Results 41 to 50 of about 21,239 (181)

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model [PDF]

, 2019
Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which cause Charcot-Marie-Tooth disease type 2A (CMT2A), primarily affect the nervous system.
A.K.M.G. Muhammad, Antonietta Franco, Bergamin, Bin Lu, Burté, Cartoni, Cathleen M. Lutz, Chung, El Fissi, Gerald W. Dorn, Guyenet, Jesse Landeros, Lee, Michael Vazquez, Ritchie Ho, Robert H. Baloh, Rouzier, Santel, Santel, Shaomei Wang, Sharon Carmona, Shaughn Bell, Verhoeven, Yueqin Zhou   +23 more
core   +2 more sources

The Effect of 4 Weeks of Aerobic Training on Spatial Learning, Memory Performance and Mitochondrial Dynamics in the Hippocampal Tissue of Old Rats

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: Mitochondrial dysfunction is one of the main risk factors for neurological diseases which are associated with aging. On the other hand, aerobic exercise has beneficial effects on the brain health and cognitive function, and also ...
Ahmad Fazeli Sani, Hasan Matin homaee, Abdolali Banaeifar   +2 more
doaj  

Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events

Frontiers in Cell and Developmental Biology, 2022
Mitochondrial repair is essential to metabolic homeostasis. Outer mitochondrial membrane mitofusin (MFN) proteins orchestrate mitochondrial fusion that opposes mitochondrial degeneration caused by senescence.
Jiajia Li, Xiawei Dang, Antonietta Franco, Gerald W Dorn   +3 more
doaj   +1 more source

Disruption of fusion results in mitochondrial heterogeneity and dysfunction [PDF]

, 2005
Mitochondria undergo continual cycles of fusion and fission, and the balance of these opposing processes regulates mitochondrial morphology. Paradoxically, cells invest many resources to maintain tubular mitochondrial morphology, when reducing both ...
Chan, David C., Chen, Hsiuchen, Chomyn, Anne   +2 more
core   +2 more sources

Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer

Pharmacogenomics and Personalized Medicine, 2021
Xiaohua Liang,1 Shengqiang Dang2 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, 710038, People’s Republic of China; 2Department of Oncology, Chang’an Hospital of Xi’an, Xi&
Liang X, Dang S
doaj  

Mitofusin-2 acts as biomarker for predicting poor prognosis in hepatitis B virus related hepatocellular carcinoma

Infectious Agents and Cancer, 2018
Objective To investigate the expression of Mitofusin-2 (MFN2) in HCC tissues and its role in the development of HCC. Methods A total of 107 HCC specimens were collected for tissue microarray analysis and immunohistochemistry (IHC) analysis.
Xiumei Wang, Youde Liu, Jing Sun, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang, Weiwei Zhang   +7 more
doaj   +1 more source

Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p/IGF1R Signaling Axis

Frontiers in Genetics, 2021
Numerous studies have shown that the expression of circular RNA (circRNA) is closely related to the malignant progression of cancer. However, the role of circ-MFN2 in colorectal cancer (CRC) is unclear. Our study aims to explore the role and mechanism of
Defeng Liu, Shihao Peng, Yangyang Li, Tao Guo   +3 more
doaj   +1 more source

Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]

, 2019
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S., Coletti, D., de Castro, G. S., Festuccia, W. T., Lima, J. D. C. C., Ortiz-Silva, M., Otoch, J. P., Seelaender, M., Simoes, E., Tokeshi, F.   +9 more
core   +1 more source

RETRACTED: Mfn2 Overexpression Attenuates Cardio-Cerebrovascular Ischemia–Reperfusion Injury Through Mitochondrial Fusion and Activation of the AMPK/Sirt3 Signaling

Frontiers in Cell and Developmental Biology, 2020
Mitochondria are potential targets for the treatment of cardio-cerebrovascular ischemia–reperfusion (I/R) injury. However, the role of the mitofusin 2 (Mfn2) protein in regulating mitochondrial fusion and cell survival has not been investigated.
Min Liu, Xiaoyang Li, Dezhi Huang
doaj   +1 more source

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. [PDF]

, 2012
BackgroundMitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot-Marie-Tooth disease and dominant optic atrophy.
Bers, Donald M, Chen, Le, Chiamvimonvat, Nipavan, Cortopassi, Gino, Davies, Vanessa, Knowlton, Anne A, Liu, Tingting, Lu, Xiyuan, Tomilov, Alexey A, Tran, Alice, Votruba, Marcela   +10 more
core   +2 more sources