Membrane cofactor protein (MCP; CD46) expression in transgenic mice [PDF]
Clinical and Experimental Immunology, 2001 SUMMARYHuman membrane cofactor protein (MCP; CD46) is a widely distributed complement regulator. In the mouse, expression of MCP is largely restricted to the testis while a related, widely expressed protein (Crry) appears to perform MCP's (CD46) regulatory activity.
Claudia Kemper +6 more
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Correction: Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies. [PDF]
PLoS ONE, 2015 PLOS ONE Staff
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Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs [PDF]
Journal of Neuroinflammation, 2004 Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L +2 more
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Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1995 The human complement regulatory protein membrane cofactor protein (CD46) is the cellular receptor for measles virus (MV), whereas decay accelerating factor (DAF; CD55), a structurally similar complement regulatory protein, does not bind MV.
Marianne Manchester +7 more
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Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus [PDF]
Journal of Virology, 1993 A monoclonal antibody (MCI20.6) which inhibited measles virus (MV) binding to host cells was previously used to characterize a 57- to 67-kDa cell surface glycoprotein as a potential MV receptor. In the present work, this glycoprotein (gp57/67) was immunopurified, and N-terminal amino acid sequencing identified it as human membrane cofactor protein ...
Naniche, D +6 more
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Membrane Cofactor Protein (CD46) Is a Basolateral Protein That Is Not Endocytosed [PDF]
Journal of Biological Chemistry, 1997 Membrane cofactor protein (MCP) is a widely distributed complement regulatory protein that is expressed on the basolateral surface of polarized epithelial cells. The basolateral targeting of the BC1 isoform of MCP was analyzed by generating deletion mutants and point mutants within the cytoplasmic tail of 16 amino acids. A sequence of four amino acids,
Andrea Maisner +5 more
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Membrane Cofactor Protein Is a Receptor for Adenoviruses Associated with Epidemic Keratoconjunctivitis [PDF]
Journal of Virology, 2004 ABSTRACTSubgroup D adenovirus (Ad) types 8, 19, and 37 (Ad8, -19, and -37, respectively) are causative agents of epidemic keratoconjunctivitis and genital tract infections. Previous studies showed that Ad37 binds to a 50-kDa membrane glycoprotein expressed on human ocular (conjunctival) cells.
Lars Pache +6 more
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A Novel and Ubiquitous System for Membrane Targeting and Secretion of Cofactor-Containing Proteins [PDF]
Cell, 1998 We report the identification of the proteins encoded by the mttABC operon (formerly yigTUW), which mediate a novel Sec-independent membrane targeting and translocation system in Escherichia coli that interacts with cofactor-containing redox proteins having a S/TRRXFLK "twin arginine" leader motif.
Joël H. Weiner +7 more
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BMC Cancer, 2009 Background Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts the action of complement at critical stages of the cascade reaction.
Gong Hui +7 more
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Membrane targeting of a folded and cofactor-containing protein [PDF]
European Journal of Biochemistry, 2003 Targeting of proteins to and translocation across the membranes is a fundamental biological process in all organisms. In bacteria, the twin arginine translocation (Tat) system can transport folded proteins. Here, we demonstrate in vivo that the high potential iron‐sulfur protein (HiPIP) from Allochromatium vinosum is translocated into the periplasmic ...
Thomas Brüser +3 more
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