Results 41 to 50 of about 192,395 (356)

Research progress of microRNAs as remodelers of lipid metabolic reprogramming in hepatocellular carcinoma [PDF]

Jichu yixue yu linchuang, 2022
Metabolic reprogramming is considered to be one of the top characteristics of tumor cells. Ample experimental studies have shown that microRNAs, which are a group of multifunctional non-coding RNAs, play an important role in the development of ...
WANG Yu-min, CHEN Ji-chao, WANG Hong-quan, WANG Jin-hua, TANG Bo
doaj   +1 more source

Metabolic Reprogramming in Dietary Restriction [PDF]

, 2006
It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed.
Rozalyn M, Anderson, Richard, Weindruch
openaire   +2 more sources

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [PDF]

, 2018
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles.
O\u27Keefe, Regis J, Shen, Jie, Silverman, Richard M, Wang, Cuicui   +3 more
core   +3 more sources

Metabolic reprogramming during neuronal differentiation [PDF]

Cell Death & Differentiation, 2016
Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic neurons undergo neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity.
Agostini M., Romeo F., Inoue S., Niklison-Chirou M. V., Elia A. J., Dinsdale D., Morone N., Knight R. A., Mak T. W., Melino G.   +9 more
openaire   +3 more sources

Metabolic reprogramming in efferocytosis. [PDF]

Front Cell Dev Biol
Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair.
Yan Q, Li K, Chen L, Wang A, Xi Y, Xiao H, Yuan L.   +6 more
europepmc   +3 more sources

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis

Metabolites, 2021
Cancer cells face various metabolic challenges during tumor progression, including growth in the nutrient-altered and oxygen-deficient microenvironment of the primary site, intravasation into vessels where anchorage-independent growth is required, and ...
Kenji Ohshima, Eiichi Morii
doaj   +1 more source

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source

Targeting cancer cell metabolism in pancreatic adenocarcinoma. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent need to explore innovative treatment strategies.
Cohen, R., de Gramont, A., Faivre, S., Neuzillet, C., Raymond, E., Tijeras-Raballand, A.   +5 more
core   +2 more sources

Metabolic Reprogramming Promotes Myogenesis During Aging [PDF]

Frontiers in Physiology, 2019
Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging.
Roberta Belli, Agnese Bonato, Luciana De Angelis, Simone Mirabilii, Maria Rosaria Ricciardi, Agostino Tafuri, Alessio Molfino, Massimiliano Leigheb, Paola Costelli, Maurizia Caruso, Maurizio Muscaritoli, Elisabetta Ferraro, Elisabetta Ferraro   +12 more
openaire   +6 more sources