Results 21 to 30 of about 123,701 (265)
Metabolic Reprograming in Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes ...
Silvia Galván-Peña +1 more
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Metabolic Reprogramming is a Hallmark of Metabolism Itself [PDF]
BioEssays, 2020 AbstractThe reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic reprogramming is not driven by disease but instead is the main hallmark of metabolism, based on its dynamic behavior that ...
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Metabolic Reprogramming and Renal Fibrosis [PDF]
Frontiers in Medicine, 2021 There are several causes of chronic kidney disease, but all of these patients have renal fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are still no effective treatments. A healthy and balanced metabolism is necessary for normal cell growth, proliferation, and function, but metabolic abnormalities can lead to ...
Xiaoyu Zhu +5 more
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Metabolic reprogramming and cancer progression [PDF]
Science, 2020 Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al. discuss how metabolism changes as cancer develops from a small, premalignant lesion to an aggressive primary
Brandon Faubert +2 more
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Metabolic Reprogramming and Vulnerabilities in Cancer [PDF]
Cancers, 2019 Metabolic programs are rewired in tumors to support growth, progression, and immune evasion. A wealth of work in the past decade has delineated how these metabolic rearrangements are facilitated by signaling pathways downstream of oncogene activation and tumor suppressor loss.
Lyssiotis, Costas A., Nagrath, Deepak
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Metabolic Reprogramming in Health and Disease [PDF]
International Journal of Molecular Sciences, 2020 This editorial aims to summarize the six scientific papers that contributed to this Special Issue.
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Metabolic Reprogramming in Thyroid Carcinoma [PDF]
Frontiers in Oncology, 2018 Among all the adaptations of cancer cells, their ability to change metabolism from the oxidative to the glycolytic phenotype is a hallmark called the Warburg effect. Studies on tumor metabolism show that improved glycolysis and glutaminolysis are necessary to maintain rapid cell proliferation, tumor progression, and resistance to cell death.
Raquel Guimaraes Coelho +2 more
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Evolutionary Origins of Metabolic Reprogramming in Cancer [PDF]
International Journal of Molecular Sciences, 2022 Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. These changes are not specific to tumors but also take place during the physiological growth of tissues. Indeed, the cellular and tissue mechanisms present in the tumor have their physiological counterpart in the repair of tissue lesions and wound healing.
Natalia García-Sancha +11 more
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HIF1α and metabolic reprogramming in inflammation [PDF]
Journal of Clinical Investigation, 2016 HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the ...
Sarah E, Corcoran, Luke A J, O'Neill
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Frontiers in Endocrinology, 2022 It is notorious that cancer cells alter their metabolism to adjust to harsh environments of hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor microenvironment (TME).
Yifei Zhu +4 more
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