Results 21 to 30 of about 124,650 (265)
Metabolic Reprogramming in Glioma [PDF]
Frontiers in Cell and Developmental Biology, 2017 Many cancers have long been thought to primarily metabolize glucose for energy production-a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the early twentieth century. Yet cancer cells also utilize other substrates, such as amino acids and fatty acids, to produce raw materials for cellular maintenance and energetic
Strickland, Marie, Stoll, Elizabeth A.
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Metabolic reprogramming in macrophage responses [PDF]
Biomarker Research, 2021 AbstractMacrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment and play an important role in tumor initiation, growth, invasion, and metastasis.
Yang Liu +9 more
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Metabolic Reprograming in Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes ...
Silvia Galván-Peña +1 more
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Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
Viruses, 2022 Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for large-scale biosynthesis. Based on studies of the cellular changes that contribute to
Charles N. S. Allen +3 more
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BMC Medical Genomics, 2023 Background Colorectal cancer is a malignant tumor that poses a serious threat to human health. The main objective of this study is to investigate the mechanism by which Jatrorrhizine (JAT), a root extract from Stephania Epigaea Lo, exerts its anticancer ...
Lingyu Huang +8 more
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Frontiers in Oncology, 2022 Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells.
Shushan Yan +8 more
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Metabolic Reprogramming in Kidney Diseases: Evidence and Therapeutic Opportunities
International Journal of Nephrology, 2021 Metabolic reprogramming originally referred to the ability of cancer cells to metabolically adapt to changes in environmental conditions to meet both energy consumption and proliferation requirements.
Yin Li, Zixin Sha, Hui Peng
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Metabolic Reprogramming and Renal Fibrosis [PDF]
Frontiers in Medicine, 2021 There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to ...
Xiaoyu Zhu +5 more
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Metabolic reprogramming and cancer progression [PDF]
Science, 2020 Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al. discuss how metabolism changes as cancer develops from a small, premalignant lesion to an aggressive primary
Brandon Faubert +2 more
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Cancer & Metabolism, 2019 Background Increased flux through both glycolytic and oxidative metabolic pathways is a hallmark of breast cancer cells and is critical for their growth and survival.
Sheree D. Martin, Sean L. McGee
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