Results 11 to 20 of about 532,827 (284)
Mitochondrial dysfunction in cancer [PDF]
Menopause Review, 2014 Mitochondria are semi-autonomous organelles of eukaryotic cells. They perform crucial functions such as generating most of the cellular energy through the oxidative phosphorylation (OXPHOS) system and some other metabolic processes.
Kinga Księżakowska-Łakoma +2 more
doaj +3 more sources
Mitochondrial Dysfunction in Depression [PDF]
Current Neuropharmacology, 2016 Depression is the most debilitating neuropsychiatric disorder with significant impact on socio-occupational and well being of individual. The exact pathophysiology of depression is still enigmatic though various theories have been put forwarded. There are evidences showing that mitochondrial dysfunction in various brain regions is associated with ...
Bansal, Yashika, Kuhad, Anurag
openaire +2 more sources
Mitochondrial Dysfunction in Atherosclerosis [PDF]
Circulation Research, 2007 Increased production of reactive oxygen species in mitochondria, accumulation of mitochondrial DNA damage, and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress.
Nageswara R, Madamanchi +1 more
openaire +2 more sources
International Journal of Oral Science, 2021 Porphyromonas gingivalis (P. gingivalis), a key pathogen in periodontitis, has been shown to accelerate the progression of atherosclerosis (AS). However, the definite mechanisms remain elusive.
Tong Xu +6 more
doaj +1 more source
How do yeast sense mitochondrial dysfunction?
Microbial Cell, 2016 Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that
Dmitry A. Knorre +3 more
doaj +1 more source
Mitochondrial dysfunction in cell senescence and aging
The Journal of Clinical Investigation, 2022 Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a decreased respiratory capacity per mitochondrion together with a decreased mitochondrial membrane ...
Satomi Miwa +3 more
doaj +1 more source
Advanced Science, 2023 Mitochondrial dysfunction has been recognized as the key pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD). The dysregulation of mitochondrial calcium ion (Ca2+) homeostasis and the mitochondrial permeability transition ...
Qian Zhang +10 more
doaj +1 more source
In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH:ubiquinone oxidoreductase Ndufc2 subunit [PDF]
, 2017 Ndufc2, a subunit of the NADH:ubiquinone oxidoreductase, plays a key role in the assembly and activity of complex I within the mitochondrial OXPHOS chain. Its deficiency has been shown to be involved in diabetes, cancer and stroke.
1000 Genomes Project Consortium +38 more
core +1 more source
Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]
, 2008 The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie +8 more
core +1 more source
Frontiers in Pharmacology, 2023 Metabolic syndrome (MS) is a complex group of metabolic disorders syndrome with hypertension, hyperuricemia and disorders of glucose or lipid metabolism. As an important organ involved in metabolism, the kidney is inevitably attacked by various metabolic
Peng Liu +5 more
doaj +1 more source