Results 1 to 10 of about 19,208 (245)

MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression

npj Precision Oncology, 2023
MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the pathogenesis of melanoma.
Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh, Andrew Fong, Lin Li, Shira Ronen, Shuyang Chen, Pauline Funchain, Ying Ni, Joshua Arbesman   +9 more
doaj   +2 more sources

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

Journal of Neuroinflammation, 2021
Background Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammatory and neuroprotective effects in ...
Shufeng Yu, Desislava Met Doycheva, Marcin Gamdzyk, Yijun Yang, Cameron Lenahan, Gaigai Li, Dujuan Li, Lifei Lian, Jiping Tang, Jun Lu, John H. Zhang   +10 more
doaj   +2 more sources

Effect of polymorphisms in the 5’-flanking sequence of MC1R on feather color in Taihang chickens

Poultry Science, 2022
: MC1R plays an important role in the regulation of the formation, transfer, and deposition of melanin in animals and is important for determining coat color.
Yekai Fan, Xianwen Wu, Yamin Li, Haiyin Han, Yifan Zhang, Junqi Yang, Yufang Liu   +6 more
doaj   +2 more sources

MC1R Is a Prognostic Marker and Its Expression Is Correlated with MSI in Colorectal Cancer

Current Issues in Molecular Biology, 2021
Melanocortin 1 receptor (MC1R) is thought to be a marker of poor prognosis and a potential target for the treatment of melanoma. Studies have found that MC1R promotes several tumor behaviors, including cell proliferation and differentiation, pigment ...
Lixiong Peng, Jiang Chang, Xilin Liu, Shiying Lu, Honglin Ren, Xiaoshi Zhou, Zengshan Liu, Pan Hu   +7 more
doaj   +2 more sources

Functional divergence of the pigmentation gene melanocortin-1 receptor (MC1R) in six endemic Macaca species on Sulawesi Island

Scientific Reports, 2022
Coat color is often highly variable within and between animal taxa. Among hundreds of pigmentation-related genes, melanocortin-1 receptor (MC1R) plays key roles in regulating the synthesis of the dark eumelanin and the red–yellow pheomelanin.
Xiaochan Yan, Yohey Terai, Kanthi Arum Widayati, Akihiro Itoigawa, Laurentia Henrieta Permita Sari Purba, Fahri Fahri, Bambang Suryobroto, Hiroo Imai   +7 more
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The protective role of MC1R in chromosome stability and centromeric integrity in melanocytes

Cell Death Discovery, 2021
Variants in the melanocortin-1 receptor (MC1R) gene, encoding a trimeric G-protein-coupled receptor and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fair skin, freckling, and skin sensitivity ...
Xin Li, Weiwei Mao, Jie Chen, Colin R. Goding, Rutao Cui, Zhi-Xiang Xu, Xiao Miao   +6 more
doaj   +2 more sources

Specific mutations in the genes of MC1R and TYR have an important influence on the determination of pheomelanin pigmentation in Korean native chickens

Journal of Advanced Veterinary and Animal Research, 2021
Objective: The TYR (Tyrosinase) and MC1R (Melanocortin 1 receptor) genes are recognized as important genes involved in plumage pigmentation in Korean native chickens. Specifically, most color patterns in chicken result from differential expression of the
In Sik Nam, Min Gee Oh, Myoung Soo Nam, Woan Sub Kim   +3 more
doaj   +2 more sources

Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses.
Anni Suominen, Aino Suni, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Minying Cai, Eriika Savontaus, Virpi Talman, Risto Kerkelä, Petteri Rinne   +9 more
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TET2 orchestrates YAP signaling to potentiate targetable vulnerability in hepatocellular carcinoma [PDF]

Cell Death and Disease
Hepatocellular carcinoma (HCC) is a leading cause of global cancer-associated mortality. Although various therapies have substantially ameliorated clinical outcome, patients invariably suffer from cancer relapse, highlighting the need for more optimized ...
Jing He, Mingen Lin, Fei Teng, Xue Sun, Ziyin Tian, Jiaxi Li, Yan Ma, Yue Dai, Yi Gao, Hongchen Li, Tongguan Tian, Kai Xu, Xinxing Li, Lei Lv, Yanping Xu   +14 more
doaj   +2 more sources

Melanocortin-1 receptor expression as a predictive factor for postoperative outcomes in melanoma patients: a retrospective study [PDF]

Frontiers in Immunology
Background and objectiveThis study aims to explore the relationship between melanocortin-1 receptor (MC1R) expression levels and clinical pathological parameters of melanoma, as well as its potential as a prognostic biomarker.MethodsThis retrospective ...
Tian Xiang, Tian Xiang, Haiying Li, Xiaowei Wang, Danke Su   +4 more
doaj   +2 more sources