Results 31 to 40 of about 19,848 (176)
Dissection of malonyl-coenzyme A reductase of Chloroflexus aurantiacus results in enzyme activity improvement. [PDF]
PLoS ONE, 2013 The formation of fusion protein in biosynthetic pathways usually improves metabolic efficiency either channeling intermediates and/or colocalizing enzymes. In the metabolic engineering of biochemical pathways, generating unnatural protein fusions between
Changshui Liu +4 more
doaj +1 more source
Properties of Malonyl‐CoA Decarboxylase and its Relation with Malonyl‐CoA Incorporation into Fatty Acids by Rat Liver Mitochondria [PDF]
European Journal of Biochemistry, 1971 1 Malonyl-CoA decarboxylase in rat liver, heart, kidney and brain is mainly a mitochondrial enzyme associated with the matrix space. 2 The Michaelis constant for this enzyme, in rat liver mitochondria, has been calculated as 42 μM. 3 N-Ethylmaleimide, p-chloromercuribenzoate and palmityl-CoA, but not arsenite, inhibit malonyl-CoA decarboxylase.
C, Landriscina +2 more
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Mechanism of activation of bovine kidney pyruvate dehydrogenase a kinase by malonyl‐CoA and enzyme‐catalyzed decarboxylation of malonyl‐CoA [PDF]
European Journal of Biochemistry, 1985 The activity of the pyruvate dhydrogenase kinase, which phosphorylates and therby inactivates the pyruvate dehydrogenase complex, was stimulated by malonyl‐CoA. Treatment with [2‐14C]malonyl‐CoA resulted in acylation of sites in the complex. Both acylation and activation of kinase activity increased in a time‐dependent manner with a parallel increase ...
M, Rahmatullah +3 more
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Microbiology Spectrum, 2022 The Fus3-MAP kinase module is a conserved phosphorylation signal system in eukaryotes that responds to environmental stress and transduction of external signals from the outer membrane to the nucleus. Aspergillus flavus can produce aflatoxins (AF), which
Longxue Ma +5 more
doaj +1 more source
A Genetically Encoded Metabolite Sensor for Malonyl-CoA
Chemistry & Biology, 2012 Malonyl-CoA is the rate-determining metabolite for long chain de novo fatty acid synthesis and allosterically inhibits the rate-setting step in long chain fatty acid β-oxidation. We developed a cell-based genetically encoded biosensor based on the malonyl-CoA responsive Bacillus subtilis transcriptional repressor, FapR, for living mammalian cells. Here,
Ellis, Jessica M. +1 more
openaire +2 more sources
Angewandte Chemie, EarlyView.A stereoselective functionalization method of cyclic imines under mild organocatalytic conditions was developed. Bifunctional cinchona alkaloid catalysts combined with carefully optimized reaction conditions to suppress background reactivity enabled highly enantio‐ and diastereoselective addition reactions of malonates to cyclic imines.
Frederic Kölblin, Helma Wennemers
wiley +2 more sources
De novo synthesis and elongation of fatty acids by subcellular fractions of monkey aorta
Journal of Lipid Research, 1968 Subcellular fractions of aorta of squirrel monkey (Saimiri sciureus) were examined for their ability to synthesize and elongate fatty acids. High-speed supernate (HSS) incorporated substantial quantities of malonyl CoA into fatty acids while acetyl CoA ...
Charles F. Howard, Jr.
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Production of 3-hydroxypropionic acid (3-HP) in Pichia pastoris (syn. Komagataella phaffii) via the malonyl-CoA pathway has been recently demonstrated using glycerol as a carbon source, but the reported metrics were not commercially relevant.
Albert Fina +3 more
doaj +1 more source
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
eLife, 2019 Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored.
Marta Palomo-Guerrero +12 more
doaj +1 more source
Ralstonia solanacearum RSp0194 Encodes a Novel 3-Keto-Acyl Carrier Protein Synthase III. [PDF]
PLoS ONE, 2015 Fatty acid synthesis (FAS), a primary metabolic pathway, is essential for survival of bacteria. Ralstonia solanacearum, a β-proteobacteria member, causes a bacterial wilt affecting more than 200 plant species, including many economically important plants.
Ya-Hui Mao +4 more
doaj +1 more source