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Mitochondrial Dynamics in Mitochondrial Diseases
Diseases, 2016 Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals. Mitochondrial dynamics, including mitochondrial fission/fusion, movements and turnover, are essential for the mitochondrial ...
Juan M. Suárez-Rivero +9 more
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Mitochondrial dynamics and mitochondrial quality control
Redox Biology, 2015 Mitochondria are cellular energy powerhouses that play important roles in maintaining cell survival, cell death and cellular metabolic homeostasis. Timely removal of damaged mitochondria via autophagy (mitophagy) is thus critical for cellular homeostasis
Hong-Min Ni +2 more
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Mitochondrial dynamics and apoptosis [PDF]
Genes & Development, 2008 In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control.
Der-Fen, Suen +2 more
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Mitochondrial dynamics during spermatogenesis [PDF]
Journal of Cell Science, 2020 ABSTRACT Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that safeguard normal cellular function. This relationship is especially strong in tissues with constitutively high energy demands, such as brain, heart and skeletal muscle.
Grigor Varuzhanyan, David C. Chan
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Mitochondrial dynamics in neurodegeneration [PDF]
Trends in Cell Biology, 2013 It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it became clear that these dynamic ...
Itoh, Kie +3 more
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Sphingolipids and Mitochondrial Dynamic [PDF]
Cells, 2020 For decades, sphingolipids have been related to several biological functions such as immune system regulation, cell survival, and proliferation. Recently, it has been reported that sphingolipids could be biomarkers in cancer and in other human disorders such as metabolic diseases.
Lais Brigliadori Fugio +2 more
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Mitochondrial dynamics in astrocytes [PDF]
Biochemical Society Transactions, 2014 Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca2+) levels in response to synaptic activity. Astrocyte Ca2+ elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons.
Stephen, TL +2 more
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Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets
Frontiers in Neuroscience, 2022 Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as mitochondrial dynamics.
Tianyuan Zou +29 more
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Mitochondrial Dynamics during Development
Newborn, 2023 Mitochondria are dynamic membrane-bound organelles in eukaryotic cells. These are important for the generation of chemical energy needed to power various cellular functions and also support metabolic, energetic, and epigenetic regulation in various cells.
He, Ling +2 more
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Emerging functions of mammalian mitochondrial fusion and fission [PDF]
, 2005 Mitochondria provide a myriad of services to the cell, including energy production, calcium buffering and regulation of apoptosis. How these diverse functions are coordinated among the hundreds of mitochondria in a given cell is largely unknown, but is ...
Chan, David C., Chen, Hsiuchen
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