Results 101 to 110 of about 4,530 (193)

Obesity and Appetite Control [PDF]

, 2012
Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity.
Bloom, SR, Jayasena, CN, Suzuki, K
core   +2 more sources

Distinct Impact of Inflammatory Versus Psychophysiological Stress on Brain‐Wide Activation of Melanocortin Receptor 4–Expressing Neurons

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
Restraint stress and LPS‐induced inflammation commonly decrease food intake and body weight in male mice. Although both stressors increased c‐Fos expression in the PVN, the activation patterns diverge in several key brain regions. Restraint stress preferentially increased c‐Fos expression in the lateral septum, ventral BNST, and BLA, whereas LPS ...
Myunghyun Cheon, Woonhee Kim, ChiHye Chung   +2 more
wiley   +1 more source

Sweet Regulation of Melanocortin Receptor (MC1R, Mc3r, and MC4R) Transcription Activity

International Journal of Endocrinology and Metabolic Disorders, 2016
Objective: This study is to understanding the transcription profile of nociception-related melanocortin receptor MC1R, obesity related neural melanocortin receptor Mc3r and MC4R. Methods: For MC1R, Mc3r and MC4R, relative luciferase activity RLA and the distribution of phosphorylation [P], glycosylation sites [G] on transcription factor for promoter ...
openaire   +1 more source

Sex differences in basal hypothalamic anorectic and orexigenic gene expression and the effect of quantitative and qualitative food restriction [PDF]

, 2018
Background Research into energy balance and growth has infrequently considered genetic sex, yet there is sexual dimorphism for growth across the animal kingdom.
A Heck, AP Arnold, BJ Tolkamp, BK Podisi, BL Nielsen, C Zhang, CJ Savory, D Amadon, D Huszar, D Rigaud, D Zhao, E Decuypere, G Grabauskas, G Maniatis, GB Havenstein, GJ Davies, H Hara, Health EPoA, Welfare, IC De Jong, IC De Jong, IC Dunn, IC Dunn, IC Dunn, J Chue, J Zhang, JA Mench, JJ Lees, JM Brum, JW McRorie Jr, K Ralls, L Lei, L Wang, L Yuan, LG Frank, LK Burke, LM Dixon, M Andersson, M Clinton, M Graham, M Mohammadrezaei, M Perez-Miranda, MJ Fennell, MK Ling, N Goto, N Loganathan, OA Tashani, P Lal, PM Hocking, PM Hocking, R Guillot, R Sears, RJ Agate, T Boswell, T Boswell, T Tachibana, T Tachibana, TM Hahn, V Remes, V Sandilands, V Sandilands, XQ Chen, Z Song   +61 more
core   +2 more sources

Mechanisms and pharmacotherapy of cancer cachexia‐associated anorexia

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
Drugs for the treatment of cancer cachexia‐associated anorexia: their mechanisms and recommendations in each guideline. Abstract Cachexia is a multifactorial metabolic syndrome characterized by weight and skeletal muscle loss caused by underlying illnesses such as cancer, heart failure, and renal failure.
Ryosuke Sato, Guilherme Wesley Peixoto da Fonseca, Willian das Neves, Stephan von Haehling   +3 more
wiley   +1 more source

Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro

Frontiers in Pharmacology, 2018
It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq-coupling.
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure   +5 more
doaj   +1 more source

Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis

AbstractAlthough mammals resist both acute weight loss and weight gain, the neural circuitry mediating bi-directional defense against weight change is incompletely understood. Global constitutive deletion of the melanocortin-3-receptor (MC3R) impairs the behavioral response to both anorexic and orexigenic stimuli, with MC3R knockout mice demonstrating ...
Possa-Paranhos, Ingrid Camila, Butts, Jared, Pyszka, Emma, Nelson, Christina, Cho, Dajin, Sweeney, Patrick   +5 more
openaire   +2 more sources

MC3R activation does not attenuate pro‐inflammatory macrophage‐induced reductions in myoblast proliferation

The FASEB Journal, 2013
Background Activation of the melanocortin‐3‐receptor (MC3R) has potent anti‐inflammatory effect on macrophages. Acute muscle injury (AMI) is followed by an invasion of pro‐inflammatory macrophages (MΦ1). Objective The objective of this
David S Kump, Sarah Brooks, Rachel A Kump   +2 more
openaire   +1 more source

Reconsidering the Diagnosis: Abnormal Sweat Chloride Tests in Non‐CF Bronchiectasis

Pediatric Pulmonology, Volume 60, Issue 1, January 2025.
ABSTRACT Introduction While the diagnosis of cystic fibrosis (CF) is often straightforward and reliant on correlation between genetic testing and clinical signs and symptoms, there is a subset where the distinction is not nearly as clearcut. This has previously been reported in patients identified through newborn screening but not meeting full CF ...
Reyna L. Huang, Matthew T. Snyder, Nuzhat Fahmida, Dana P. Albon   +3 more
wiley   +1 more source

RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP‐1 as novel regulators of LFA‐1‐mediated T cell polarity and migration

Immunology &Cell Biology, Volume 103, Issue 1, Page 73-92, January 2025.
In this study, we screened RNAi libraries, targeting kinases and G protein‐coupled receptors/G protein‐coupled receptor associated proteins for regulators of T‐cell polarity and migration. We identified that Gβ1, casein kinase 2 and ICAP‐1 play key roles in T‐cell adhesion, polarity and migration on ICAM‐1.
Antje Haap‐Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia, Joanna Skubis‐Zegadlo, Anthony Mitchell Davies, Dermot Kelleher, Aideen Long   +9 more
wiley   +1 more source