Polymorphism and proteolytic fragments of granulocyte membrane cofactor protein (MCP, CD46) of complement [PDF]
Biochemical Journal, 1992 Human granulocytes (polymorphonuclear leucocytes, PMN) possess a membrane cofactor protein (MCP, CD46), which is structurally and functionally distinct from the MCPs of other cell types: it shows a single broad band of 56-80 kDa (without the doublet pattern characteristic of MCP) on SDS/PAGE and has less affinity for complement component C3b.
Misako Matsumoto +2 more
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Molecular cloning of a pig homologue of membrane cofactor protein (CD46) [PDF]
International Immunology, 1997 Organs of transgenic pigs that express human complement regulatory proteins are under assessment as an alternative to transplantation. A major barrier to the transplantation of pig organs is the hyperacute rejection caused by pre-existing antibodies and complement.
Keigo Toyomura
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Characterization of the promoter region of the membrane cofactor protein (CD46) gene of the human complement system and comparison to a membrane cofactor protein-like genetic element. [PDF]
The Journal of Immunology, 1993 Abstract Membrane cofactor protein (MCP; CD46) is a widely expressed C regulatory protein that inhibits C activation on self-tissue. MCP binds C3b and C4b deposited on autologous cells and then serves as a cofactor for their inactivation by limited proteolytic cleavage.
Wen Cui +5 more
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Protective effect of membrane cofactor protein against complement-dependent injury [PDF]
Acta Pharmacologica Sinica, 2005 To evaluate the protective role of membrane cofactor protein (MCP, CD46) on complement-dependent injury.MCP was separated by ion exchange chromatography on a DEAE sephadex A-50 column from pig erythrocyte ghosts. Its protective effect was tested in models such as cobra venom factor (CVF)-induced platelet metamorphosis and aggregation, human serum ...
Dong Xu +3 more
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Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome [PDF]
Blood, 2007 The hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Genetic studies demonstrate that heterozygous mutations of membrane cofactor protein (MCP;CD46) predispose to atypical HUS (aHUS),
Celia J. Fang +6 more
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Presence of the complement-regulatory protein membrane cofactor protein (MCP, CD46) as a membrane-associated product in seminal plasma [PDF]
Reproduction, 1994 The seminal plasma complement regulator membrane cofactor protein (MCP) was examined by sequential centrifugation and phase separation in the detergent Triton X-114. The presence of MCP components in seminal plasma depleted of the 40 kDa sperm MCP product by low speed centrifugation was confirmed.
K L Simpson, C H Holmes
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Induction of decay accelerating factor and membrane cofactor protein by resveratrol attenuates complement deposition in human coronary artery endothelial cells [PDF]
Biochemistry and Biophysics Reports, 2019 The involvement of complement activation in various forms of cardiovascular disease renders it an important factor for disease progression and therapeutic intervention.
Maria G. Detsika +5 more
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Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46) [PDF]
Journal of Biological Chemistry, 2000 Membrane cofactor protein (MCP; CD46), a widely distributed regulator of complement activation, is a cofactor for the factor I-mediated degradation of C3b and C4b deposited on host cells.
M. Kathryn Liszewski +7 more
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Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. [PDF]
Proceedings of the National Academy of Sciences, 1995 The pathogenic Gram-positive bacterium Streptococcus pyogenes (group A streptococcus) is the causative agent of numerous suppurative diseases of human skin. The M protein of S. pyogenes mediates the adherence of the bacterium to keratinocytes, the most numerous cell type in the epidermis.
John P. Atkinson +3 more
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Expression of membrane cofactor protein (MCP, CD46) in human liver diseases [PDF]
British Journal of Cancer, 1999 Membrane cofactor protein (MCP, CD46) is one of the complement regulatory proteins, and is widely distributed in human organs and protects cells from complement-mediated cytotoxicity. We analysed the distribution and the intensities of MCP in liver diseases and evaluated the role of MCP during hepatocarcinogenesis.
N Kinugasa +9 more
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