Results 41 to 50 of about 124,650 (265)

Research progress on the effect of metabolic reprogramming on macrophage polarization [PDF]

Journal of Hebei University of Science and Technology
The pathogenesis of inflammatory diseases involves complex cellular cascades within tissues, where macrophages play a pivotal role. These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of ...
Jiangtao SHAO, Junyu QI, Zexu HAN, Xueling GUO, Yike QI, Yingze WANG   +5 more
doaj   +1 more source

Metabolic Reprogramming in Dietary Restriction [PDF]

, 2006
It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed.
Rozalyn M, Anderson, Richard, Weindruch
openaire   +2 more sources

Metabolic reprogramming in efferocytosis

Frontiers in Cell and Developmental Biology
Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair.
Yan, Qing, Li, Kuo, Chen, Lu, Wang, Aowei, Xi, Yingying, Xiao, Hui, Yuan, Lei   +6 more
openaire   +3 more sources

Metabolic reprogramming of pulmonary fibrosis

Frontiers in Pharmacology, 2022
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that affects alveoli elasticity, which leading to higher rates of hospitalization and mortality worldwide. Pulmonary fibrosis is initiated by repetitive localized micro-damages of the alveolar epithelium, which subsequently triggers aberrant epithelial-fibroblast ...
Jiaxin Li, Jiaxin Li, Jiaxin Li, Jiaxin Li, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiao Sun, Xiao Sun, Xiao Sun, Xiao Sun, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Jiali Wang, Jiali Wang, Jiali Wang, Jiali Wang   +23 more
openaire   +3 more sources

MYCN and Metabolic Reprogramming in Neuroblastoma

Cancers, 2022
Neuroblastoma is a pediatric cancer responsible for approximately 15% of all childhood cancer deaths. Aberrant MYCN activation, as a result of genomic MYCN amplification, is a major driver of high-risk neuroblastoma, which has an overall survival rate of less than 50%, despite the best treatments currently available.
Mohit Bansal, Anamika Gupta, Han-Fei Ding   +2 more
openaire   +2 more sources

Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis

Metabolites, 2021
Cancer cells face various metabolic challenges during tumor progression, including growth in the nutrient-altered and oxygen-deficient microenvironment of the primary site, intravasation into vessels where anchorage-independent growth is required, and ...
Kenji Ohshima, Eiichi Morii
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

The role of programmed cell death 1 in autoimmune diseases: mechanisms and therapeutic implications

Frontiers in Immunology
Autoimmune diseases are complex disorders caused by the interaction between the immune system and self-antigens, involving genetic, environmental triggers, and other cellular factors. The programmed cell death receptor-1 (PD-1) gene, as a critical factor
Zhenyu Liu, Zhenyu Liu, Zipeng Hu, Huilin Lao, Lemin Chen, Yue Wen, Yuqiang Liang, Chong Zhang, Jiang Wu, Xianliang Hou, Xianliang Hou   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Metabolic reprogramming in osteoclasts

Seminars in Immunopathology, 2019
Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of the bone. Defects in osteoclasts thus result in unbalanced bone remodeling, leading to numerous pathological conditions such as osteoporosis, bone metastasis, and inflammatory bone erosion.
openaire   +3 more sources