Results 51 to 60 of about 123,701 (265)

Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment

Journal of Experimental & Clinical Cancer Research, 2023
Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet their growth requirements.
Shiming Tan, Yiqing Yang, Wenjuan Yang, Yaqian Han, Lisheng Huang, Ruiqian Yang, Zifan Hu, Yi Tao, Lin Liu, Yun Li, Linda Oyang, Jinguan Lin, Qiu Peng, Xianjie Jiang, Xuemeng Xu, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Deliang Cao, Qianjin Liao, Yujuan Zhou   +21 more
doaj   +1 more source

Metabolism in Cancer Stem Cells: Targets for Clinical Treatment

Cells, 2022
Cancer stem cells (CSCs) have high tumorigenicity, high metastasis and high resistance to treatment. They are the key factors for the growth, metastasis and drug resistance of malignant tumors, and are also the important reason for the occurrence and ...
Gui-Min Wen, Xiao-Yan Xu, Pu Xia
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Immune-metabolic crosstalk in HNSCC: mechanisms and therapeutic opportunities

Frontiers in Oncology
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy, characterized by metabolic reprogramming. This reprogramming creates an acidic and hypoxic environment within tumor cells to adapt to metabolic changes.
Xiyuan Qin, Hui Wu, Jiaqi Pan, Kai Kang, Yujie Shi, Shoushan Bu   +5 more
doaj   +1 more source

O-GlcNAcylation and Metabolic Reprograming in Cancer [PDF]

Frontiers in Endocrinology, 2014
Although cancer metabolism has received considerable attention over the past decade, our knowledge on its specifics is still fragmentary. Altered cellular metabolism is one of the most important hallmarks of cancer. Cancer cells exhibit aberrant glucose metabolism characterized by aerobic glycolysis, a phenomenon known as Warburg effect.
Jóźwiak, Paweł, Forma, Ewa, Bryś, Magdalena, Krześlak, Anna   +3 more
openaire   +5 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host

Gut Microbes
Metabolic diseases pose a major global health challenge, the pathogenesis of which centers on “metabolic reprogramming”; that is, the adaptive or pathological rewiring of metabolic pathways.
Yanrong Wang, Beibei Huang, Xue Wei, Yuanyuan Guan, Lingru Li, Yanfei Zheng, Wenlong Sun   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Emerging Landscapes of Tumor Immunity and Metabolism

Frontiers in Oncology, 2020
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor ...
Fan Wu, Ye Cheng, Liangliang Wu, Wenling Zhang, Wubing Zheng, Qian Wang, Hongyong Cao, Xiongxiong Pan, Weiwei Tang   +8 more
doaj   +1 more source

Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease

Frontiers in Immunology, 2023
Mitochondria has emerged as a critical ruler of metabolic reprogramming in immune responses and inflammation. In the context of colitogenic T cells and IBD, there has been increasing research interest in the metabolic pathways of glycolysis, pyruvate ...
Hoyul Lee, Jae-Han Jeon, Jae-Han Jeon, Eun Soo Kim   +3 more
doaj   +1 more source