Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections. [PDF]
Curr Opin Immunol, 2021 Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly ...
Liszewski MK, Atkinson JP.
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Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki +4 more
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Induction of decay accelerating factor and membrane cofactor protein by resveratrol attenuates complement deposition in human coronary artery endothelial cells [PDF]
Biochemistry and Biophysics Reports, 2019 The involvement of complement activation in various forms of cardiovascular disease renders it an important factor for disease progression and therapeutic intervention.
Maria G. Detsika +5 more
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Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs [PDF]
Journal of Neuroinflammation, 2004 Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L +2 more
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Functional properties of membrane cofactor protein of complement [PDF]
Biochemical Journal, 1989 Membrane cofactor protein (MCP or gp45-70) of the complement system is a cofactor for factor I-mediated cleavage of fluid-phase C3b and C3b-like C3, which opens the thioester bond. In the present study the activity of MCP was further characterized. Unexpectedly, in the absence of factor I, MCP stabilized the alternative- and, to a lesser extent, the ...
Tsukasa Seya, John Atkinson
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Biochemical characterization of membrane cofactor protein of the complement system. [PDF]
The Journal of Immunology, 1988 Abstract Membrane cofactor protein (MCP; formerly termed glycoprotein 45-70 to indicate its Mr) of complement is a widely distributed iC3/C3b binding protein with co-factor activity. On human mononuclear cells and cell lines and platelets, MCP is a doublet.
L L Ballard +3 more
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Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)?
Cancer Immunology, Immunotherapy, 2004 CD46 or membrane cofactor protein (MCP) is a complement regulatory protein that has been identified on all nucleated cells and which protects them from attack by autologous complement. Breast carcinomas are reported to consistently express CD46.Our previous immunohistochemical study showed that in breast carcinomas, loss of CD59 and CD55 correlated ...
Zahra Madjd +7 more
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Membrane cofactor protein (MCP; CD46) expression in transgenic mice [PDF]
Clinical and Experimental Immunology, 2001 SUMMARYHuman membrane cofactor protein (MCP; CD46) is a widely distributed complement regulator. In the mouse, expression of MCP is largely restricted to the testis while a related, widely expressed protein (Crry) appears to perform MCP's (CD46) regulatory activity.
Claudia Kemper +6 more
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Cooperation of decay-accelerating factor and membrane cofactor protein in regulating survival of human cervical cancer cells [PDF]
BMC Cancer, 2009 Background Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts the action of complement at critical stages of the cascade reaction.
Gong Hui +7 more
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Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. [PDF]
Oncol Rep, 2014 Lu Z +10 more
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