Results 1 to 10 of about 467,497 (357)
miRNAs: Whys and Wherefores of miRNA-Mediated Regulation [PDF]
Current Biology, 2005 MiRNAs are assumed to be important in animal development and physiology, but their specific roles in vivo are still poorly understood. New bioinformatic and genetic studies are setting the stage for unraveling the specific biological functions of miRNAs.
Eric C. Lai
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Cancers, 2021 Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant.
Swalih P. Ahmed +2 more
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Integrative Analysis of miRNA-mRNA and miRNA-miRNA Interactions [PDF]
BioMed Research International, 2014 MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They are involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA and miRNA-miRNA interactions and their regulatory patterns using high-throughput miRNA and mRNA datasets. Aberrantly expressed miRNA
Hui Zhang +4 more
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Scientific Reports, 2023 In mammals, the suprachiasmatic nucleus of the hypothalamus is the master circadian pacemaker that synchronizes the clocks in the central nervous system and periphery, thus orchestrating rhythms throughout the body.
Lidia Giantomasi +6 more
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Glial Bmal1 role in mammalian retina daily changes
Scientific Reports, 2022 Visual information processing in the retina requires the rhythmic expression of clock genes. The intrinsic retinal circadian clock is independent of the master clock located in the hypothalamic suprachiasmatic nucleus and emerges from retinal cells ...
Serena Riccitelli +8 more
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The Tumor Cytosol miRNAs, Fluid miRNAs, and Exosome miRNAs in Lung Cancer [PDF]
Frontiers in Oncology, 2015 The focus of this review is to provide an update on the progress of microRNAs (miRNAs) as potential biomarkers for lung cancer. miRNAs are single-stranded, small non-coding RNAs that regulate gene expression and show tissue-specific signatures. Accumulating evidence indicates that miRNA expression patterns represent the in vivo status in physiology and
Xin eQin +4 more
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First manifestation and evolution of early left ventricular dysfunction in children with Duchenne muscular dystrophy [PDF]
The Moldovan Medical Journal, 2021 Background: Standard pediatric cardiology examinations and echocardiography fail to discover when the cardiomyopathy will occur in patient with Duchenne muscular dystrophy (DMD). Noninvasive markers are needed to fill this gap.
Iulia Rodoman +3 more
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Animal Health Production and Hygiene, 2021 The number of uncoded (non-coding; nc) RNAs with unknown functions is increasing. Since their first detections especially miRNA of ncRNAs have become very important. In fact, their importance has been well understood and their relations with diseases are more evident. It is clear that they can be used in the diagnosis of most diseases in the future.
SUVARIKLI ALAN, Beyza +2 more
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Deciphering miRNAs’ Action through miRNA Editing [PDF]
International Journal of Molecular Sciences, 2019 MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) translation or by promoting mRNA degradation. The outcome of a myriad of physiological processes and pathologies, including cancer, cardiovascular and metabolic diseases, relies ...
Marta Correia de Sousa +4 more
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Biology of Polyomavirus miRNA [PDF]
Frontiers in Microbiology, 2021 Polyomaviruses are a family of non-enveloped DNA viruses with wide host ranges. Human polyomaviruses typically cause asymptomatic infection and establish persistence but can be reactivated under certain conditions and cause severe diseases. Most well studied polyomaviruses encode a viral miRNA that regulates viral replication and pathogenesis by ...
Michael J. Imperiale, Wei Zou
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