Results 11 to 20 of about 19,848 (176)
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism [PDF]
Advances in Biological Regulation, 2019 Malonyl-CoA is a central metabolite in fatty acid biochemistry. It is the rate-determining intermediate in fatty acid synthesis but is also an allosteric inhibitor of the rate-setting step in mitochondrial long-chain fatty acid oxidation. While these canonical cytoplasmic roles of malonyl-CoA have been well described, malonyl-CoA can also be generated ...
Caitlyn Bowman, Michael Wolfgang
exaly +5 more sources
Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin [PDF]
Microbial Cell Factories, 2019 Background In the last years, different biotechnologically relevant microorganisms have been engineered for the synthesis of plant polyphenols such as flavonoids and stilbenes. However, low intracellular availability of malonyl-CoA as essential precursor
Lars Milke +3 more
doaj +2 more sources
Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis [PDF]
Journal of Lipid Research, 2019 Deuterated water (2H2O) is widely used for measuring de novo lipogenesis (DNL). 2H is incorporated into fatty acids via exchange between body water and the hydrogens of acetyl-CoA, malonyl-CoA, and NADPH.
Getachew Debas Belew +8 more
doaj +2 more sources
Malonyl-CoA Decarboxylase: A Spotlight on Brain Aspects
Brain SciencesMalonyl-CoA decarboxylase (MCD) is an enzyme that controls malonyl-CoA levels and regulates fatty acid synthesis and oxidation. Although its physiological relevance in peripheral tissues is well known, the role of MCD in the central nervous system ...
Monique Fonseca-Teixeira +5 more
doaj +4 more sources
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA [PDF]
ACS Bio & Med Chem AuDanielle Schmitt
exaly +2 more sources
mSystems, 2022 Malonyl-coenzyme A (malonyl-CoA) is an important precursor for producing various chemicals, but its low availability limits the synthesis of downstream products in Saccharomyces cerevisiae.
Chenxi Qiu +8 more
doaj +1 more source
Dynamic-tuning yeast storage carbohydrate improves the production of acetyl-CoA-derived chemicals
iScience, 2023 Summary: Acetyl-coenzyme A (Acetyl-CoA) and malonyl-coenzyme A (malonyl-CoA) are important precursors for producing various chemicals, and their availability affects the production of their downstream chemicals.
Chenxi Qiu +4 more
doaj +1 more source
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
Cell Reports, 2023 Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme +18 more
doaj +1 more source
Malonyl-CoA metabolism in cardiac myocytes [PDF]
Biochemical Journal, 2000 (1) Malonyl-CoA is thought to play a signalling role in fuel-selection in cardiac muscle, but the rate at which the concentration of this potential signal can be changed has not previously been investigated. (2) Rapid changes in cellular malonyl-CoA could be observed when rat cardiac myocytes were incubated in glucose-free medium followed by re ...
C, Hamilton, E D, Saggerson
openaire +2 more sources
Frontiers in Microbiology, 2022 3-Hydroxypropionic acid (3-HP) is a promising high value-added chemical. Acetyl-CoA carboxylase (Acc) is a vital rate-limiting step in 3-HP biosynthesis through the malonyl-CoA pathway.
Sumeng Wang +5 more
doaj +1 more source