Results 11 to 20 of about 19,208 (245)

Single‐cell profiling of MC1R‐inhibited melanocytes

Pigment Cell & Melanoma Research, 2023
The human red hair color (RHC) trait is caused by increased pheomelanin (red‐yellow) and reduced eumelanin (black‐brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function.
H. M. Berns, D. Watkins-Chow, Sizhu Lu, Pakavarin Louphrasitthiphol, Tongwu Zhang, Kevin Brown, Pedro Moura-Alves, Colin R. Goding, William J. Pavan   +8 more
semanticscholar   +4 more sources

Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects

International Journal of Molecular Sciences, 2023
Melanocortins play crucial roles in regulating the stress response, inflammation, and skin pigmentation. In this review, we focus on the melanocortin 1 receptor (MC1R), a G protein-coupled receptor primarily known for regulating skin pigmentation and ...
Yoonwoo Mun, Woohyun Kim, Dongyun Shin
semanticscholar   +3 more sources

Pig Coat Color Manipulation by MC1R Gene Editing

International Journal of Molecular Sciences, 2022
Black coat color in pigs is determined by the dominant E allele at the MC1R locus. Through comparing MC1R gene sequences between recessive e and dominant ED1 alleles, we identified four missense mutations that could affect MC1R protein function for ...
Haiwen Zhong, Jian Zhang, Cheng Tan, Junsong Shi, Jie Yang, Gengyuan Cai, Zhenfang Wu, Huaqiang Yang   +7 more
semanticscholar   +3 more sources

Palmitoylation-dependent activation of MC1R prevents melanomagenesis [PDF]

Nature, 2017
The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signalling and melanin production and ...
Shuyang Chen, Bo Zhu, Chengqian Yin, W. Liu, Changpeng Han, Baoen Chen, Tongzheng Liu, Xin Li, Xiang Chen, Chunying Li, Li-min Hu, Jun Zhou, Zhi-xiang Xu, Xiumei Gao, Xu Wu, C. Goding, Rutao Cui   +16 more
semanticscholar   +6 more sources

AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis.

Cancer Research, 2023
Inherited genetic variations in the melanocortin-1 receptor (MC1R) responsible for human red hair color (RHC-variants) are associated with impaired DNA damage repair and increased melanoma risk.
Yu Sun, Xin Li, Chengqian Yin, Judy Zhang, Ershang Liang, Xianfang Wu, Y. Ni, J. Arbesman, C. Goding, Shuyang Chen   +9 more
semanticscholar   +4 more sources

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads [PDF]

Nature Communications, 2019
Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by
Shuyang Chen, Changpeng Han, X. Miao, Xin Li, Chengqian Yin, Jun Zou, Min Liu, Shanshan Li, L. Stawski, Bo Zhu, Qiong Shi, Zhi-xiang Xu, Chunying Li, C. Goding, Jun Zhou, Rutao Cui   +15 more
semanticscholar   +5 more sources

Germline MC1R status influences somatic mutation burden in melanoma [PDF]

Nature Communications, 2016
The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene.
A Ozola, A Yates, C Wilks, CM Olsen, D Mitra, DL Duffy, DT Bishop, E Healy, E Hodis, E Pasquali, ED Pleasance, H Ikehata, I Adzhubei, J Cao, JA Newton-Bishop, JC García-Borrón, JE Hauser, JJ Latimer, JR Davies, JS Más, K Cibulskis, K Jagirdar, KA Beaumont, KA Beaumont, L Denat, LB Alexandrov, M Krauthammer, M Krauthammer, MF Berger, P Shriber, P Valverde, PB Cassidy, PC Ng, PF Williams, RA Sturm, S Raimondi, S van Buuren, SA Forbes, SG Jarrett, SG Jarrett, T Dwyer, TH Nasti, V Swope, YW Teh, Z Zhang, ZA Abdel-Malek   +45 more
core   +6 more sources

MC1R Functions, Expression, and Implications for Targeted Therapy.

Journal of Investigative Dermatology, 2021
The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition. Beyond its role in pigmentation, MC1R is increasingly recognized as promoting UV-induced DNA damage repair.
S. Guida, G. Guida, C. Goding
semanticscholar   +4 more sources

Comparative FISH-Mapping of MC1R, ASIP, and TYRP1 in New and Old World Camelids and Association Analysis With Coat Color Phenotypes in the Dromedary (Camelus dromedarius)

Frontiers in Genetics, 2019
Melanocortin 1 receptor (MC1R), the agouti signaling protein (ASIP), and tyrosinase related protein 1 (TYRP1) are among the major regulators of pigmentation in mammals.
Fahad Alshanbari, Caitlin Castaneda, Rytis Juras, Andrew Hillhouse, Mayra N. Mendoza, Gustavo A. Gutiérrez, Federico Abel Ponce de León, Terje Raudsepp   +7 more
doaj   +2 more sources

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Molecular Neurodegeneration, 2022
Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD).
Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen   +10 more
doaj   +1 more source