Results 51 to 60 of about 19,208 (245)

Discriminant analysis of colour measurements reveals allele dosage effect of ASIP/MC1R in bay horses

Czech Journal of Animal Science, 2018
Considering the variability of bay coat colour, we aimed to investigate the association of different shades of bay with ASIP and MC1R genotype combinations and we studied the discrimination between the bay and black coat colour.
Thomas Druml, Gertrud Grilz-Seger, Michaela Horna, Gottfried Brem   +3 more
doaj   +1 more source

Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity

Nature Communications, 2023
Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report that loss of melanocortin-1 receptor (MC1R) in ...
Yazhong Cui, Yang Miao, Longzhi Cao, Lifang Guo, Yue Cui, Chuanzhe Yan, Zhi Zeng, Mo Xu, Ting Han   +8 more
doaj   +1 more source

Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour

Scientific Reports, 2021
Zhoushan cattle are an endangered cattle breed in the Zhoushan islands in China. Since Zhoushan cattle have been bred in isolation, they show unique characteristics, such as dark black coat colour. However, no studies have been conducted on the genome of
Lihua Jiang, Tetsuo Kon, Chunyan Chen, Ryota Ichikawa, Qiyuan Zheng, Liyi Pei, Ikuyo Takemura, Lauden Hagai Nsobi, Hiromasa Tabata, Hao Pan, Y. Omori, A. Ogura   +11 more
semanticscholar   +1 more source

MC1R signaling. Intracellular partners and pathophysiological implications

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017
The melanocortin-1 receptor (MC1R) preferentially expressed in melanocytes is best known as a key regulator of the synthesis of epidermal melanin pigments. Its paracrine stimulation by keratinocyte-derived melanocortins also activates DNA repair pathways and antioxidant defenses to build a complex, multifaceted photoprotective response.
Cecilia, Herraiz, Jose C, Garcia-Borron, Celia, Jiménez-Cervantes, Conchi, Olivares   +3 more
openaire   +2 more sources

Coat Color of Korean Brindle Cattle and Melanocortin 1 Receptor (MC1R) mRNA: Variation of 3'-Untranslated Region and Expression

Journal of Animal Reproduction and Biotechnology, 2014
The objective of this study was to determine the breed differences in the 3'-untranslated region (UTR) of MC1R mRNA, which may be used to distinguish Korean brindle cattle (Chikso) from other breeds. We investigated the relationship between the variation
Hae-Lee Lee, Jae-Hee Park, Jong Gug Kim
doaj   +1 more source

Use of domesticated pigs by Mesolithic hunter-gatherers in northwestern Europe [PDF]

, 2013
Acknowledgements We thank the Archaeological State Museum Schleswig-Holstein, the Archaeological State Offices of Brandenburg, Lower Saxony and Saxony and the following individuals who provided sample material: Betty Arndt, Jo¨rg Ewersen, Frederick ...
A Cooper, A Evin, A Scheu, BM Ursing, CJ Edwards, EA Koutsogiannouli, EJ Lee, FJ Rohlf, G Larson, G Larson, G Larson, HJ Bandelt, J Tamariz, JM Kijas, L Andersson, M Fang, M Scandura, MA Zeder, OE Craig, P Dolukhanov, P Rowley-Conwy, P Rowley-Conwy, P Rowley-Conwy, R Bollongino, R Bollongino, S Champlot, S Payne, SH Andersen, SH Andersen, T Cucchi, TL Fulton, UH Frey, V Fajardo, W Haak   +33 more
core   +1 more source

The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus

Pigment Cell & Melanoma Research, 2021
Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual ...
Doreen Schwochow, Susanne Bornelöv, Ting-Xing Jiang, Jingyi Li, D. Gourichon, B. Bed’hom, B. Dorshorst, C. Chuong, M. Tixier-Boichard, L. Andersson   +9 more
semanticscholar   +1 more source

A simple DNA based method for determination of pure Black Slavonian pigs

Italian Journal of Animal Science, 2010
The aim of this work was to determine the MC1R genotype of Black Slavonian pigs and to find an efficient and simple PCR-RFLP method, based on differences in MC1R genotype, to distinguish between purebred Black Slavonian pigs and their crossings with ...
Polona Margeta, Damir Jakšić, Peter Dovč, Gordana Kralik, Vladimir Margeta   +4 more
doaj   +1 more source

Spotlight on islands.On the origin and diversification of an ancient lineage of the Italian wall lizard Podarcis siculus in the western Pontine Islands [PDF]

, 2018
Groups of proximate continental islands may conceal more tangled phylogeographic patterns than oceanic archipelagos as a consequence of repeated sea level changes, which allow populations to experience gene flow during periods of low sea level stands and
Castiglia, Riccardo, DE SIMONE, Emanuela, Havenstein, Katja, Milana, Valentina, Ripa, Chiara, Senczuk, Gabriele, Tiedemann, Ralph   +6 more
core   +3 more sources

Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor.

PLoS ONE, 2015
The melanocortin 1 receptor gene (MC1R) expressed in melanocytes is a major determinant of skin pigmentation. It encodes a Gs protein-coupled receptor activated by α-melanocyte stimulating hormone (αMSH).
Cecilia Herraiz, Conchi Olivares, Maria Castejón-Griñán, Marta Abrisqueta, Celia Jiménez-Cervantes, José Carlos García-Borrón   +5 more
doaj   +1 more source