Results 1 to 10 of about 28,381 (165)

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss [PDF]

MedComm
Somatic retinoblastoma 1 (RB1) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a direct druggable ...
Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu   +21 more
doaj   +2 more sources

Does CytoSorb Interfere with Immunosuppression? A Pharmacokinetic and Functional Evaluation [PDF]

Pharmaceutics
Background/Objectives: Cytokine release during organ transplantation contributes to primary graft dysfunction and requires careful immunomodulation. CytoSorb, a hemoadsorption device developed to reduce circulating cytokine levels, is increasingly used ...
Stephan Harm, Claudia Schildböck, Denisa Cont, Viktoria Weber, Jens Hartmann   +4 more
doaj   +2 more sources

Use of thiopurines in inflammatory bowel disease: an update [PDF]

Intestinal Research, 2022
Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight.
Arshdeep Singh, Ramit Mahajan, Saurabh Kedia, Amit Kumar Dutta, Abhinav Anand, Charles N. Bernstein, Devendra Desai, C. Ganesh Pai, Govind Makharia, Harsh Vardhan Tevethia, Joyce WY Mak, Kirandeep Kaur, Kiran Peddi, Mukesh Kumar Ranjan, Perttu Arkkila, Rakesh Kochhar, Rupa Banerjee, Saroj Kant Sinha, Siew Chien Ng, Stephen Hanauer, Suhang Verma, Usha Dutta, Vandana Midha, Varun Mehta, Vineet Ahuja, Ajit Sood   +25 more
doaj   +1 more source

Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

Journal of Electrochemical Science and Engineering, 2021
A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad, Jamileh Seyed-Yazdi, Seyedeh Hoda Hekmatara   +2 more
doaj   +1 more source

Cơ chế hấp phụ và sự tăng cường hóa học phổ SERS của mercaptopurine và thioguanine trên bề mặt Au6 cluster

Tạp chí Khoa học Đại học Cần Thơ, 2022
Các phép tính DFT (lý thuyết hàm mật độ) được sử dụng để làm sáng tỏ bản chất của quá trình hấp phụ các phân tử thuốc mercaptopurine (MP) và thioguanine (TG) trên bề mặt vàng, sử dụng Au6 cluster làm mô hình phản ứng.
Nguyễn Thị Nhật Hằng, Nguyễn Thành Tiên, Dương Thị Huyền, Nguyễn Thanh Sĩ, Phạm Vũ Nhật   +4 more
doaj   +1 more source

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2020
A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15.
Minyuan Cao, Minyuan Cao, Dandan Yin, Yun Qin, Fei Liao, Yali Su, Xuyang Xia, Ju Gao, Yiping Zhu, Wei Zhang, Yang Shu, Xiaoxi Lu   +11 more
doaj   +1 more source

Immune‐related adverse events in hepatitis treated with thiopurine‐based immunosuppressants: A case report

Thoracic Cancer, 2023
An 82‐year‐old man was treated with ipilimumab and nivolumab for malignant pleural mesothelioma. Although he was previously treated with prednisolone (1 mg/kg/day) for immune‐related adverse event (irAE) hepatitis by a previous doctor, he still had ...
Keita Kawakado, Kazuhisa Nakashima, Hiroshi Tobita, Mamiko Nagase, Ken Yoshihara, Mika Horie, Megumi Hamaguchi, Tamio Okimoto, Yukari Tsubata, Takeshi Isobe   +9 more
doaj   +1 more source

NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

Frontiers in Pediatrics, 2022
BackgroundThiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression.
Fang Zhang, Gulbanur Amat, Yanjing Tang, Ru Chen, Xin Tian, Wenting Hu, Changcheng Chen, Shuhong Shen, Yangyang Xie   +8 more
doaj   +1 more source

Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease

Toxics, 2022
The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications.
Oliwia Zakerska-Banaszak, Liliana Łykowska-Szuber, Michał Walczak, Joanna Żuraszek, Aleksandra Zielińska, Marzena Skrzypczak-Zielińska   +5 more
doaj   +1 more source

Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease [PDF]

, 2014
Background Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions.
Angelberger, Angelberger, Ardizzone, Armuzzi, Armuzzi, Armuzzi, Benchimol, Bernell, Colonna, D'Haens, D'Haens, Dilger, Doherty, Ferrante, Gordon, Guyatt, Hafraoui, Hanauer, Hanauer, Herfarth, Herfarth, Higgins, Higgins, Korelitz, Manosa, Mañosa, Nos, Pitkin, Prefontaine, Regueiro, Reinisch, Reinisch, Reinisch, Reinisch, Rolfe, Rutgeerts, Savarino, Savarino, Savarino, Schünemann, Steinhart, Williams   +41 more
core   +1 more source