Results 41 to 50 of about 19,848 (176)

A Role for Hypothalamic Malonyl-CoA in the Control of Food Intake [PDF]

Journal of Biological Chemistry, 2005
The cellular level of malonyl-CoA, an intermediate in fatty acid biosynthesis, depends on its rate of synthesis catalyzed by acetyl-CoA carboxylase relative to its rate of utilization and degradation catalyzed by fatty acid synthase and malonyl-CoA decarboxylase, respectively.
Zhiyuan, Hu, Yun, Dai, Marc, Prentki, Shigeru, Chohnan, M Daniel, Lane   +4 more
openaire   +2 more sources

Improving Production of Malonyl Coenzyme A-Derived Metabolites by Abolishing Snf1-Dependent Regulation of Acc1

mBio, 2014
Acetyl coenzyme A (acetyl-CoA) carboxylase (ACCase) plays a central role in carbon metabolism and has been the site of action for the development of therapeutics or herbicides, as its product, malonyl-CoA, is a precursor for production of fatty acids and
Shuobo Shi, Yun Chen, Verena Siewers, Jens Nielsen   +3 more
doaj   +1 more source

Enhancing 3-hydroxypropionic acid production in combination with sugar supply engineering by cell surface-display and metabolic engineering of Schizosaccharomyces pombe

Microbial Cell Factories, 2018
Background Economical production of value-added chemicals from renewable biomass is a promising path to sustainability. 3-Hydroxypropionic acid (3-HP) is an important chemical for building a bio-sustainable society.
Seiya Takayama, Aiko Ozaki, Rie Konishi, Chisako Otomo, Mayumi Kishida, Yuuki Hirata, Takuya Matsumoto, Tsutomu Tanaka, Akihiko Kondo   +8 more
doaj   +1 more source

Regulation of Malonyl-CoA Concentration and Turnover in the Normal Heart [PDF]

Journal of Biological Chemistry, 2004
The goal of this study was to test the relationship between malonyl-CoA concentration and its turnover measured in isolated rat hearts perfused with NaH(13)CO(3). This turnover is a direct measurement of the flux of acetyl-CoA carboxylation in the intact heart. It also reflects the rate of malonyl-CoA decarboxylation, i.e.
Aneta E, Reszko, Takhar, Kasumov, France, David, Katherine R, Thomas, Kathryn A, Jobbins, Jie-Fei, Cheng, Gary D, Lopaschuk, Jason R B, Dyck, Mireya, Diaz, Christine, Des Rosiers, William C, Stanley, Henri, Brunengraber   +11 more
openaire   +2 more sources

Regulation of hypothalamic malonyl-CoA by central glucose and leptin [PDF]

Proceedings of the National Academy of Sciences, 2007
Hypothalamic malonyl-CoA has been shown to function in global energy homeostasis by modulating food intake and energy expenditure. Little is known, however, about the regulation of malonyl-CoA concentration in the central nervous system. To address this issue we investigated the response of putative intermediates in the malonyl-CoA
Michael J, Wolfgang, Seung Hun, Cha, Aniket, Sidhaye, Shigeru, Chohnan, Gary, Cline, Gerald I, Shulman, M Daniel, Lane   +6 more
openaire   +2 more sources

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

eLife, 2023
Malonyl-CoA-acyl carrier protein transacylase (MCAT) is an enzyme involved in mitochondrial fatty acid synthesis (mtFAS) and catalyzes the transfer of the malonyl moiety of malonyl-CoA to the mitochondrial acyl carrier protein (ACP).
Bryn D Webb, Sara M Nowinski, Ashley Solmonson, Jaya Ganesh, Richard J Rodenburg, Joao Leandro, Anthony Evans, Hieu S Vu, Thomas P Naidich, Bruce D Gelb, Ralph J DeBerardinis, Jared Rutter, Sander M Houten   +12 more
doaj   +1 more source

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie International Edition, EarlyView.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +1 more source

A sense of balance: Experimental investigation and modeling of a malonyl-CoA sensor in Escherichia coli

Frontiers in Bioengineering and Biotechnology, 2015
Production of value-added chemicals in microorganisms is regarded as a viable alternative to chemical synthesis. In the past decade, several engineered pathways producing such chemicals, including plant secondary metabolites in microorganisms have been ...
Tamas eFeher, Vincent eLibis, Pablo eCarbonell, Pablo eCarbonell, Jean-Loup eFaulon   +4 more
doaj   +1 more source

NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression

EMBO Reports, 2023
Nonalcoholic fatty liver disease (NAFLD) is mainly characterized by excessive fat accumulation in the liver, and it is associated with liver-related complications and adverse systemic diseases.
Shaofang Xie, Lei Yuan, Yue Sui, Shan Feng, Hengle Li, Xu Li   +5 more
doaj   +1 more source

Effects of prolonged ingestion of glucose or ethanol on fatty acid synthesis by mitochondria and cell sap of rat liver and adipose tissue

Journal of Lipid Research, 1966
Effects of prolonged ingestion of glucose and ethanol on the rate of fatty acid synthesis by liver and adipose tissue have been investigated in male rats.
Nicholas M. Alexander, Robert Scheig, Gerald Klatskin   +2 more
doaj   +1 more source