Results 21 to 30 of about 19,848 (176)
Acetyl-CoA Carboxylases and Diseases
Frontiers in Oncology, 2022 Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs.
Yu Wang +7 more
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MCD Encodes Peroxisomal and Cytoplasmic Forms of Malonyl-CoA Decarboxylase and Is Mutated in Malonyl-CoA Decarboxylase Deficiency [PDF]
Journal of Biological Chemistry, 1999 Malonyl-CoA decarboxylase (MCD) catalyzes the proton-consuming conversion of malonyl-CoA to acetyl-CoA and CO(2). Although defects in MCD activity are associated with malonyl-CoA decarboxylase deficiency, a lethal disorder characterized by cardiomyopathy and developmental delay, the metabolic role of this enzyme in mammals is unknown.
Sacksteder, K. A. +4 more
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The Molecular Basis of Malonyl-CoA Decarboxylase Deficiency [PDF]
The American Journal of Human Genetics, 1999 We characterized a 2.1-kb human cDNA with a 1362-bp (454-amino acid) open reading frame showing 70.3% amino acid identity to goose malonyl-CoA decarboxylase (MCD). We have identified two different homozygous mutations in human MCD (hMCD) by using RT-PCR analysis of fibroblast RNA from two previously reported consanguineous Scottish patients with MCD ...
FitzPatrick, David R. +4 more
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Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase [PDF]
Biochemical Journal, 1992 Although the malonyl-CoA sensitivity of peroxisomal carnitine octanoyltransferase (COT) is reportedly lost on solubilization, we show that malonyl-CoA does inhibit the purified enzyme. Assay conditions such as buffer composition, pH, acyl-CoA substrate and the presence or absence of BSA can affect the observed inhibition. When assayed in the absence of
N N, A'Bháird, R R, Ramsay
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Hypothalamic malonyl-CoA as a mediator of feeding behavior [PDF]
Proceedings of the National Academy of Sciences, 2003 Previous studies showed that i.p. administration of C75, a potent inhibitor of fatty acid synthase (FAS), blocked fasting-induced up-regulation of orexigenic neuropeptides and down-regulation of anorexigenic neuropeptides in the hypothalami of mice. As a result, food intake and body weight were drastically reduced.
Zhiyuan, Hu +3 more
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Histone malonylation is regulated by SIRT5 and KAT2A
iScience, 2023 Summary: The posttranslational modification lysine malonylation is found in many proteins, including histones. However, it remains unclear whether histone malonylation is regulated or functionally relevant. Here, we report that availability of malonyl-co-
Ran Zhang +10 more
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The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis [PDF]
Journal of Biological Chemistry, 2006 Energy balance is monitored by hypothalamic neurons that respond to peripheral hormonal and afferent neural signals that sense energy status. Recent physiologic, pharmacologic, and genetic evidence has implicated malonyl-CoA, an intermediate in fatty acid synthesis, as a regulatory component of this energy-sensing system.
Michael J, Wolfgang, M Daniel, Lane
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Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics
eLife, 2021 Volatile anesthetics (VAs) are widely used in medicine, but the mechanisms underlying their effects remain ill-defined. Though routine anesthesia is safe in healthy individuals, instances of sensitivity are well documented, and there has been significant
Julia Stokes +13 more
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The return of malonyl-CoA to the brain: Cognition and other stories
Progress in Lipid Research, 2021 Nutrients, hormones and the energy sensor AMP-activated protein kinase (AMPK) tightly regulate the intracellular levels of the metabolic intermediary malonyl-CoA, which is a precursor of fatty acid synthesis and a negative regulator of fatty acid oxidation.
Fadó Andrés, Rut +2 more
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Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase
Journal of Lipid Research, 1999 Malonyl coenzyme A (CoA) decarboxylase (E.C.4. 1.1.9) catalyzes the conversion of malonyl CoA to acetyl CoA. The metabolic role of malonyl CoA decarboxylase has not been fully defined, but deficiency of the enzyme has been associated with mild mental ...
Jimin Gao +4 more
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