Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki +4 more
doaj +4 more sources
Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections. [PDF]
Curr Opin Immunol, 2021 Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly ...
Liszewski MK, Atkinson JP.
europepmc +5 more sources
CD46 (membrane cofactor protein) associates with multiple β1 integrins and tetraspans [PDF]
European Journal of Immunology, 2000 The tetraspans associate with a large number of surface molecules, including a subset of beta1 integrins and, indirectly through CD19, with the complement receptor CD21. To further characterize the tetraspan complexes we have raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9.
Stéphanie Lozahic +6 more
semanticscholar +8 more sources
New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3. [PDF]
Biosci Rep, 2014 aHUS (atypical haemolytic uraemic syndrome), AMD (age-related macular degeneration) and other diseases are associated with defective AP (alternative pathway) regulation. CFH (complement factor H), CFI (complement factor I), MCP (membrane cofactor protein)
Rodriguez E +3 more
europepmc +4 more sources
Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. [PDF]
Oncol Rep, 2014 The therapeutic potential of membrane complement regulatory protein (mCRP)-neutralizing antibodies is unsatisfactory, which perhaps lies in the complex role of mCRPs in tumor occurrence and development. As a member of the mCRPs, CD46 is a transmembrane protein with a cytoplasmic domain and is implicated more in the control of the alternative complement
Lu Z +10 more
europepmc +6 more sources
A polymorphism of the complement regulatory protein MCP (membrane cofactor protein or gp45-70). [PDF]
The Journal of Immunology, 1987 Abstract Membrane cofactor protein (MCP or gp45-70) is a recently described regulatory glycoprotein of the complement system which binds iC3 or C3b and is present on human platelets, T cells, B cells, monocytes, and mononuclear-derived cell lines.
L. Ballard +4 more
semanticscholar +4 more sources
Biochemical characterization of membrane cofactor protein of the complement system. [PDF]
The Journal of Immunology, 1988 Abstract Membrane cofactor protein (MCP; formerly termed glycoprotein 45-70 to indicate its Mr) of complement is a widely distributed iC3/C3b binding protein with co-factor activity. On human mononuclear cells and cell lines and platelets, MCP is a doublet.
L L Ballard +3 more
semanticscholar +4 more sources
Membrane Cofactor Protein (MCP; CD46): Isoform-Specific Tyrosine Phosphorylation [PDF]
The Journal of Immunology, 2000 Abstract Membrane cofactor protein (MCP; CD46) is a widely expressed type 1 transmembrane glycoprotein that inhibits complement activation on host cells. It also is a receptor for several pathogens including measles virus, Streptococcus pyogenes, Neisseria gonorrhea, and Neisseria meningitidis.
Guixian Wang +3 more
semanticscholar +6 more sources
Functional properties of membrane cofactor protein of complement [PDF]
Biochemical Journal, 1989 Membrane cofactor protein (MCP or gp45-70) of the complement system is a cofactor for factor I-mediated cleavage of fluid-phase C3b and C3b-like C3, which opens the thioester bond. In the present study the activity of MCP was further characterized. Unexpectedly, in the absence of factor I, MCP stabilized the alternative- and, to a lesser extent, the ...
Tsukasa Seya, John P. Atkinson
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Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3' end of the C3b/C4b receptor gene. [PDF]
Journal of Experimental Medicine, 1989 The structural gene for membrane cofactor protein (MCP), a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system, has been mapped to the same locus as the structural genes for CR1, CR2, DAF, and C4bp.
Nalini S. Bora +5 more
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