Results 41 to 50 of about 173,449 (258)

MALAT1 Long Non-Coding RNA: Functional Implications

Non-Coding RNA, 2020
The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated.
Gayatri Arun, Disha Aggarwal, David L. Spector   +2 more
doaj   +1 more source

Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Non-Coding RNA, 2022
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year ...
Adrienne Vancura, Alejandro H. Gutierrez, Thorben Hennig, Carlos Pulido-Quetglas, Frank J. Slack, Rory Johnson, Simon Haefliger   +6 more
doaj   +1 more source

NONCODE v3.0: integrative annotation of long noncoding RNAs [PDF]

Nucleic Acids Research, 2011
Facilitated by the rapid progress of high-throughput sequencing technology, a large number of long noncoding RNAs (lncRNAs) have been identified in mammalian transcriptomes over the past few years. LncRNAs have been shown to play key roles in various biological processes such as imprinting control, circuitry controlling pluripotency and differentiation,
Bu, Dechao, Yu, Kuntao, Sun, Silong, Xie, Chaoyong, Skogerbø, Geir, Miao, Ruoyu, Xiao, Hui, Liao, Qi, Luo, Haitao, Zhao, Guoguang, Zhao, Haitao, Liu, Zhiyong, Liu, Changning, Chen, Runsheng, Zhao, Yi   +14 more
openaire   +2 more sources

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network [PDF]

, 2019
Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their
Alessio, Enrico, Bertoli, Alessandro, Buson, Lisa, Cagnin, Stefano, Chemello, Francesco, Grespi, Francesca, Lanfranchi, Gerolamo, Martini, Paolo, Massimino, Maria L, Millino, Caterina, Pacchioni, Beniamina, Peggion, Caterina, Romualdi, Chiara, Scorrano, Luca   +13 more
core   +1 more source

Long noncoding RNAs and neuroblastoma

Oncotarget, 2015
Neuroblastoma is a disease that affects infants and despite intense multimodal therapy, high-risk patients have low survival rates (
Gaurav Kumar, Pandey, Chandrasekhar, Kanduri   +1 more
openaire   +3 more sources

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

Long Noncoding RNAs in Atherosclerosis

Journal of Atherosclerosis and Thrombosis, 2016
Long noncoding RNAs (lncRNAs) were a group of non-protein-coding RNAs ＞200 nucleotides and participated in biological processes and pathophysiological conditions in vivo or in vitro. Recently, more and more lncRNAs interfering with the progress of atherosclerosis were identified and characterized in the atherogenic cells such as vascular smooth muscle ...
Liguo, Jian, Dongdong, Jian, Qishan, Chen, Li, Zhang   +3 more
openaire   +3 more sources

Long, Noncoding RNA Dysregulation in Glioblastoma [PDF]

Cancers, 2021
Transcription occurs across more than 70% of the human genome and more than half of currently annotated genes produce functional noncoding RNAs. Of these transcripts, the majority—long, noncoding RNAs (lncRNAs)—are greater than 200 nucleotides in length and are necessary for various roles in the cell.
Patrick A. DeSouza, Xuan Qu, Hao Chen, Bhuvic Patel, Christopher A. Maher, Albert H. Kim   +5 more
openaire   +3 more sources

The how and why of lncRNA function: An innate immune perspective. [PDF]

, 2020
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan, Covarrubias, Sergio, Robinson, Elektra K   +2 more
core  

Long noncoding RNAs in prostate cancer: overview and clinical implications. [PDF]

, 2016
Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to ...
Feng, Felix Y, Malik, Bhavna
core   +3 more sources