Results 51 to 60 of about 124,650 (265)

Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace

Discover Oncology
Objective Tumor-derived exosomes testing can be effective in diagnosing disease and assisting in the treatment of disease. Our study utilizes bibliometric analysis to identify research hotspots related to tumor-derived exosomes, predict emerging research
Ruijun Guo, Jiajun Xu, Chunxia Li, Chune Mo, Minglin Ou   +4 more
doaj   +1 more source

Construction of a Dataset for All Expressed Transcripts for Alzheimer’s Disease Research

Brain Sciences
Accurate identification and functional annotation of splicing isoforms and non-coding RNAs (lncRNAs), alongside full-length protein-encoding transcripts, are critical for understanding gene (mis)regulation and metabolic reprogramming in Alzheimer’s ...
Zhenyu Huang, Bocheng Shi, Xuechen Mu, Siyu Qiao, Gangyi Xiao, Yan Wang, Ying Xu   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Transcriptomic and proteomic analysis of osteogenesis imperfecta disease-specific induced pluripotent stem cells

BMC Medical Genomics
Background Osteogenesis imperfecta (OI) is a rare genetic bone disorder for which treatment options remain limited. Disease-specific induced pluripotent stem cells (iPSCs) offer a valuable model to investigate its underlying pathological mechanisms ...
Ruijun Guo, Lingyu Huang, Yu Sha, Chune Mo, Chunhong Li, Weiwei Gong, Xianliang Hou, Minglin Ou   +7 more
doaj   +1 more source

Clinical applications and challenges of CD40/CD40L signaling regulation in autoimmune diseases

Frontiers in Immunology
The CD40–CD40L axis is a central costimulatory pathway that links innate and adaptive immunity and contributes to autoimmune inflammation. However, CD40 signaling does not operate in the same way across cell types, and these differences are relevant to ...
Yangyang Man, Xiaoni Chen, Yi Liu, Biao Zhang, Jiahua Hu, Xianliang Hou, Xianliang Hou   +6 more
doaj   +1 more source

The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer

Frontiers in Pharmacology, 2021
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC.
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system

Stem Cell Research & Therapy
Background Autosomal dominant osteodystrophy type II (ADO2) is an inherited disease characterized by an abnormal increase in bone mineral density, and CLCN7 (R286W) is its most common causative mutation.
Jiajun Xu, Gengshuo Chen, Chune Mo, Yu Sha, Sha Luo, Minglin Ou   +5 more
doaj   +1 more source

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming

Stem Cell Reports, 2018
Summary: Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood.
Javier Prieto, Arnold Y. Seo, Marian León, Fulvio Santacatterina, Laura Torresano, Martina Palomino-Schätzlein, Karen Giménez, Azahara Vallet-Sánchez, Xavier Ponsoda, Antonio Pineda-Lucena, José M. Cuezva, Jennifer Lippincott-Schwartz, Josema Torres   +12 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source