Results 41 to 50 of about 123,701 (265)

Metabolic reprogramming in efferocytosis

Frontiers in Cell and Developmental Biology
Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair.
Yan, Qing, Li, Kuo, Chen, Lu, Wang, Aowei, Xi, Yingying, Xiao, Hui, Yuan, Lei   +6 more
openaire   +3 more sources

Metabolic reprogramming in osteoclasts

Seminars in Immunopathology, 2019
Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of the bone. Defects in osteoclasts thus result in unbalanced bone remodeling, leading to numerous pathological conditions such as osteoporosis, bone metastasis, and inflammatory bone erosion.
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace

Discover Oncology
Objective Tumor-derived exosomes testing can be effective in diagnosing disease and assisting in the treatment of disease. Our study utilizes bibliometric analysis to identify research hotspots related to tumor-derived exosomes, predict emerging research
Ruijun Guo, Jiajun Xu, Chunxia Li, Chune Mo, Minglin Ou   +4 more
doaj   +1 more source

Clinical applications and challenges of CD40/CD40L signaling regulation in autoimmune diseases

Frontiers in Immunology
The CD40–CD40L axis is a central costimulatory pathway that links innate and adaptive immunity and contributes to autoimmune inflammation. However, CD40 signaling does not operate in the same way across cell types, and these differences are relevant to ...
Yangyang Man, Xiaoni Chen, Yi Liu, Biao Zhang, Jiahua Hu, Xianliang Hou, Xianliang Hou   +6 more
doaj   +1 more source

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

Stem Cell Reports, 2018
Summary: Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood.
Javier Prieto, Arnold Y. Seo, Marian León, Fulvio Santacatterina, Laura Torresano, Martina Palomino-Schätzlein, Karen Giménez, Azahara Vallet-Sánchez, Xavier Ponsoda, Antonio Pineda-Lucena, José M. Cuezva, Jennifer Lippincott-Schwartz, Josema Torres   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system

Stem Cell Research & Therapy
Background Autosomal dominant osteodystrophy type II (ADO2) is an inherited disease characterized by an abnormal increase in bone mineral density, and CLCN7 (R286W) is its most common causative mutation.
Jiajun Xu, Gengshuo Chen, Chune Mo, Yu Sha, Sha Luo, Minglin Ou   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2

BMC Biology
Background Heterozygous mutation of CLCN7 (R286W) is commonly found in patients with benign autosomal dominant osteopetrosis. However, there is no evidence from animal models to confirm that it is a disease mutation.
Yu Sha, Lingyu Huang, Lei Zhang, Xianliang Hou, Chune Mo, Cuiping Pan, Gengshuo Chen, Sha Luo, Minglin Ou   +8 more
doaj   +1 more source