Results 31 to 40 of about 1,077,952 (298)
Metabolic Reprogramming in Thyroid Carcinoma [PDF]
Frontiers in Oncology, 2018 Among all the adaptations of cancer cells, their ability to change metabolism from the oxidative to the glycolytic phenotype is a hallmark called the Warburg effect. Studies on tumor metabolism show that improved glycolysis and glutaminolysis are necessary to maintain rapid cell proliferation, tumor progression, and resistance to cell death.
Raquel Guimaraes Coelho +2 more
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Natural products modulate renal metabolic reprogramming in diabetic kidney disease. [PDF]
J Transl Int MedDiabetic kidney disease (DKD) is a major cause of end-stage renal disease worldwide. Its pathogenesis is highly complex and involves dysfunction across multiple renal cell types and metabolic pathways, thereby underscoring the urgent need for novel ...
Wang W +8 more
europepmc +2 more sources
HIF1α and metabolic reprogramming in inflammation [PDF]
Journal of Clinical Investigation, 2016 HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the ...
Sarah E, Corcoran, Luke A J, O'Neill
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Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success [PDF]
, 2012 Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage.
Franchesca Dawn Houghton (171722) +44 more
core +2 more sources
Metabolic Reprogramming and Vulnerabilities in Cancer [PDF]
Cancers, 2019 Metabolic programs are rewired in tumors to support growth, progression, and immune evasion. A wealth of work in the past decade has delineated how these metabolic rearrangements are facilitated by signaling pathways downstream of oncogene activation and tumor suppressor loss.
Lyssiotis, Costas A., Nagrath, Deepak
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Metabolic reprogramming and cancer progression [PDF]
Science, 2020 Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al. discuss how metabolism changes as cancer develops from a small, premalignant lesion to an aggressive primary
Brandon Faubert +2 more
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Investigating metabolic reprogramming in adipocytes via 13C-based techniques
, 2020 Antoniewicz, Maciek R.Metabolic disorders such as type II diabetes and obesity are some of the greatest health challenges facing our world today. Although several genetic, lifestyle, and environmental risk factors contribute to the pathogenesis of these ...
Oates, Eleanor Hammer
core +1 more source
Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]
, 2011 Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco +13 more
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Evolutionary Origins of Metabolic Reprogramming in Cancer [PDF]
International Journal of Molecular Sciences, 2022 Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. These changes are not specific to tumors but also take place during the physiological growth of tissues. Indeed, the cellular and tissue mechanisms present in the tumor have their physiological counterpart in the repair of tissue lesions and wound healing.
Natalia García-Sancha +11 more
openaire +6 more sources
Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming [PDF]
, 2011 Cancer is a disorder with various genetic and epigenetic alterations. Genetic alterations such as mutations, i.e., substitutions, amplifications, and deletions of nucleotide sequences, are largely irreversible, whereas epigenetic alterations can be ...
Kazuyoshi Yamamoto +8 more
core +1 more source