Results 31 to 40 of about 124,650 (265)
Metabolic Reprogramming and Vulnerabilities in Cancer [PDF]
Cancers, 2019 Metabolic programs are rewired in tumors to support growth, progression, and immune evasion. A wealth of work in the past decade has delineated how these metabolic rearrangements are facilitated by signaling pathways downstream of oncogene activation and tumor suppressor loss.
Lyssiotis, Costas A., Nagrath, Deepak
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International Journal of Hyperthermia, 2023 Cellular metabolic reprogramming is an important feature of malignant tumors. Metabolic reprogramming causes changes in the levels or types of specific metabolites inside and outside the cell, which affects tumorigenesis and progression by influencing ...
Yuchuan Yang +3 more
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Metabolic Reprogramming in Health and Disease [PDF]
International Journal of Molecular Sciences, 2020 This editorial aims to summarize the six scientific papers that contributed to this Special Issue.
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Metabolic Reprogramming in Thyroid Carcinoma [PDF]
Frontiers in Oncology, 2018 Among all the adaptations of cancer cells, their ability to change metabolism from the oxidative to the glycolytic phenotype is a hallmark called the Warburg effect. Studies on tumor metabolism show that improved glycolysis and glutaminolysis are necessary to maintain rapid cell proliferation, tumor progression, and resistance to cell death.
Raquel Guimaraes Coelho +2 more
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Evolutionary Origins of Metabolic Reprogramming in Cancer [PDF]
International Journal of Molecular Sciences, 2022 Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. These changes are not specific to tumors but also take place during the physiological growth of tissues. Indeed, the cellular and tissue mechanisms present in the tumor have their physiological counterpart in the repair of tissue lesions and wound healing.
Natalia García-Sancha +11 more
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HIF1α and metabolic reprogramming in inflammation [PDF]
Journal of Clinical Investigation, 2016 HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the ...
Sarah E, Corcoran, Luke A J, O'Neill
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Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease
Frontiers in Immunology, 2022 Macrophages are highly plastic cells, and the polarization-activating actions that represent their functional focus are closely related to metabolic reprogramming.
Xiaoqian Sun +12 more
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Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases
Redox Biology, 2023 Oxygen therapy is common during the neonatal period to improve survival, but it can increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in newborns, commonly causing lung conditions such as bronchopulmonary dysplasia ...
Tong Sun +4 more
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Frontiers in Endocrinology, 2022 It is notorious that cancer cells alter their metabolism to adjust to harsh environments of hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor microenvironment (TME).
Yifei Zhu +4 more
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Energy Metabolism in Nuclear Reprogramming [PDF]
Biomarkers in Medicine, 2011 Nuclear reprogramming with stemness factors enables resetting of somatic differentiated tissue back to the pluripotent ground state. Recent evidence implicates mitochondrial restructuring and bioenergetic plasticity as key components underlying execution of orchestrated dedifferentiation and derivation of induced pluripotent stem cells.
Clifford D L, Folmes +2 more
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