Results 31 to 40 of about 37,289 (232)

Allele-specific polymerase chain reaction can determine the diplotype of NUDT15 variants in patients with childhood acute lymphoblastic Leukemia

Scientific Reports, 2023
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian ...
Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Kang-Hsi Wu, Chao-Neng Cheng, Hsiu-Hao Chang, Shu-Wei Chou, Min-Yu Su, Yu-Ling Ni, Pei-Yuan Xu, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang   +17 more
doaj   +1 more source

Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia

Marine Drugs, 2018
For enhanced intracellular accumulation of 6-mercaptopurine (6-MP) in leukemia, a folate receptor-targeted and glutathione (GSH)-responsive polymeric prodrug nanoparticle was made.
Xuan Wei, Jianhong Liao, Zahra Davoudi, Hua Zheng, Jingru Chen, Dan Li, Xiong Xiong, Yihua Yin, Xiuxiang Yu, Jinghui Xiong, Qun Wang   +10 more
semanticscholar   +1 more source

Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug–Gene Pairs to Know

Pharmaceuticals, 2023
Gastroenterologists represent some of the earlier adopters of precision medicine through pharmacogenetic testing by embracing upfront genotyping for thiopurine S-methyltransferase nucleotide diphosphatase (TPMT) before prescribing 6-mercaptopurine or ...
Tracy Sandritter, Rachel Chevalier, Rebecca Abt, Valentina Shakhnovich   +3 more
doaj   +1 more source

Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy

Haematologica, 2021
Chemotherapy dosages are often compromised, but most reports lack data on dosages that are actually delivered. In two consecutive acute lymphoblastic leukemia trials that differed in their asparaginase formulation, native E.
Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling   +19 more
doaj   +1 more source

Adsorption Investigation of Boron Nitride Nanoparticle as Biodegradable Drug Delivery Carriers for the Mercaptopurine Anti-cancer Drug by Density Functional Theory [PDF]

Journal of Sciences, Islamic Republic of Iran
Cancer is one of the most common diseases that affects many people around the world, and one of the challenges of the scientific community in dealing with cancer is to deliver drugs to cancerous tumors.
Nasrin Masnabadi, Marjaneh Samadizadeh, Ladan Sardarzadeh   +2 more
doaj   +1 more source

Effect of preoperative thoracic duct drainage on canine kidney transplantation [PDF]

, 1996
Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days,
Archimbaud JP, Atsuhito Yagihashi, Depster WJ, Dumont AE, Fischer DC, Franksson C, Franksson C, Giuseppe Carrieri, Gowans JL, Harvey J, Janossy G, Johnson HK, Julius MH, Kawai T, Koep LJ, Kohler G, Krawiec DR, Lemke H, Machieder HI, McGregor DD, McKneally M, Medawar PB, Meeker W, Mukenzie JL, Murray JE, Mysliwietz JJ, Newton WT, Oh CY, Prendergast MM, Sales HE, Satoru Todo, Schwartz R, Shibata Y, Starzl TE, Starzl TE, Starzl TE, Thomas E. Starzl, Traeger J, Williamson E PM, Woodruff M FA, Wulff JC, Wulff JC, Yoichi Funakoshi, Yuichi Iwaki   +43 more
core   +1 more source

TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Dewi Selvina Rosdiana,1 Rianto Setiabudy,1 Rizka Andalusia,2,3 Djajadiman Gatot,4 Melva Louisa,1 Saptawati Bardosono,5 Instiaty Instiaty1 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia ...
Rosdiana DS, Setiabudy R, Andalusia R, Gatot D, Louisa M, Bardosono S, Instiaty I   +6 more
doaj  

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Alopecia as the first manifestation of azathioprine myelosuppression in a genetically predisposed patient

Indian Journal of Rheumatology, 2019
Azathioprine, an analog of mercaptopurine, is used for various inflammatory/autoimmune diseases in diverse fields such as rheumatology, ophthalmology, gastroenterology, and neurology.
Debashish Mishra, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain, Varun Dhir   +4 more
doaj   +1 more source

Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease. [PDF]

, 2018
AimTo determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn's disease (CD).MethodsCD patients [< chronological age (CA) 21 years] were
Andrews, Howard, Chao, Cewin, Gupta, Neera, Leu, Cheng-Shiun, Lustig, Robert H, Vittinghoff, Eric   +5 more
core   +1 more source