Results 31 to 40 of about 1,859,766 (381)

Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy

Journal of Translational Medicine, 2023
Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic disease globally, and its associated complications including insulin resistance and diabetes have become threatening conditions for human health. Previous
Youwei Zheng, Shiting Wang, Jialiang Wu, Yong Wang   +3 more
semanticscholar   +1 more source

Mitochondrial Dysfunction in Parkinson’s Disease: From Mechanistic Insights to Therapy

Frontiers in Aging Neuroscience, 2022
Parkinson’s disease (PD) is one of the most common neurodegenerative movement disorders worldwide. There are currently no cures or preventative treatments for PD.
Xiaoying Gao, Tuo Yang, Ying-Li Gu, Xiao-Hong Sun   +3 more
semanticscholar   +1 more source

The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals

Biomolecules, 2022
Oxidative stress and mitochondrial dysfunction are associated with the pathogenesis of several human diseases. The excessive generation of reactive oxygen species (ROS) and/or lack of adequate antioxidant defenses causes DNA mutations in mitochondria ...
Muthuswamy Sathyabhama, Loganathan Chandramani Priya Dharshini, A. Karthikeyan, S. Kalaiselvi, Taesun Min   +4 more
semanticscholar   +1 more source

A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy. [PDF]

, 2014
We present the case of a 19-year-old female with a history of Down syndrome (DS) who was referred to our neuro-ophthalmology clinic for evaluation of Leber's hereditary optic neuropathy (LHON).
Frousiakis, Starleen E, Karanjia, Rustum, Pouw, Andrew E, Sadun, Alfredo A   +3 more
core   +3 more sources

Mitochondrial Dysfunction in Autism [PDF]

JAMA, 2010
Impaired mitochondrial function may influence processes highly dependent on energy, such as neurodevelopment, and contribute to autism. No studies have evaluated mitochondrial dysfunction and mitochondrial DNA (mtDNA) abnormalities in a well-defined population of children with autism.To evaluate mitochondrial defects in children with autism ...
Giulivi, Cecilia, Zhang, Yi-Fan, Omanska-Klusek, Alicja, Ross-Inta, Catherine, Wong, Sarah, Hertz-Picciotto, Irva, Tassone, Flora, Pessah, Isaac N   +7 more
openaire   +4 more sources

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Frontiers in Neuroscience, 2018
Increasing evidence suggests that abnormally hyperphosphorylated tau plays a vital role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction also has a recognized role in the pathophysiology of AD.
Ying Cheng, Feng Bai
doaj   +1 more source

Protective effect of natural products in the metabolic-associated kidney diseases via regulating mitochondrial dysfunction

Frontiers in Pharmacology, 2023
Metabolic syndrome (MS) is a complex group of metabolic disorders syndrome with hypertension, hyperuricemia and disorders of glucose or lipid metabolism. As an important organ involved in metabolism, the kidney is inevitably attacked by various metabolic
Peng Liu, Yao Chen, Jing Xiao, Wenhui Zhu, Xiaoming Yan, Ming Chen   +5 more
doaj   +1 more source

Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer’s Disease

International Journal of Molecular Sciences, 2021
Alzheimer’s disease (AD) is the most frequent cause of age-related neurodegeneration and cognitive impairment, and there are currently no broadly effective therapies.
Chanchal Sharma, Sehwan Kim, Youngpyo Nam, U. Jung, Sang Ryong Kim   +4 more
semanticscholar   +1 more source

Mitochondrial Dysfunction in Cardiovascular Diseases: Potential Targets for Treatment

Frontiers in Cell and Developmental Biology, 2022
Cardiovascular diseases (CVDs) are serious public health issues and are responsible for nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the development of most CVDs.
Jiaqi Yang, Qianyun Guo, Xunxun Feng, Yang Liu, Yujie Zhou   +4 more
semanticscholar   +1 more source

No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis [PDF]

, 2013
BACKGROUND: Mitochondrial dysfunction is an established feature of multiple sclerosis (MS). We recently described high levels of mitochondrial DNA (mtDNA) deletions within respiratory enzyme-deficient (lacking mitochondrial respiratory chain complex IV ...
Abadi A, Amy K Reeve, Brierley EJ, Broadwater L, Campbell GR, Campbell GR, Campbell GR, Campbell GR, Don J Mahad, Doug M Turnbull, Dutta R, Dutta R, Graham R Campbell, Harding AE, Horvath R, Iryna Ziabreva, Johnson MA, Krishnan KJ, Kumleh HH, Larsson NG, Mahler A, McFarland R, Murphy JL, Nociti V, Palace J, Parise G, Patte M, Rahman S, Rahman S, Reeve AK, Richard Reynolds, Sakiyama Y, Taylor RW, Verny C, Witte ME, Witte ME, Yu-Wai-Man P   +36 more
core   +2 more sources