Results 51 to 60 of about 3,929 (170)

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Merkel Cell Carcinoma: The Past, the Present, and the Future

Journal of Skin Cancer, 2013
Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades.
Inamaria Erovic, Boban M. Erovic
doaj   +1 more source

Merkel cell carcinoma with seborrheic keratosis: A unique association

Indian Journal of Pathology and Microbiology, 2018
Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk.
Murthy S Anand, Shantha Krishnamurthy, Suvarna Ravindranath, Jyothi Ranganathan   +3 more
doaj   +1 more source

The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration

Virus Research, 2023
Recent studies have suggested that BK polyomavirus (BKPyV) may be associated with the development of urothelial carcinoma. In Merkel cell carcinoma, TAg and tAg are the major viral proteins of Merkel cell polyomavirus with oncogenic potential.
Jiun-Wen Wang, Yi-Jung Li, Hsin-Hsu Wu, Hsiang-Hao Hsu, Ming-Yang Chang, Robert YL Wang, Ya-Chung Tian   +6 more
doaj   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

Merkel Cell Carcinoma and Immunosuppression, UV Radiation, and Merkel Cell Polyomavirus.

JAMA Dermatol
ImportanceMerkel cell carcinoma (MCC) is a rare but aggressive skin cancer. Quantifying the contribution of major potentially modifiable risk factors to the burden of MCC may inform prevention efforts.ObjectiveTo estimate the population attributable fraction of MCC cases in the US that were attributable to major immunosuppressing conditions (eg, HIV ...
Tribble JT, Pfeiffer RM, Brownell I, Cahoon EK, Sargen MR, Shiels MS, Luo Q, Cohen C, Drezner K, Hernandez B, Moreno A, Pawlish K, Saafir-Callaway B, Engels EA, Volesky-Avellaneda KD.   +14 more
europepmc   +3 more sources

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges

Head &Neck, Volume 47, Issue 12, Page 3414-3428, December 2025.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Hunter A. Holley, Maria Lyons, Barry O'Sullivan, Neville Shine, Robbie Woods, Orla McArdle, James Paul O'Neill   +6 more
wiley   +1 more source

Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma [PDF]

JNCI: Journal of the National Cancer Institute, 2009
Merkel cell polyomavirus (MCPyV) has been detected in approximately 75% of patients with the rare skin cancer Merkel cell carcinoma. We investigated the prevalence of antibodies against MCPyV in the general population and the association between these antibodies and Merkel cell carcinoma.Multiplex antibody-binding assays were used to assess levels of ...
Carter, Joseph J., Paulson, Kelly G., Wipf, Greg C., Miranda, Danielle, Madeleine, Margaret M., Johnson, Lisa G., Lemos, Bianca D., Lee, Sherry, Warcola, Ashley H., Iyer, Jayasri G., Nghiem, Paul, Galloway, Denise A.   +11 more
openaire   +2 more sources

Incidental Merkel cell carcinoma in a cutaneous horn: a case report.

Dermatology Practical & Conceptual, 2019
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a “cutaneous horn” on the face.
Brian A. Schick, Joshua S. Tobe, Mariamma G. Joseph, Tyler B. Rouse, Manal Y. Gabril   +4 more
doaj   +1 more source

Immunological and Viral Profiles of Squamous Cell Carcinoma in Transplant and Non‐Transplant Patients in Singapore

JEADV Clinical Practice, Volume 4, Issue 5, Page 1101-1113, December 2025.
Cutaneous squamous cell carcinoma (cSCC) exhibits a pro‐tumorigenic immune environment, increased oncologic signalling, and tumour remodelling, with three immune subgroups from ‘cold’ to ‘hot’. Organ transplant recipients (OTR) with cSCC showed reduced T‐cells and greater viral enrichment, especially HPV, and a higher disease burden.
Choon Chiat Oh, Boon Yee Lim, Elizabeth Chun Yong Lee, Bavani Kannan, Po Yin Tang, Tun Kiat Ko, Clara Wei Teng Koh, Kuan Rong Chan, Jason Yongsheng Chan   +8 more
wiley   +1 more source