Results 21 to 30 of about 15,193 (187)

Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy, 2019
Background Several evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer’s disease (AD) preceding neuronal loss and the classical AD pathological hallmarks.
Dolores Siedlecki-Wullich, Judit Català-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez, Alfredo J. Miñano-Molina   +9 more
doaj   +4 more sources

Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis [PDF]

Journal of Translational Medicine
Background Bone marrow mesenchymal stem cells (BMSCs) are a crucial component of the tumor microenvironment (TME), with hypoxic conditions promoting their migration to tumors.
Meng Wang, Yi Zheng, Qian Hao, Guochao Mao, Zhijun Dai, Zhen Zhai, Shuai Lin, Baobao Liang, Huafeng Kang, Xiaobin Ma   +9 more
doaj   +2 more sources

Identification of miR-21-5p and miR-210-3p serum levels as biomarkers for patients with papillary renal cell carcinoma: a multicenter analysis. [PDF]

Transl Androl Urol, 2020
BACKGROUND: Expression of circulating serum microRNAs has not been studied in a cohort of patients with papillary renal cell carcinoma (pRCC) so far. We hypothesized that miRNA deregulation in malignant tissue is reflected in serum and could be used for ...
Kalogirou C, Ellinger J, Kristiansen G, Hatzichristodoulou G, Kübler H, Kneitz B, Busch J, Fendler A.   +7 more
europepmc   +3 more sources

Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia. [PDF]

Mol Med Rep, 2021
GATA binding protein 1 (GATA‑1) is one of the most important hematopoietic transcription factors in the production of blood cells, such as platelets, eosinophils, mast cells and erythrocytes. GATA‑1 regulates the participation of microRNA (miRNAs/miRs) in erythroid differentiation under normoxia. However, GATA‑1 expression and the regulation of miR‑210‑
Hu C, Yan Y, Fu C, Ding J, Li T, Wang S, Fang L.   +6 more
europepmc   +4 more sources

miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3. [PDF]

Onco Targets Ther, 2021
Lung cancer represents one of the most frequent solid tumors. Adenocarcinoma is a common type of tumor and a significant threat to individual health globally. MicroRNAs (miRNAs) are recognized as critical governors of gene expression during carcinogenesis, while their effects on lung cancer occurrence and development are required for further ...
Chen Q, Zhang H, Zhang J, Shen L, Yang J, Wang Y, Ma J, Zhuan B.   +7 more
europepmc   +5 more sources

Overexpression of miR-210-3p Impairs Extravillous Trophoblast Functions Associated with Uterine Spiral Artery Remodeling. [PDF]

Int J Mol Sci, 2021
Hsa-miR-210-3p has been reported to be upregulated in preeclampsia (PE); however, the functions of miR-210-3p in placental development are not fully understood, and, consequently, miR-210-3p’s role in the pathogenesis of PE is still under investigation. In this study, we found that overexpression of miR-210-3p reduced trophoblast migration and invasion,
Hayder H, Fu G, Nadeem L, O'Brien JA, Lye SJ, Peng C.   +5 more
europepmc   +4 more sources

MiR-210-3p-EphrinA3-PI3K/AKT axis regulates the progression of oral cancer. [PDF]

J Cell Mol Med, 2020
AbstractThis study aimed to explore new therapeutic targets to improve the survival rate of patients with oral squamous cell carcinoma (OSCC).MiR‐210‐3p, EphrinA3 and EMT related indices were evaluated in OSCC tissues and cell lines. In addition, the relationship between differential EphrinA3 expression and tumour progression was explored through ...
Wang L, Song Y, Wang H, Liu K, Shao Z, Shang Z.   +5 more
europepmc   +4 more sources

Differential expression of miR-23a-3p/-210-3p and /-18b-5p in sudden sensorineural hearing loss patients: A North American cohort study [PDF]

Scientific Reports
Sudden sensorineural hearing loss (SSNHL) is an acquired idiopathic hearing loss in which recent studies have suggested that microRNAs (miRNAs) have a pathogenetic role. We assessed six specific miRNAs linked to SSNHL in serum samples drawn from 11 SSNHL
Reyhaneh Abgoon, Ru Guo, Cole Needham, Desmond A. Nunez   +3 more
doaj   +2 more sources

Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo [PDF]

Cell Communication and Signaling
Background Neuropilin-1 (NRP1) is a transmembrane protein involved in surface receptor complexes for a variety of extracellular signals. NRP1 expression in human cancers is associated with prominent angiogenesis and advanced progression stage.
Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone   +12 more
doaj   +2 more sources

Extracellular Vesicles from NMN Preconditioned Mesenchymal Stem Cells Ameliorated Myocardial Infarction via miR-210-3p Promoted Angiogenesis. [PDF]

Stem Cell Rev Rep, 2023
Abstract Mesenchymal stem cell-derived extracellular vesicles (MSCs-EVs) possess cardioprotection in acute myocardial infarction. Nevertheless, the therapeutic intervention potential and the molecular mechanism of EVs from NMN (Nicotinamide mononucleotide) preconditioned hUCMSCs (N-EVs) in acute myocardial infarction remains unknown.
Pu Y, Li C, Qi X, Xu R, Dong L, Jiang Y, Gong Q, Wang D, Cheng R, Zhang C, Chen Y.   +10 more
europepmc   +3 more sources