Results 21 to 30 of about 19,208 (245)

Identification of key genes and evaluation of immune cell infiltration in vitiligo

Mathematical Biosciences and Engineering, 2021
Background: To improve the understanding of the molecular mechanism of vitiligo is necessary to predict and formulate new targeted gene therapy strategies.
Xiangyue Zhang, Wen Hu, Zixian Lei , Hongjuan Wang, Xiaojing Kang   +4 more
doaj   +1 more source

EGCG, GCG, TFDG, or TSA Inhibiting Melanin Synthesis by Downregulating MC1R Expression

International Journal of Molecular Sciences, 2023
Without affecting cell viability, epigallocatechin gallate (EGCG), gallocatechin gallate (GCG), theaflavine-3,3′-digallate (TFDG), or theasinensin A (TSA) have been found to effectively reduce intracellular melanin content and tyrosinase (TYR) activity ...
Wei Wang, Taimei Di, Weiwei Wang, Heyuan Jiang   +3 more
semanticscholar   +1 more source

The MC1R Gene and Youthful Looks [PDF]

Current Biology, 2016
Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital for
Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., Heemst, D. van, Murray, P.G., Wollstein, A., Craen, A.J.M. de, Uh, H.W., Zeng, C.Q., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., Gunn, D.A.   +19 more
openaire   +5 more sources

Open AccessLack of association between coat color abnormalities in Bali cattle (Bos javanicus) and the coding regions of the MC1R and KIT genes

Veterinary World, 2023
Background and Aim: Coat color variations in cattle are known to be influenced by the melanocortin 1 receptor (MC1R) and receptor tyrosine kinase (KIT) genes.
J. Jakaria, K. Kholijah, S. Darwati, Qonita Rahman, Winni Liani Daulay, I. Suhendro, I. Londra, M. F. Ulum, R. R. Noor   +8 more
semanticscholar   +1 more source

Evidence for Variable Selective Pressures at MC1R [PDF]

The American Journal of Human Genetics, 2000
It is widely assumed that genes that influence variation in skin and hair pigmentation are under selection. To date, the melanocortin 1 receptor (MC1R) is the only gene identified that explains substantial phenotypic variance in human pigmentation. Here we investigate MC1R polymorphism in several populations, for evidence of selection. We conclude that
Harding, Rosalind M., Healy, Eugene, Ray, Amanda J., Ellis, Nichola S., Flanagan, Niamh, Todd, Carol, Dixon, Craig, Sajantila, Antti, Jackson, Ian J., Birch-Machin, Mark A., Rees, Jonathan L.   +10 more
openaire   +4 more sources

Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease

Journal of Neuroimmune Pharmacology, 2023
Background Melanocortin 1 receptor ( MC1R ) is a key pigmentation gene, and loss-of-function of MC1R variants that produce red hair may be associated with Parkinson’s disease (PD).
Pranay Srivastava, Shuhei Nishiyama, Fang Zhou, Sonia H Lin, Akriti Srivastava, Chienwen Su, Yuehang Xu, Weiyi Peng, Michael Levy, M. Schwarzschild, Xiqun Chen   +10 more
semanticscholar   +1 more source

The role of melanocortin 1 receptor on melanogenesis pathway in skin color differentiation of red tilapia

Aquaculture Reports, 2022
The skin color differentiation and variation are the main problems limiting the development of red tilapia commercial culture. The specific function and regulation mechanism of mc1r gene in fish pigmentation are still poorly understood. In this study, we
Lan-mei Wang, Bing-jie Jiang, Wen-bin Zhu, Jian-jun Fu, Ming-kun Luo, Wei Liu, Zai-jie Dong   +6 more
doaj   +1 more source

Melanocortin 1 receptor (MC1R) expression as a marker of progression in melanoma

Research Square, 2023
Melanocortin-1 receptor (MC1R) plays a critical role in human pigmentation and DNA repair mechanisms. MC1R-targeting agents are being investigated in clinical trials in melanoma patients, yet large studies investigating the rate and degree of MC1R ...
David G. Su, Dijana Djureinovic, D. Schoenfeld, Bernadette Marquez-Nostra, K. Olino, Lucia Jilaveanu, Harriet M. Kluger   +6 more
semanticscholar   +1 more source

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model

Oxidative Medicine and Cellular Longevity, 2022
Neuronal apoptosis induced by oxidative stress plays an important role in the pathogenesis and progression of hypoxic‐ischemic encephalopathy (HIE). Previous studies reported that activation of melanocortin‐1 receptor (MC1R) exerts antioxidative stress ...
Shufeng Yu, Desislava Doycheva, M. Gamdzyk, Yuan-yuan Gao, Yong Guo, Zachary D. Travis, Jiping Tang, Wen-xiong Chen, John H. Zhang   +8 more
semanticscholar   +1 more source

A KIT Variant Associated with Increased White Spotting Epistatic to MC1R Genotype in Horses (Equus caballus)

Animals, 2022
Simple Summary Although over 40 genetic variants are known to influence white spotting and markings on the horse, many still have unknown genetic causes. Furthermore, some seem to be influenced by pigmentation (base coat color) genes. We investigated two
L. Patterson Rosa, K. Martin, M. Vierra, E. Lundquist, G. Foster, S. Brooks, C. Lafayette   +6 more
semanticscholar   +1 more source