Results 21 to 30 of about 109,926 (267)

Metabolic reprogramming and cancer progression [PDF]

Science, 2020
Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al. discuss how metabolism changes as cancer develops from a small, premalignant lesion to an aggressive primary
Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis   +2 more
openaire   +2 more sources

Metabolic Reprogramming in Thyroid Carcinoma [PDF]

Frontiers in Oncology, 2018
Among all the adaptations of cancer cells, their ability to change metabolism from the oxidative to the glycolytic phenotype is a hallmark called the Warburg effect. Studies on tumor metabolism show that improved glycolysis and glutaminolysis are necessary to maintain rapid cell proliferation, tumor progression, and resistance to cell death.
Raquel Guimaraes Coelho, Rodrigo S. Fortunato, Denise P. Carvalho   +2 more
openaire   +3 more sources

Metabolic reprogramming of the tumor [PDF]

Oncogene, 2012
Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology.
Ferreira, LM, Hebrant, Aline, Dumont, Jacques Emile   +2 more
openaire   +3 more sources

Metabolic reprogramming in efferocytosis. [PDF]

Front Cell Dev Biol
Efferocytosis refers to the process by which phagocytes specifically identify and eliminate apoptotic cells. This process is essential for both maintaining tissue homeostasis and suppressing inflammatory responses, as well as facilitating tissue repair.
Yan Q, Li K, Chen L, Wang A, Xi Y, Xiao H, Yuan L.   +6 more
europepmc   +3 more sources

Energy Metabolism in Nuclear Reprogramming [PDF]

Biomarkers in Medicine, 2011
Nuclear reprogramming with stemness factors enables resetting of somatic differentiated tissue back to the pluripotent ground state. Recent evidence implicates mitochondrial restructuring and bioenergetic plasticity as key components underlying execution of orchestrated dedifferentiation and derivation of induced pluripotent stem cells.
Clifford D L, Folmes, Timothy J, Nelson, Andre, Terzic   +2 more
openaire   +2 more sources

Metabolic reprogramming of pulmonary fibrosis

Frontiers in Pharmacology, 2022
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that affects alveoli elasticity, which leading to higher rates of hospitalization and mortality worldwide. Pulmonary fibrosis is initiated by repetitive localized micro-damages of the alveolar epithelium, which subsequently triggers aberrant epithelial-fibroblast ...
Jiaxin Li, Jiaxin Li, Jiaxin Li, Jiaxin Li, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiaoxuan Zhai, Xiao Sun, Xiao Sun, Xiao Sun, Xiao Sun, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Shengchuan Cao, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Qiuhuan Yuan, Jiali Wang, Jiali Wang, Jiali Wang, Jiali Wang   +23 more
openaire   +3 more sources

Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment

Frontiers in Endocrinology, 2022
It is notorious that cancer cells alter their metabolism to adjust to harsh environments of hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor microenvironment (TME).
Yifei Zhu, Xinyan Li, Lei Wang, Xiwei Hong, Jie Yang   +4 more
doaj   +1 more source

Metabolic reprogramming in the arsenic carcinogenesis

Ecotoxicology and Environmental Safety, 2022
Chronic exposure to arsenic has been associated with a variety of cancers with the mechanisms undefined. Arsenic exposure causes alterations in metabolites in bio-samples.
Yihui Ruan, Xin Fang, Tingyue Guo, Yiting Liu, Yu Hu, Xuening Wang, Yuxin Hu, Lanyue Gao, Yongfang Li, Jingbo Pi, Yuanyuan Xu   +10 more
doaj   +1 more source

Research progress of microRNAs as remodelers of lipid metabolic reprogramming in hepatocellular carcinoma [PDF]

Jichu yixue yu linchuang, 2022
Metabolic reprogramming is considered to be one of the top characteristics of tumor cells. Ample experimental studies have shown that microRNAs, which are a group of multifunctional non-coding RNAs, play an important role in the development of ...
WANG Yu-min, CHEN Ji-chao, WANG Hong-quan, WANG Jin-hua, TANG Bo
doaj   +1 more source

Research progress on the effect of metabolic reprogramming on macrophage polarization [PDF]

Journal of Hebei University of Science and Technology
The pathogenesis of inflammatory diseases involves complex cellular cascades within tissues, where macrophages play a pivotal role. These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of ...
Jiangtao SHAO, Junyu QI, Zexu HAN, Xueling GUO, Yike QI, Yingze WANG   +5 more
doaj   +1 more source