Results 41 to 50 of about 162,179 (208)

Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Non-Coding RNA, 2022
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year ...
Adrienne Vancura, Alejandro H. Gutierrez, Thorben Hennig, Carlos Pulido-Quetglas, Frank J. Slack, Rory Johnson, Simon Haefliger   +6 more
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

A novel lncRNA as a positive regulator of carotenoid biosynthesis in Fusarium [PDF]

, 2020
The fungi Fusarium oxysporum and Fusarium fujikuroi produce carotenoids, lipophilic terpenoid pigments of biotechnological interest, with xanthophyll neurosporaxanthin as the main end product.
Gutiérrez Pozo, Gabriel, Limón Mirón, María del Carmen, Pardo Medina, Javier, Parra Rivero, Obdulia, Ávalos Cordero, Francisco Javier   +4 more
core   +1 more source

NONCODE v3.0: integrative annotation of long noncoding RNAs [PDF]

Nucleic Acids Research, 2011
Facilitated by the rapid progress of high-throughput sequencing technology, a large number of long noncoding RNAs (lncRNAs) have been identified in mammalian transcriptomes over the past few years. LncRNAs have been shown to play key roles in various biological processes such as imprinting control, circuitry controlling pluripotency and differentiation,
Bu, Dechao, Yu, Kuntao, Sun, Silong, Xie, Chaoyong, Skogerbø, Geir, Miao, Ruoyu, Xiao, Hui, Liao, Qi, Luo, Haitao, Zhao, Guoguang, Zhao, Haitao, Liu, Zhiyong, Liu, Changning, Chen, Runsheng, Zhao, Yi   +14 more
openaire   +2 more sources

A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. [PDF]

, 2016
Gonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal reproductive development and function ...
Brusman, Liza E, Huang, Polly P, Iyer, Anita K, Mellon, Pamela L, Webster, Nicholas JG   +4 more
core   +2 more sources

Long noncoding RNAs and neuroblastoma

Oncotarget, 2015
Neuroblastoma is a disease that affects infants and despite intense multimodal therapy, high-risk patients have low survival rates (
Gaurav Kumar, Pandey, Chandrasekhar, Kanduri   +1 more
openaire   +3 more sources

Long non-coding RNA SOX2OT: Expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis [PDF]

, 2015
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region.
Jazi, M.S., Mowla, S.J., Samaei, N.M., Shahryari, A.   +3 more
core   +1 more source

Long Noncoding RNAs in Atherosclerosis

Journal of Atherosclerosis and Thrombosis, 2016
Long noncoding RNAs (lncRNAs) were a group of non-protein-coding RNAs ＞200 nucleotides and participated in biological processes and pathophysiological conditions in vivo or in vitro. Recently, more and more lncRNAs interfering with the progress of atherosclerosis were identified and characterized in the atherogenic cells such as vascular smooth muscle ...
Liguo, Jian, Dongdong, Jian, Qishan, Chen, Li, Zhang   +3 more
openaire   +3 more sources

Long, Noncoding RNA Dysregulation in Glioblastoma [PDF]

Cancers, 2021
Transcription occurs across more than 70% of the human genome and more than half of currently annotated genes produce functional noncoding RNAs. Of these transcripts, the majority—long, noncoding RNAs (lncRNAs)—are greater than 200 nucleotides in length and are necessary for various roles in the cell.
Patrick A. DeSouza, Xuan Qu, Hao Chen, Bhuvic Patel, Christopher A. Maher, Albert H. Kim   +5 more
openaire   +3 more sources

Long Noncoding RNAs in Plants [PDF]

, 2017
The eukaryotic genomes are pervasively transcribed. In addition to protein-coding RNAs, thousands of long noncoding RNAs (lncRNAs) modulate key molecular and biological processes. Most lncRNAs are found in the nucleus and associate with chromatin, but lncRNAs can function in both nuclear and cytoplasmic compartments.
Hsiao-Lin V, Wang, Julia A, Chekanova
openaire   +2 more sources