Results 11 to 20 of about 1,859,766 (381)

Mitochondrial dysfunction in cancer [PDF]

Menopause Review, 2014
Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes.
Kinga Księżakowska-Łakoma, Monika Żyła, Jacek R. Wilczyński   +2 more
doaj   +3 more sources

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance. [PDF]

EMBO J
Fellas A, Pidoux AL, Tong P, Hewes HH, Wallace EC, Allshire RC.   +5 more
europepmc   +3 more sources

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Theranostics, 2021
Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear ...
Meng Zhao, Yizhuo Wang, Lingzhi Li, Shuyun Liu, Chengshi Wang, Yujia Yuan, Guang Yang, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu   +10 more
semanticscholar   +1 more source

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2021
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are essential for the numerous biochemical processes underpinning cell viability.
Afzal Misrani, Sidra Tabassum, Li Yang
semanticscholar   +1 more source

Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer’s Disease

Antioxidants, 2020
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial ...
Md. Ataur Rahman, MD. Hasanur Rahman, Partha Biswas, Md. Shahadat Hossain, Rokibul Islam, Md. Abdul Hannan, Md Jamal Uddin, Hyewhon Rhim   +7 more
doaj   +1 more source

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

Frontiers in Genetics, 2022
Background: The molecular mechanisms underlying obstructive sleep apnea (OSA) and its comorbidities may involve mitochondrial dysfunction. However, very little is known about the relationships between mitochondrial dysfunction-related genes and OSA ...
Qian Liu, Qian Liu, Tao Hao, Lei Li, Daqi Huang, Ze Lin, Ze Lin, Yipeng Fang, Dong Wang, Xin Zhang, Xin Zhang, Xin Zhang   +11 more
doaj   +1 more source

The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications

Frontiers in Endocrinology, 2023
Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia, with absolute insulin deficiency or insulin resistance as the main cause, and causes damage to various target organs including the heart, kidney and neurovascular.
Ziwei Zhang, Qingxia Huang, Daqing Zhao, F. Lian, Xiangyan Li, Wen-wen Qi   +5 more
semanticscholar   +1 more source

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment

Frontiers in Microbiology, 2022
Mitochondria, which is essential for adequate innate immune response, energy metabolism and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host cell ...
Chao Shang, Zirui Liu, Yilong Zhu, Jing Lu, Chenchen Ge, Cuiling Zhang, Nan Li, N. Jin, Yiquan Li, Mingyao Tian, Xiao Li   +10 more
semanticscholar   +1 more source

Mitochondrial Dysfunction in Depression [PDF]

Current Neuropharmacology, 2016
Depression is the most debilitating neuropsychiatric disorder with significant impact on socio-occupational and well being of individual. The exact pathophysiology of depression is still enigmatic though various theories have been put forwarded. There are evidences showing that mitochondrial dysfunction in various brain regions is associated with ...
Bansal, Yashika, Kuhad, Anurag
openaire   +2 more sources

Mitochondria Targeted Antioxidant Significantly Alleviates Preeclampsia Caused by 11β-HSD2 Dysfunction via OPA1 and MtDNA Maintenance

Antioxidants, 2022
We have previously demonstrated that placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) dysfunction contributes to PE pathogenesis. We sought to elucidate molecular mechanisms underlying 11β-HSD2 dysfunction-induced PE and to seek potential ...
Jing Long, Yan Huang, Zhengshan Tang, Yali Shan, Dou Feng, Wenqin Wang, Juan Liu, Ying Huang, Hang Gu, Dewei Guo, Ruojin Yao, Xin Ni   +11 more
doaj   +1 more source