Results 151 to 160 of about 7,626 (175)

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
openaire   +2 more sources

Dynamic landscape and regulation of m5C methylation in human tissues

Science China Life Sciences
5-methylcytosine (m5C) is a prevalent RNA modification that has various impacts on mRNA fate. Here, we generated 30 single-base resolution RNA m5C methylomes and revealed the dynamic nature of m5C of heart, muscle, lung, esophagus, stomach, pancreas, colon, jejunum, and rectum from 7 adult human individuals using RNA-BisSeq.
Ke, An, Ruijuan, Liu, Han, Yang, Luyao, Feng, Xinhan, Zhang, Xuran, Zhang, Mingyang, Hou, Jingyao, Wei, Xiao, Han, Boyang, Shi, Huan, Yao, Xing, Chen, Han, Wang, Xin, Tian   +13 more
openaire   +2 more sources

YebU is a m5C Methyltransferase Specific for 16 S rRNA Nucleotide 1407

Journal of Molecular Biology, 2006
The rRNAs in Escherichia coli contain methylations at 24 nucleotides, which collectively are important for ribosome function. Three of these methylations are m5C modifications located at nucleotides C967 and C1407 in 16S rRNA and at nucleotide C1962 in 23S rRNA.
Andersen, Niels Møller, Douthwaite, Stephen   +1 more
openaire   +3 more sources

RNA methylation and breast cancer: insights into m6A, m7G and m5C

Molecular Biology Reports
Breast cancer remains the most commonly diagnosed cancer in female worldwide, marked by its molecular diversity and complex subtypes. Despite progress in targeted therapies, tumor heterogeneity and treatment resistance continue to present major challenges. Recent studies emphasize the crucial role of RNA modifications in cancer biology, with nearly 200
Yuhan, Dai, Shuhan, Zhao, Huilin, Chen, Wenxin, Yu, Ziyi, Fu, Yangyang, Cui, Hui, Xie   +6 more
openaire   +2 more sources

The Role of RNA m5C Modification in Central Nervous System Diseases

Discovery Medicine
As advances in RNA modification research progress, the significance of 5-methylcytosine (m5C) modification is being increasingly acknowledged. m5C undergoes modification by the methyltransferase NOP2/Sun domain (NSUN) family/DNA methyltransferase (DNMT) family (writer) and is removed by demethylases (eraser), including the ten-eleven translocation (TET)
Peiyan, Wu, Jiaxiang, Gao, Guangming, Lan, Yichao, Wang   +3 more
openaire   +2 more sources

Identification of Human RNA m5C sites using CapsuleNet Architecture

2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2022
Mobeen Ur Rehman, Zeeshan Abbas, Kil To Chong 0001   +2 more
openaire   +2 more sources

m5C Cytosine methyltransferase

2021
openaire   +1 more source

The m6A/m5C/m1A Regulated Gene Signature Predicts the Prognosis and Correlates With the Immune Status of Hepatocellular Carcinoma

Frontiers in Immunology, 2022
Di Ke, Kong-Wu Yang
exaly  

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

RNA Biology, 2021
Xinxia Wang, Xing Liao
exaly  

Vital roles of m5C RNA modification in cancer and immune cell biology

Frontiers in Immunology, 2023
Haihong Zhu, Xinyu Gu
exaly