Results 51 to 60 of about 19,848 (176)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB

Frontiers in Microbiology, 2021
Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Pan Wang, Pan Wang, Pan Wang, Xin Wang, Xin Wang, Xin Wang, Ying Yin, Ying Yin, Ying Yin, Mingliang He, Mingliang He, Mingliang He, Wei Tan, Wei Tan, Wei Tan, Wenting Gao, Wenting Gao, Wenting Gao, Jianping Wen, Jianping Wen, Jianping Wen   +20 more
doaj   +1 more source

Reconsidering the impact of saturated fat intake on metabolic health: A critical review of evidence and controversies

Food Biomacromolecules, EarlyView.
Abstract Saturated fats (SFAs) play a complex role in health; therefore, their intake has been a topic of debate in the field of nutrition science. Therefore, this article emphasizes the importance of a balanced diet rather than SFA, considering genetic and metabolic differences, and advocates for the reconsideration of dietary guidelines based on the ...
Akash Kumar, Dipak S. Thorat, Sangeeta Yadav, Pooja Yadav, Jhilam Pramanik, Yogesh V. Ushir, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
wiley   +1 more source

Malonyl CoA: A promising target for the treatment of cardiac disease [PDF]

IUBMB Life, 2014
AbstractAlterations in cardiac energy metabolism are an important contributor to the high incidence and severity of heart disease in the world. These alterations can include an impairment of the production of ATP necessary to meet the high energy demands of the heart, as well as adverse switches in energy substrate preference by the heart.
Natasha, Fillmore, Gary D, Lopaschuk
openaire   +2 more sources

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.

PLoS Pathogens, 2013
The biosynthesis of membrane lipids is an essential pathway for virtually all bacteria. Despite its potential importance for the development of novel antibiotics, little is known about the underlying signaling mechanisms that allow bacteria to control ...
Daniela Albanesi, Georgina Reh, Marcelo E Guerin, Francis Schaeffer, Michel Debarbouille, Alejandro Buschiazzo, Gustavo E Schujman, Diego de Mendoza, Pedro M Alzari   +8 more
doaj   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion

Molecular Metabolism, 2016
Objective: Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites.
Mahmoud El Azzouny, Melissa J. Longacre, Israr-ul H. Ansari, Robert T. Kennedy, Charles F. Burant, Michael J. MacDonald   +5 more
doaj   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, EarlyView.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin

Nature Communications, 2022
Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p-coumaroyl-CoA and three malonyl-CoA molecules as substrates. Here, the authors report a fungal non-ribosomal peptide
Hongjiao Zhang, Zixin Li, Shuang Zhou, Shu-Ming Li, Huomiao Ran, Zili Song, Tao Yu, Wen-Bing Yin   +7 more
doaj   +1 more source