Results 21 to 30 of about 532,827 (284)

Mitochondrial Dysfunction in Autism [PDF]

JAMA, 2010
Impaired mitochondrial function may influence processes highly dependent on energy, such as neurodevelopment, and contribute to autism. No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism.To evaluate mitochondrial defects in children with autism ...
Giulivi, Cecilia, Zhang, Yi-Fan, Omanska-Klusek, Alicja, Ross-Inta, Catherine, Wong, Sarah, Hertz-Picciotto, Irva, Tassone, Flora, Pessah, Isaac N   +7 more
openaire   +4 more sources

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Frontiers in Neuroscience, 2018
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD.
Ying Cheng, Feng Bai
doaj   +1 more source

Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines

Scientific Reports, 2022
Mitochondrial dysfunction promotes cancer aggressiveness, metastasis, and resistance to therapy. Similar traits are associated with epithelial mesenchymal transition (EMT).
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Viktoria Pider, Ira-Ida Skvortsova, Dragana Savic, Herbert Riechelmann   +6 more
doaj   +1 more source

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

, 2013
BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A, Amy K Reeve, Brierley EJ, Broadwater L, Campbell GR, Campbell GR, Campbell GR, Campbell GR, Don J Mahad, Doug M Turnbull, Dutta R, Dutta R, Graham R Campbell, Harding AE, Horvath R, Iryna Ziabreva, Johnson MA, Krishnan KJ, Kumleh HH, Larsson NG, Mahler A, McFarland R, Murphy JL, Nociti V, Palace J, Parise G, Patte M, Rahman S, Rahman S, Reeve AK, Richard Reynolds, Sakiyama Y, Taylor RW, Verny C, Witte ME, Witte ME, Yu-Wai-Man P   +36 more
core   +2 more sources

A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy. [PDF]

, 2014
We present the case of a 19-year-old female with a history of Down syndrome (DS) who was referred to our neuro-ophthalmology clinic for evaluation of Leber's hereditary optic neuropathy (LHON).
Frousiakis, Starleen E, Karanjia, Rustum, Pouw, Andrew E, Sadun, Alfredo A   +3 more
core   +3 more sources

Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease

Advanced Science, 2023
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD.
Qing Zheng, Hanghang Liu, Hao Zhang, Yaobao Han, Jiaxin Yuan, Tingting Wang, Yifan Gao, Zhen Li   +7 more
doaj   +1 more source

The multifaceted roles of natural products in mitochondrial dysfunction

Frontiers in Pharmacology, 2023
Mitochondria are the primary source of energy production in cells, supporting the metabolic demand of tissue. The dysfunctional mitochondria are implicated in various diseases ranging from neurodegeneration to cancer.
Qianrun Chen, Danhua Ruan, Jiayan Shi, Dongru Du, Ce Bian   +4 more
doaj   +1 more source

Anti-oxidants in Parkinson's disease therapy: a critical point of view [PDF]

, 2016
Parkinson's disease (PD) is a degenerative neurological syndrome, which is characterized by the preferential death of dopaminergic (DAergic) neurons in the SubstantiaNigra.
Beltramini, Mariano, Bisaglia, Marco, Bubacco, Luigi, Filograna, Roberta   +3 more
core   +2 more sources

Mitochondrial Dysfunction Meets Senescence [PDF]

Trends in Biochemical Sciences, 2016
Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence).
Suchira, Gallage, Jesús, Gil
openaire   +2 more sources

Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. [PDF]

, 2016
Mitochondria abnormalities in skeletal muscle may contribute to frailty and sarcopenia, commonly present in patients with chronic kidney disease (CKD).
Billings, Frederic T, Bojanowski, Matthew T, Brown, Nancy J, Gamboa, Jorge L, Gilliam, Laura A, Himmelfarb, Jonathan, Ikizler, T Alp, Roberts, L Jackson, Roshanravan, Baback, Yu, Chang   +9 more
core   +1 more source