Results 141 to 150 of about 47,532 (196)

Melanocortins and their Receptors and Antagonists

Current Drug Targets, 2003
The melanocortins are a group of small protein hormones derived by post-translational cleavage of the proopiomelanocortin (POMC) gene product. The known melanocortin hormones include alpha-melanocyte stimulating hormone (MSH), beta-MSH, gamma-MSH and adrenocorticotropic hormone (ACTH).
Voisey, J, Carroll, L, van Daal, A
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Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor

Gene, 2007
The melanocortin type 1 receptor (Mc1r) belongs to a family of G-protein-coupled receptors involved in various physiological processes in vertebrates. Melanocortins, the Mcr natural agonists, are pituitary peptide hormones including adrenocorticotropin and melanocyte-stimulating hormones.
Yvonne, Selz, Ingo, Braasch, Carsten, Hoffmann, Cornelia, Schmidt, Christina, Schultheis, Manfred, Schartl, Jean-Nicolas, Volff   +6 more
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Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors

General and Comparative Endocrinology, 2013
The melanocortin system integrates different agonists, competitive or inverse agonists, and receptors. Recent investigations have also discovered a specific system of melanocortin receptor accessory proteins (MRAPs) that are involved in the regulation of the functional expression of these receptors.
Cerdá-Reverter, José Miguel, Agulleiro Gozalbo, Maria Josep, Cortés, Raúl, Sánchez Martínez, Elisa, Guillot, Raúl, Leal, Esther, Fernández-Durán, Begoña, Puchol, Sara, Eley, M.   +8 more
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New ligands for melanocortin receptors

International Journal of Obesity, 2008
Named originally for their effects on peripheral end organs, the melanocortin system controls a diverse set of physiological processes through a series of five G-protein-coupled receptors and several sets of small peptide ligands. The central melanocortin system plays an essential role in homeostatic regulation of body weight, in which two alternative ...
C B, Kaelin, S I, Candille, B, Yu, P, Jackson, D A, Thompson, M A, Nix, J, Binkley, G L, Millhauser, G S, Barsh   +8 more
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Melanocortin-5 receptor and sebogenesis

European Journal of Pharmacology, 2011
The melanocortins (α-MSH, β-MSH, γ-MSH, and ACTH) bind to the melanocortin receptors and signal through increases in cyclic adenosine monophosphate to induce biological effects. The melanocortin MC(5) and MC(1) receptors are expressed in human sebaceous glands, which produce sebum, a lipid mixture of squalene, wax esters, triglycerides, cholesterol ...
Li, Zhang, Wen-Hwa, Li, Michael, Anthonavage, Apostolos, Pappas, Dianne, Rossetti, Druie, Cavender, Miri, Seiberg, Magdalena, Eisinger   +7 more
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Melanocortin Receptors and Erectile Function

European Urology, 2004
Review the historical and current evidence that suggests that activation of melanocortin receptors modulates erectile activity.The available literature was reviewed.Melanocortin peptides derived from the pro-opiomelanocortin (POMC) precursor protein exert a host of diverse physiological effects in the periphery and in the CNS through interactions with ...
William J, Martin, D Euan, MacIntyre
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Molecular Modeling of Melanocortin Receptors

Current Topics in Medicinal Chemistry, 2007
Molecular modeling of G-protein coupled receptors (GPCRs) remains a challenge due to the limited availability of structural information for the receptors. Molecular modeling approaches for melanocortin receptors (MCRs) fall into three categories: structure-based, ligand-based, and proteochemometric.
Hongmao, Sun, David, Fry
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New aspects on the melanocortins and their receptors

Pharmacological Research, 2000
Knowledge of melanocortins and their receptors has increased tremendously over the last few years. The cloning of five melanocortin receptors, and the discovery of two endogenous antagonists for these receptors, agouti and agouti-related peptide, have sparked intense interest in the field.
J E, Wikberg, R, Muceniece, I, Mandrika, P, Prusis, J, Lindblom, C, Post, A, Skottner   +6 more
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The Melanocortin Receptors

2000
Part I: Historical Perspectives. Proopiomelanocortin and the Melanocortin Peptides, A. N. Eberle. Melanocortins and Pigmentation, A. B. Lerner. Melanocortins and Adrenocortical Function, M. Begeot and J. M. Saez. Effects of Melanocortins in the Nervous System, R. A. H. Adan. Peripheral Effects of Melanocortins, B. A. Boston. Part II.
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Evolution of melanocortin receptors in cartilaginous fish: Melanocortin receptors and the stress axis in elasmobranches

General and Comparative Endocrinology, 2013
There is general agreement that the presence of five melanocortin receptor genes in tetrapods is the result of two genome duplications that occurred prior to the emergence of the gnathostomes, and at least one local gene duplication that occurred early in the radiation of the ancestral gnathostomes.
Liang, Liang, Christina, Reinick, Joseph K, Angleson, Robert M, Dores   +3 more
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