Results 21 to 30 of about 1,077,952 (298)

Metabolic Reprogramming of Liver Fibrosis [PDF]

Cells, 2021
Liver fibrosis is an excessive and imbalanced deposition of fibrous extracellular matrix (ECM) that is associated with the hepatic wound-healing response. It is also the common mechanism that contributes to the impairment of the liver function that is observed in many chronic liver diseases (CLD).
M. Eugenia Delgado, Beatriz I. Cárdenas, Núria Farran, Mercedes Fernandez   +3 more
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Metabolic reprogramming in prostate cancer [PDF]

British Journal of Cancer, 2021
AbstractAlthough low risk localised prostate cancer has an excellent prognosis owing to effective treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic prostate cancer remains incurable. Existing therapeutic regimens prolong life; however, they are beset by problems of resistance, resulting in poor outcomes.
Fahim Ahmad, Murali Krishna Cherukuri, Peter L. Choyke   +2 more
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Metabolic reprogramming of the tumor [PDF]

Oncogene, 2012
Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology.
Ferreira, LM, Hebrant, Aline, Dumont, Jacques Emile   +2 more
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Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis [PDF]

, 2023
Plants are sessile and therefore have developed an extraordinary capacity to adapt to external signals. Here, the focus is on the plasticity of the plant cell to respond to new intracellular cues.
Nogueira, M., Lewinsohn, E., Price, E. J., Fraser, P. D., Menard, G. N., Eastmond, P. J., Venter, E., Bar, E., Enfissi, E. M. A.   +8 more
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Immune cell metabolism and metabolic reprogramming

Molecular Biology Reports, 2022
Energy metabolism maintains the activation of intracellular and intercellular signal transduction, and plays a crucial role in immune response. Under environmental stimulation, immune cells change from resting to activation and trigger metabolic reprogramming. The immune system cells exhibit different metabolic characteristics when performing functions.
Chenchen Hu, Yuxin Xuan, Xiyang Zhang, Yang Liu, Shuya Yang, Kun Yang   +5 more
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Metabolic Reprogramming in Glioma [PDF]

Frontiers in Cell and Developmental Biology, 2017
Many cancers have long been thought to primarily metabolize glucose for energy production-a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the early twentieth century. Yet cancer cells also utilize other substrates, such as amino acids and fatty acids, to produce raw materials for cellular maintenance and energetic
Strickland, Marie, Stoll, Elizabeth A.
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Metabolic Reprograming in Macrophage Polarization [PDF]

Frontiers in Immunology, 2014
Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes ...
Silvia Galván-Peña, Luke A. J. O’Neill   +1 more
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Metabolic reprogramming in macrophage responses [PDF]

Biomarker Research, 2021
AbstractMacrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment and play an important role in tumor initiation, growth, invasion, and metastasis.
Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai   +9 more
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Metabolic Reprogramming and Renal Fibrosis [PDF]

Frontiers in Medicine, 2021
There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to ...
Xiaoyu Zhu, Lili Jiang, Mengtuan Long, Xuejiao Wei, Yue Hou, Yujun Du   +5 more
openaire   +3 more sources

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]

, 2014
The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
Benoit Viollet, David K. Finlay, Doreen A. Cantrell, Finlay David K., Viollet, Benoit, Marc Foretz, Cantrell, Doreen A., Viollet Benoit, FINLAY, DAVID, Marouan Zarrouk, Zarrouk, Marouan, David K Finlay, Doreen A Cantrell, Zarrouk Marouan, Foretz, Marc, Foretz Marc, Cantrell Doreen A., Finlay, David K.   +17 more
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