Results 31 to 40 of about 123,701 (265)

Energy Metabolism in Nuclear Reprogramming [PDF]

Biomarkers in Medicine, 2011
Nuclear reprogramming with stemness factors enables resetting of somatic differentiated tissue back to the pluripotent ground state. Recent evidence implicates mitochondrial restructuring and bioenergetic plasticity as key components underlying execution of orchestrated dedifferentiation and derivation of induced pluripotent stem cells.
Clifford D L, Folmes, Timothy J, Nelson, Andre, Terzic   +2 more
openaire   +2 more sources

Research progress on the effect of metabolic reprogramming on macrophage polarization [PDF]

Journal of Hebei University of Science and Technology
The pathogenesis of inflammatory diseases involves complex cellular cascades within tissues, where macrophages play a pivotal role. These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of ...
Jiangtao SHAO, Junyu QI, Zexu HAN, Xueling GUO, Yike QI, Yingze WANG   +5 more
doaj   +1 more source

Metabolic Reprogramming in Dietary Restriction [PDF]

, 2006
It is widely accepted that energy intake restriction without essential nutrient deficiency delays the onset of aging and extends life span. The mechanism underlying this phenomenon is still unknown though a number of different, nonmutually exclusive explanations have been proposed.
Rozalyn M, Anderson, Richard, Weindruch
openaire   +2 more sources

Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis

Metabolites, 2021
Cancer cells face various metabolic challenges during tumor progression, including growth in the nutrient-altered and oxygen-deficient microenvironment of the primary site, intravasation into vessels where anchorage-independent growth is required, and ...
Kenji Ohshima, Eiichi Morii
doaj   +1 more source

Metabolic reprogramming of pulmonary fibrosis

Frontiers in Pharmacology, 2022
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that affects alveoli elasticity, which leading to higher rates of hospitalization and mortality worldwide. Pulmonary fibrosis is initiated by repetitive localized micro-damages of the alveolar epithelium, which subsequently triggers aberrant epithelial-fibroblast ...
Jiaxin Li, Jiaxin Li, Jiaxin Li, Jiaxin Li, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiao Sun, Xiao Sun, Xiao Sun, Xiao Sun, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Jiali Wang, Jiali Wang, Jiali Wang, Jiali Wang   +23 more
openaire   +3 more sources

MYCN and Metabolic Reprogramming in Neuroblastoma

Cancers, 2022
Neuroblastoma is a pediatric cancer responsible for approximately 15% of all childhood cancer deaths. Aberrant MYCN activation, as a result of genomic MYCN amplification, is a major driver of high-risk neuroblastoma, which has an overall survival rate of less than 50%, despite the best treatments currently available.
Mohit Bansal, Anamika Gupta, Han-Fei Ding   +2 more
openaire   +2 more sources

The role of programmed cell death 1 in autoimmune diseases: mechanisms and therapeutic implications

Frontiers in Immunology
Autoimmune diseases are complex disorders caused by the interaction between the immune system and self-antigens, involving genetic, environmental triggers, and other cellular factors. The programmed cell death receptor-1 (PD-1) gene, as a critical factor
Zhenyu Liu, Zhenyu Liu, Zipeng Hu, Huilin Lao, Lemin Chen, Yue Wen, Yuqiang Liang, Chong Zhang, Jiang Wu, Xianliang Hou, Xianliang Hou   +10 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Construction of a Dataset for All Expressed Transcripts for Alzheimer’s Disease Research

Brain Sciences
Accurate identification and functional annotation of splicing isoforms and non-coding RNAs (lncRNAs), alongside full-length protein-encoding transcripts, are critical for understanding gene (mis)regulation and metabolic reprogramming in Alzheimer’s ...
Zhenyu Huang, Bocheng Shi, Xuechen Mu, Siyu Qiao, Gangyi Xiao, Yan Wang, Ying Xu   +6 more
doaj   +1 more source

The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer

Frontiers in Pharmacology, 2021
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC.
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu   +3 more
doaj   +1 more source