Results 11 to 20 of about 109,926 (267)
Metabolic reprogramming in cholangiocarcinoma [PDF]
Journal of Hepatology, 2022 Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the increased energy demands required for rapid proliferation, invasion, and metastasis. Indeed, many tumour cells acquire distinctive metabolic and bioenergetic features that enable them to survive in resource-limited conditions, mainly by harnessing alternative nutrients.
Chiara Raggi +4 more
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Metabolic Reprogramming of Liver Fibrosis [PDF]
Cells, 2021 Liver fibrosis is an excessive and imbalanced deposition of fibrous extracellular matrix (ECM) that is associated with the hepatic wound-healing response. It is also the common mechanism that contributes to the impairment of the liver function that is observed in many chronic liver diseases (CLD).
M. Eugenia Delgado +3 more
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Metabolic Reprogramming in COVID-19 [PDF]
International Journal of Molecular Sciences, 2021 Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease.
Shen, Tao, Wang, Tingting
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Metabolic reprogramming in prostate cancer [PDF]
British Journal of Cancer, 2021 AbstractAlthough low risk localised prostate cancer has an excellent prognosis owing to effective treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic prostate cancer remains incurable. Existing therapeutic regimens prolong life; however, they are beset by problems of resistance, resulting in poor outcomes.
Fahim Ahmad +2 more
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Immune cell metabolism and metabolic reprogramming
Molecular Biology Reports, 2022 Energy metabolism maintains the activation of intracellular and intercellular signal transduction, and plays a crucial role in immune response. Under environmental stimulation, immune cells change from resting to activation and trigger metabolic reprogramming. The immune system cells exhibit different metabolic characteristics when performing functions.
Chenchen Hu +5 more
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Metabolic reprogramming in macrophage responses [PDF]
Biomarker Research, 2021 AbstractMacrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment and play an important role in tumor initiation, growth, invasion, and metastasis.
Yang Liu +9 more
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Metabolic Reprogramming in Glioma [PDF]
Frontiers in Cell and Developmental Biology, 2017 Many cancers have long been thought to primarily metabolize glucose for energy production-a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the early twentieth century. Yet cancer cells also utilize other substrates, such as amino acids and fatty acids, to produce raw materials for cellular maintenance and energetic
Strickland, Marie, Stoll, Elizabeth A.
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Metabolic Reprograming in Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes ...
Silvia Galván-Peña +1 more
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Metabolic Reprogramming and Renal Fibrosis [PDF]
Frontiers in Medicine, 2021 There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to ...
Xiaoyu Zhu +5 more
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Metabolic Reprogramming during Microglia Activation [PDF]
Immunometabolism, 2019 AbstractMicroglia, the specialized macrophages of the brain, can adopt different shapes and functions, some of which may be detrimental for nervous tissue. Similar to other immune cells, the metabolic program may determine the phenotypic features of microglia, and could constitute a therapeutic target in neurological diseases.
Geric, Ivana +8 more
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