Results 21 to 30 of about 1,859,766 (381)
Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease
International Journal of Molecular Sciences, 2022 Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the world’s population. NAFLD includes a spectrum of progressive liver disease from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and ...
Raghu Ramanathan, A. Ali, J. Ibdah
semanticscholar +1 more source
Mitochondrial Dysfunction in Atherosclerosis [PDF]
Circulation Research, 2007 Increased production of reactive oxygen species in mitochondria, accumulation of mitochondrial DNA damage, and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress.
Nageswara R, Madamanchi +1 more
openaire +2 more sources
Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature
Current Environmental Health Reports, 2022 Mitochondria play various roles that are important for cell function and survival; therefore, significant mitochondrial dysfunction may have chronic consequences that extend beyond the cell.
Aalekhya Reddam +2 more
semanticscholar +1 more source
The crosstalk between HIFs and mitochondrial dysfunctions in cancer development
Cell Death and Disease, 2021 Mitochondria are essential cellular organelles that are involved in regulating cellular energy, metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic disease that is closely associated with mitochondrial dysfunction ...
Xingting Bao +7 more
doaj +1 more source
Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease
Journal of Neuroinflammation, 2022 Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key contributor to the onset and progression of AD, however, the mechanisms that ...
Yun Li +3 more
semanticscholar +1 more source
Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
Cells, 2022 The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species.
Hsin-Jung Ho, H. Shirakawa
semanticscholar +1 more source
How do yeast sense mitochondrial dysfunction?
Microbial Cell, 2016 Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that
Dmitry A. Knorre +3 more
doaj +1 more source
Advanced Science, 2023 Mitochondrial dysfunction has been recognized as the key pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD). The dysregulation of mitochondrial calcium ion (Ca2+) homeostasis and the mitochondrial permeability transition ...
Qian Zhang +10 more
doaj +1 more source
Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases
International Journal of Molecular Sciences, 2022 High mortality rates due to cardiovascular diseases (CVDs) have attracted worldwide attention. It has been reported that mitochondrial dysfunction is one of the most important mechanisms affecting the pathogenesis of CVDs.
Yu Liu +7 more
semanticscholar +1 more source
In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH:ubiquinone oxidoreductase Ndufc2 subunit [PDF]
, 2017 Ndufc2, a subunit of the NADH:ubiquinone oxidoreductase, plays a key role in the assembly and activity of complex I within the mitochondrial OXPHOS chain. Its deficiency has been shown to be involved in diabetes, cancer and stroke.
1000 Genomes Project Consortium +38 more
core +1 more source