Results 61 to 70 of about 19,848 (176)

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

De Novo Synthesis of Resveratrol from Sucrose by Metabolically Engineered Yarrowia lipolytica

Biomolecules
Resveratrol, a phenylpropanoid compound, exhibits diverse pharmacological properties, making it a valuable candidate for health and disease management.
Gehad G. Ibrahim, Madhavi Perera, Saadiah A. Abdulmalek, Jinyong Yan, Yunjun Yan   +4 more
doaj   +1 more source

Overlooked components of lipid metabolism: Odd‐chain polyunsaturated fatty acids in photosynthetic microorganisms

Journal of Phycology, EarlyView.
Abstract This mini‐review examines odd‐carbon polyunsaturated fatty acids (odd‐PUFAs), a rare but biologically significant group of fatty acids in photosynthetic microorganisms. Odd‐PUFAs are straight‐chain fatty acids containing an odd number of carbon atoms and two or more methylene‐interrupted double bonds. They typically account for less than 1% of
Linda Nedbalová, Milada Vítová, Tomáš Řezanka   +2 more
wiley   +1 more source

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form

BBA Advances
Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
doaj   +1 more source

Paving the Way for Plant‐Based Bioproduction of (Z)‐13‐Octadecenoic Moth Pheromone Compounds

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sex pheromones are eco‐friendly agents to control pest insects. Yet, the cost of synthetic pheromone production has restricted their use essentially to high value crops. Plant‐based bioproduction of pheromone compounds offers a promising and sustainable alternative, opening up for the deployment of pheromone‐mediated pest control also in row ...
Mengyu Liu, Huijing Li, Huanhuan Jin, Yue Xiao, Panpan He, Chang Tan, Hong‐Lei Wang, Jean‐Marc Lassance, Christer Löfstedt, Bao‐Jian Ding   +9 more
wiley   +1 more source

Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. [PDF]

PLoS Pathogens, 2013
Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To
Emre Koyuncu, John G Purdy, Joshua D Rabinowitz, Thomas Shenk   +3 more
doaj   +1 more source

SbWRKY62 Coordinates With SbERF096 to Activate Pterostilbene Biosynthesis and Targets a Xylanase Inhibitor Protein for Anthracnose Resistance in Sorghum

Plant, Cell &Environment, EarlyView.
ABSTRACT Sorghum anthracnose caused by Colletotrichum sublineola (C. sublineola) is a destructive disease leading to severe crop damages. Pterostilbene is a phytoalexin that contributes to defence responses in sorghum, but the transcriptional regulation of its biosynthesis remained poorly understood.
Yajing Li, Bofu Deng, Yiming Gan, Nan Lin, Dan Zhou, Clive Lo   +5 more
wiley   +1 more source

Evidence of two catalytically active carnitine medium/long chain acyltransferases in rat liver peroxisomes

Journal of Lipid Research, 1996
Peroxisomal matrix proteins were extracted from the highly purified peroxisomes with sodium pyrophosphate, and the membranes were sedimented by high speed centrifugation.
H Singh, K Beckman, A Poulos
doaj   +1 more source

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source