Results 51 to 60 of about 1,077,952 (298)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Metabolic reprogramming in osteoclasts

Seminars in Immunopathology, 2019
Osteoclasts are bone-resorbing cells that play an essential role in the remodeling of the bone. Defects in osteoclasts thus result in unbalanced bone remodeling, leading to numerous pathological conditions such as osteoporosis, bone metastasis, and inflammatory bone erosion.
openaire   +3 more sources

Visualizing and analyzing global knowledge maps and emerging research trends in tumor-derived exosomes using CiteSpace

Discover Oncology
Objective Tumor-derived exosomes testing can be effective in diagnosing disease and assisting in the treatment of disease. Our study utilizes bibliometric analysis to identify research hotspots related to tumor-derived exosomes, predict emerging research
Ruijun Guo, Jiajun Xu, Chunxia Li, Chune Mo, Minglin Ou   +4 more
doaj   +1 more source

The role of programmed cell death 1 in autoimmune diseases: mechanisms and therapeutic implications

Frontiers in Immunology
Autoimmune diseases are complex disorders caused by the interaction between the immune system and self-antigens, involving genetic, environmental triggers, and other cellular factors. The programmed cell death receptor-1 (PD-1) gene, as a critical factor
Zhenyu Liu, Zhenyu Liu, Zipeng Hu, Huilin Lao, Lemin Chen, Yue Wen, Yuqiang Liang, Chong Zhang, Jiang Wu, Xianliang Hou, Xianliang Hou   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transcriptomic and proteomic analysis of osteogenesis imperfecta disease-specific induced pluripotent stem cells

BMC Medical Genomics
Background Osteogenesis imperfecta (OI) is a rare genetic bone disorder for which treatment options remain limited. Disease-specific induced pluripotent stem cells (iPSCs) offer a valuable model to investigate its underlying pathological mechanisms ...
Ruijun Guo, Lingyu Huang, Yu Sha, Chune Mo, Chunhong Li, Weiwei Gong, Xianliang Hou, Minglin Ou   +7 more
doaj   +1 more source

PD-1 deficiency reshapes the TCRβ repertoire and T-cell developmental programs associated with susceptibility to lupus-like autoimmunity

Frontiers in Immunology
IntroductionProgrammed cell death protein-1 (PD-1) functions as a pivotal immune checkpoint, essential for maintaining peripheral immune tolerance, and serves as a significant therapeutic target in cancer immunotherapy.
Xianliang Hou, Xianliang Hou, Zhenyu Liu, Guiya Lu, Shaofeng Jiang, Jinjun Qiu, Chunhong Li, Meng Meng, Zipeng Hu, Yinping Lei, Huilin Lao, Lemin Chen, Yue Wen, Siyan Xie, Yuqiang Liang   +14 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Development and evaluation of siRNA-mediated gene silencing strategies for ADO2 therapy utilizing iPSCs model and DMPC-SPIONs delivery system

Stem Cell Research & Therapy
Background Autosomal dominant osteodystrophy type II (ADO2) is an inherited disease characterized by an abnormal increase in bone mineral density, and CLCN7 (R286W) is its most common causative mutation.
Jiajun Xu, Gengshuo Chen, Chune Mo, Yu Sha, Sha Luo, Minglin Ou   +5 more
doaj   +1 more source

Construction of a Dataset for All Expressed Transcripts for Alzheimer’s Disease Research

Brain Sciences
Accurate identification and functional annotation of splicing isoforms and non-coding RNAs (lncRNAs), alongside full-length protein-encoding transcripts, are critical for understanding gene (mis)regulation and metabolic reprogramming in Alzheimer’s ...
Zhenyu Huang, Bocheng Shi, Xuechen Mu, Siyu Qiao, Gangyi Xiao, Yan Wang, Ying Xu   +6 more
doaj   +1 more source