   +2 more sources

Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling

Stem cell research & therapeutics, 2023
Background The generation of liver organoids recapitulating parenchymal and non-parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases.
Hyo-Jin Kim, Gyeongmin Kim, Kyun Yoo Chi, Hyemin Kim, Y. Jang, Seongyea Jo, Jihun Lee, Youngseok Lee, Dong-Hun Woo, C. Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim   +12 more
semanticscholar   +1 more source

Chronotoxici-Plate Containing Droplet-Engineered Rhythmic Liver Organoids for Drug Toxicity Evaluation. [PDF]

Adv Sci (Weinh)
The circadian clock coordinates the daily rhythmicity of biological processes, and its dysregulation is associated with various human diseases. Despite the direct targeting of rhythmic genes by many prevalent and World Health Organization (WHO) essential
Zhou J, Huang YC, Wang W, Li J, Hou Y, Yi Z, Yang H, Hu K, Zhu Y, Wang Z, Ma S.   +10 more
europepmc   +2 more sources

Cellular expansion of hepatocellular carcinoma organoids using decellularized liver scaffolds

Clinical Transplantation and Research
Background : A decellularized liver scaffold (DLS) is a three-dimensional acellular extracellular matrix created by removing cellular components from liver tissue. Hepatocellular carcinoma (HCC) organoids represent a useful experimental model.
Shin Hwang, I-Ji Jung, Kyoung-Jin Lee, Yun-Kyu Kim, Eunyoung Tak   +4 more
doaj   +1 more source