Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki +4 more
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Characterization of CR1- and membrane cofactor protein-like proteins of two primates. [PDF]
The Journal of Immunology, 1990 Abstract We have identified and characterized C3b binding proteins of two primates, orangutan (Pongo pygmaeus) and gorilla (Gorilla gorilla). Detergent solubilized 125I surface-labeled E and PBMC were subjected to affinity chromatography with homologous or human iC3/C3b. These ligands bound a 225,000 single chain protein from orangutan E
M W, Nickells, J P, Atkinson
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Expression and characterization of CD46, membrane cofactor protein, in human colonic mucosa.
Japanese Journal of Clinical Immunology, 1996 CD 46, membrane cofactor protein (MCP), is a membrane regulatory glycoprotein of the complement system, and acts as a cofactor of factor I, which inactivates C3b and C4b bound on autologous cell membrane. MCP is present on human peripheral blood cells except erythrocytes, fibroblasts, epithelial and endothelial cells, and has been proved to exist in ...
S, Nakanishi +10 more
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Do poor-prognosis breast tumours express membrane cofactor proteins (CD46)?
Cancer Immunology, Immunotherapy, 2004 CD46 or membrane cofactor protein (MCP) is a complement regulatory protein that has been identified on all nucleated cells and which protects them from attack by autologous complement. Breast carcinomas are reported to consistently express CD46.Our previous immunohistochemical study showed that in breast carcinomas, loss of CD59 and CD55 correlated ...
Madjd, Zahra +7 more
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Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance to xenotransplantation [PDF]
Immunology, 1999 Membrane cofactor protein (MCP; CD46) is a 50–60 000 MW glycoprotein, expressed on a wide variety of cells and tissues in man, which plays an important role in regulating complement activation. Human MCP has also been shown to be the receptor for measles virus.
J M, Pérez de la Lastra +2 more
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Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma [PDF]
Oncol Rep, 2013 Zejun Lu +10 more
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Correction: Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 PLOS ONE Staff
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Membrane Cofactor Protein (CD46) Is a Basolateral Protein That Is Not Endocytosed [PDF]
Journal of Biological Chemistry, 1997 Andrea Maisner +5 more
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Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy
Frontiers in Immunology, 2022 The origin of the impaired CD4 T-cell response and immunodeficiency of HIV-infected patients is still only partially understood. We recently demonstrated that PLA2G1B phospholipase synergizes with the HIV gp41 envelope protein in HIV viremic plasma to ...
Julien Pothlichet +11 more
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Structure of the Methanosarcina mazei Mtr complex bound to the oxygen-stress responsive small protein MtrI [PDF]
Nature CommunicationsMethanogenic archaea emit ~1 Gt of methane annually, impacting global carbon cycling and climate. Central to their energy metabolism is a membrane-bound, sodium-translocating methyltransferase complex: the N⁵-tetrahydromethanopterin:CoM-S ...
Tristan Reif-Trauttmansdorff +8 more
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