Results 151 to 160 of about 6,762 (168)

Emerging Role of RNA m5C Modification in Cardiovascular Diseases

Journal of Cardiovascular Translational Research, 2022
Epitranscriptomics is the emerging field of research that comprises the study of epigenetics changes in RNAs. Progressing development in the field of epigenetics has helped to manage and comprehend human diseases. RNA methylation regulates all aspects of RNA functions, which are involved in the pathogenesis of human diseases.
Kannan, Balachander, Jayaseelan Vijayashree, Priyadharsini, Anitha, Roy, Arumugam, Paramasivam   +3 more
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m5C mRNAs on the move

Nature Reviews Molecular Cell Biology, 2019
Cytosine methylation (m5C) in mRNAs is important for their transport to distant tissues in plants.
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NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
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YccW is the m5C Methyltransferase Specific for 23S rRNA Nucleotide 1962

Journal of Molecular Biology, 2008
Methylation at the 5-position of cytosine [m(5)C (5-methylcytidine)] occurs at three RNA nucleotides in Escherichia coli. All these modifications are at highly conserved nucleotides in the rRNAs, and each is catalyzed by its own m(5)C methyltransferase enzyme.
Purta, Elzbieta, O'Connor, Michelle, Bujnicki, Janusz M, Douthwaite, Stephen   +3 more
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Target-Specific Profiling of RNA m5C Methylation Level Using Amplicon Sequencing

2021
Mapping the position and quantifying the level of 5-methylcytosine (m5C) as a modification in different types of cellular RNA is an important objective in the field of epitranscriptomics. Bisulfite conversion has long been the gold standard for the detection of m5C in DNA, but it can also be applied to RNA.
Tennille, Sibbritt, Ulrike, Schumann, Andrew, Shafik, Marco, Guarnacci, Susan J, Clark, Thomas, Preiss   +5 more
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m5c-iDeep: 5-Methylcytosine sites identification through deep learning

Methods
5-Methylcytosine (m5c) is a modified cytosine base which is formed as the result of addition of methyl group added at position 5 of carbon. This modification is one of the most common PTM that used to occur in almost all types of RNA. The conventional laboratory methods do not provide quick reliable identification of m5c sites.
Sharaf J, Malebary, Nashwan, Alromema, Muhammad Taseer, Suleman, Maham, Saleem   +3 more
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YebU is a m5C Methyltransferase Specific for 16 S rRNA Nucleotide 1407

Journal of Molecular Biology, 2006
The rRNAs in Escherichia coli contain methylations at 24 nucleotides, which collectively are important for ribosome function. Three of these methylations are m5C modifications located at nucleotides C967 and C1407 in 16S rRNA and at nucleotide C1962 in 23S rRNA.
Andersen, Niels Møller, Douthwaite, Stephen   +1 more
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DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation [PDF]

Molecular Cell
DNA methyltransferase 1 (DNMT1) is an enzyme known for DNA methylation maintenance. Point mutations in its replication focus targeting sequence (RFTS) domain lead to late-onset neurodegeneration, such as autosomal dominant cerebellar ataxia-deafness and narcolepsy (ADCA-DN) disorder.
Jing Wang, Xiaoqian Deng, Tianshen Jian, Shanshan Yin, Linzhi Chen, Laurent Vergnes, Zhehao Li, Huoyuan Liu, Ryan Lee, Sin Yee Lim, Jae Hoon Bahn, Xinshu Xiao, Xianmin Zhu, Ganlu Hu, Karen Reue, Yizhi Liu, Guoping Fan   +16 more
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Left-handed helical conformation of poly[d(A-m5C) · d(G-T)]

Nature, 1983
Poly[d(G-C)] serves as the prototype for the right-to-left (B to Z) transition in he helical sense of DNA, both in solution and inthe crystal form. However, the question remains as to which other synthetic and natural DNAs have the potential to adopt left-handed conformations.
L P, McIntosh, I, Grieger, F, Eckstein, D A, Zarling, J H, van de Sande, T M, Jovin   +5 more
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m5C-Seq: Machine learning-enhanced profiling of RNA 5-methylcytosine modifications

Computers in Biology and Medicine
Epigenetic modifications, particularly RNA methylation and histone alterations, play a crucial role in heredity, development, and disease. Among these, RNA 5-methylcytosine (m5C) is the most prevalent RNA modification in mammalian cells, essential for processes such as ribosome synthesis, translational fidelity, mRNA nuclear export, turnover, and ...
Zeeshan Abbas, Mobeen Ur Rehman, Hilal Tayara, Seung Won Lee, Kil To Chong   +4 more
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