Results 121 to 130 of about 63,660 (228)

Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]

, 2009
Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Bekel, A., Breidert, M., Eftekhari, P., Hofbauer, K. G., Kessler, L., Lecourt, A. C., Muller, S., Nesslinger, M., Peter, J. C., Zipfel, G.   +9 more
core   +3 more sources

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources

A mouse model for a partially inactive obesity-associated human MC3R variant

Nature Communications, 2016
The melanocortin receptor, MC3R, regulates organismal energy homeostasis. Here, Lee et al. create knock-in mice with the a mutated version of the human MC3R receptor found in obese children, and show these mice have more fat and smaller bone, yet are by ...
Bonggi Lee, Jashin Koo, Joo Yun Jun, Oksana Gavrilova, Yongjun Lee, Arnold Y. Seo, Dezmond C. Taylor-Douglas, Diane C. Adler-Wailes, Faye Chen, Ryan Gardner, Dimitri Koutzoumis, Roya Sherafat Kazemzadeh, Robin B. Roberson, Jack A. Yanovski   +13 more
doaj   +1 more source

Melanocortin receptor agonists suppress experimental autoimmune uveitis. [PDF]

Exp Eye Res, 2022
Ng TF, Dawit K, Taylor AW.
europepmc   +1 more source

A Novel Mutation in Melanocortin Receptor 2 and a Reported Mutation in Melanocortin Receptor 2 Accessory Protein: Three Chinese Cases with Familial Glucocorticoid Deficiency. [PDF]

Mol Syndromol, 2023
Duan Y, Xia Y, Gong Z, Liu H, Liang L, Zhang K, Yang Y, Wang R, Xiao B, Qiu W.   +9 more
europepmc   +1 more source

Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain. [PDF]

Front Mol Neurosci, 2023
Hall MAL, Kohut-Jackson AL, Peyla AC, Friedman GD, Simco NJ, Borland JM, Meisel RL.   +6 more
europepmc   +1 more source

Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression. [PDF]

Int J Mol Sci, 2022
Amin M, Ott J, Wu R, Postolache TT, Gragnoli C.   +4 more
europepmc   +1 more source

Convergent changes in melanocortin receptor 1 gene are associated with black-headed coat color in sheep. [PDF]

J Anim Sci, 2023
Zhou Q, Cao C, Zhang H, Liang Y, Zhang X, Kang Y, Fang W, Lan X, Li R, Pan C.   +9 more
europepmc   +1 more source

Spiro-naphthyridine Antagonists of the Melanocortin Receptor 4 for the Treatment of Cachexia Associated with Chronic Illness. [PDF]

ACS Med Chem Lett, 2022
Rosse G.
europepmc   +1 more source

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. [PDF]

Neuropeptides, 2022
Eliason NL, Martin L, Low MJ, Sharpe AL.
europepmc   +1 more source