Results 91 to 100 of about 19,057 (244)
Loop extrusion drives very different dynamics for Rouse chains in bulk solutions and at interfaces [PDF]
, 2019 The loop extrusion theory predicts that the loops of chromosomes are produced by cohesin molecules that uni-directionally extrude a chromatin fiber. We here use an extension of the Rouse model to predict the chain conformational dynamics driven by the ...
Sakaue, T. +8 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion
Nature CommunicationsCohesin-mediated DNA loop extrusion enables gene regulation by distal enhancers through the establishment of chromosome structure and long-range enhancer-promoter interactions.
Corriene E. Sept +11 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.ABSTRACT Sutures are crucial for tissue approximation and wound healing. Besides their strength limits requirement, they often fail to effectively address complications like infection and pain. Inspired by natural silk's “core‐sheath” structure, our suture features a wet‐spun core of n zinc‐fortified silk fibroin fibers (RSF‐Zn2+) after drawing with ...
Yi Peng +11 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1
eLife, 2019 Cohesin’s association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-
Madhusudhan Srinivasan +8 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A biocompatible sodium alginate‐based hydrogel is developed as a next‐generation submucosal lifting agent intended for EMR and ESD. The optimized formulation exhibits a composition devoid of endotoxins, high viscosity, demonstrates reliable injectability, and ensures prolonged mucosal elevation.
Iram Maqsood +9 more
wiley +1 more source
A Mechanism of Cohesin-Dependent Loop Extrusion Organizes Zygotic Genome Architecture [PDF]
, 2017 SUMMARYFertilization triggers assembly of higher-order chromatin structure from a naïve genome to generate a totipotent embryo. Chromatin loops and domains are detected in mouse zygotes by single-nucleus Hi-C (snHi-C) but not bulk Hi-C.
Sabrina Ladstätter +8 more
core +1 more source
An extrinsic motor directs chromatin loop formation by cohesin
The EMBO JournalThe ring-shaped cohesin complex topologically entraps two DNA molecules to establish sister chromatid cohesion. Cohesin also shapes the interphase chromatin landscape with wide-ranging implications for gene regulation, and cohesin is thought to achieve ...
Thomas M Guérin +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang +4 more
wiley +1 more source