Results 41 to 50 of about 1,077,952 (298)
, 2022 Irreversible pancreatic β-cell damage may be a result of chronic exposure to supraphysiological glucose or lipid concentrations or chronic exposure to therapeutic anti-diabetic drugs.
Cruzat, Vinicius +7 more
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Energy Metabolism in Nuclear Reprogramming [PDF]
Biomarkers in Medicine, 2011 Nuclear reprogramming with stemness factors enables resetting of somatic differentiated tissue back to the pluripotent ground state. Recent evidence implicates mitochondrial restructuring and bioenergetic plasticity as key components underlying execution of orchestrated dedifferentiation and derivation of induced pluripotent stem cells.
Clifford D L, Folmes +2 more
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Editorial: Metabolic reprogramming in breast cancer [PDF]
, 2022 Metabolic reprogramming is an emerging hallmark of breast cancer. A common characteristic of tumor cells is the ability to obtain nutrients from a nutrient-deprived environment and to use them to sustain cancer progression, within crucial metabolic ...
Scumaci, D +7 more
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Metabolic reprogramming of pulmonary fibrosis
Frontiers in Pharmacology, 2022 Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that affects alveoli elasticity, which leading to higher rates of hospitalization and mortality worldwide. Pulmonary fibrosis is initiated by repetitive localized micro-damages of the alveolar epithelium, which subsequently triggers aberrant epithelial-fibroblast ...
Jiaxin Li +23 more
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Metabolic Reprogramming in Dietary Restriction [PDF]
, 2006 It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed.
Rozalyn M, Anderson, Richard, Weindruch
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Metabolic reprogramming under microaerobic and anaerobic conditions in bacteria
, 2012 Oxygen has a great impact on the metabolism and physiology of microorganisms. It serves as the most efficient terminal electron acceptor to drive the energy conservation process of cellular respiration and is required in many biosynthetic reactions ...
Yan, Aixin +8 more
core +1 more source
Research progress on the effect of metabolic reprogramming on macrophage polarization [PDF]
Journal of Hebei University of Science and TechnologyThe pathogenesis of inflammatory diseases involves complex cellular cascades within tissues, where macrophages play a pivotal role. These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of ...
Jiangtao SHAO +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 It is notorious that cancer cells alter their metabolism to adjust to harsh environments of hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor microenvironment (TME).
Yifei Zhu +4 more
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Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
, 2021 Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of ...
Jun Zhang +4 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source